Results 181 to 190 of about 9,135,638 (241)

Thyroid Peroxidase as an Autoantigen in Hashimoto’s Disease: Structure, Function, and Antigenicity

Hormone and Metabolic Research, 2018
Human thyroid peroxidase (TPO), is an important enzyme responsible for the biosynthesis of thyroid hormones and is a major autoantigen in autoimmune thyroid diseases (AITDs) such as the destructive Hashimoto’s thyroiditis.
Daniel E. Williams, Sarah N. Le, M. Godlewska, D. Hoke, A. Buckle   +4 more
semanticscholar   +1 more source

HASHIMOTO'S DISEASE

The Lancet, 1965
R.T. Cooke, R.W. Luxton
  +18 more sources

TSHR Gene Polymorphisms in the Enhancer Regions Are Most Strongly Associated with the Development of Graves' Disease, Especially Intractable Disease, and of Hashimoto's Disease.

Thyroid, 2017
BACKGROUND Graves' disease (GD) and Hashimoto's disease (HD) are autoimmune thyroid disorders distinguished by the presence or absence of antithyrotropin receptor (TSHR) antibodies (TRAb).
Asami Fujii, N. Inoue, Mikio Watanabe, Chisa Kawakami, Y. Hidaka, Y. Hayashizaki, Y. Iwatani   +6 more
semanticscholar   +1 more source

THE GENETICS OF HASHIMOTO'S DISEASE

Endocrinology and Metabolism Clinics of North America, 2000
Despite strong epidemiologic evidence in favor of a genetic component in the etiology of HT, few hereditary risk factors have been consistently identified. These factors include the HLA and CTLA-4 genes. The mechanisms by which these genes confer increased susceptibility to HT are unclear.
Barbesino G, CHIOVATO, LUCA
openaire   +3 more sources

Hashimoto's Thyroiditis and the Collagen Diseases [PDF]

Postgraduate Medicine, 1964
Growing recognition of Hashimoto's thyroiditis is only partly due to increased awareness and improved diagnostic methods. Recent evidence suggests an increase in the actual incidence of the disease. It also seems probable that a number of connective tissue diseases are associated more often with Hashimoto's thyroiditis than would be expected on a ...
Kenneth L. Becker, Richard H. Ferguson
openaire   +2 more sources

Increases of the Th1/Th2 cell ratio in severe Hashimoto's disease and in the proportion of Th17 cells in intractable Graves' disease.

Thyroid, 2009
BACKGROUND T helper type 1 (Th1), Th2, and Th17 cells produce interferon (IFN)-gamma, interleukin (IL)-4, and IL-17A, respectively. We reported that IFN-gamma and IL-4 gene polymorphisms, which are related to higher IFN-gamma and lower IL-4 production ...
Takashi Nanba, Mikio Watanabe, N. Inoue, Y. Iwatani   +3 more
semanticscholar   +1 more source

Auto-immunity in Hashimoto's disease and its implications.

Journal of Clinical Endocrinology and Metabolism, 1957
RECENT workers (1, 2, 3) have described abnormalities in the serum proteins of patients with Hashimoto's disease, namely, high values for gamma globulins and for the results of flocculation tests.
D. Doniach, I. Roitt
semanticscholar   +1 more source

Hashimoto's Disease in Childhood

Archives of Pediatrics & Adolescent Medicine, 1955
Hashimoto's struma, or struma lymphomatosa, is considered to be a disease of the fifth and sixth decades, but it nevertheless can occur over a wide range of age. In their excellent review of the material from the Massachusetts General Hospital, Statland, Wasserman, and Vickery1reported 51 cases between the ages of 10 and 74 years. All were females. Two
H. Clinton Davis, E. A. Hanske
openaire   +3 more sources

Abnormal binding of thyroid hormone in sera from patients with Hashimoto's disease.

Journal of Clinical Endocrinology and Metabolism, 1967
Thyroid hormone binding was studied in the sera of 15 patients with Hashimoto's disease by conventional paper and gel electrophoretic techniques utilizing 125I-T4.
B. Premachandra, H. Blumenthal
semanticscholar   +1 more source

Probing the normal and autoimmune B cell repertoire with Epstein-Barr virus. Frequency of B cells producing monoreactive high affinity autoantibodies in patients with Hashimoto's disease and systemic lupus erythematosus.

Journal of Immunology, 1988
The frequency of cell precursors producing Ig of different classes and Ag-binding activities were determined, using EBV-infection and limiting dilution assays, in healthy subjects and patients with autoimmune disease.
M. Nakamura, S. Burastero, Y. Ueki, J. Larrick, A. Notkins, P. Casali   +5 more
semanticscholar   +1 more source