Results 71 to 80 of about 420,517 (259)

Integration of quantitative MRI and liver function indices to predict early tumor response after stereotactic body radiotherapy for hepatocellular carcinoma: A prospective study

Clinical and Translational Radiation Oncology
Background: Early response assessment following stereotactic body radiotherapy (SBRT) for hepatocellular carcinoma (HCC) is challenging. We prospectively investigated whether changes in diffusion-weighted magnetic resonance imaging (DWI)-derived apparent
Osamu Tanaka, Takao Kojima, Akihiro Ohbora, Takuya Taniguchi, Kousei Adachi, Shuto Nakaya, Masayuki Matsuo   +6 more
doaj   +1 more source

Assessing transporter‐mediated rifampin–linezolid interaction using physiologically‐based pharmacokinetic modelling

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims The study aims to develop a physiologically‐based pharmacokinetic (PBPK) model to quantitatively evaluate the role of ATP‐binding cassette sub‐family B member 1 (ABCB1) and ATP‐binding cassette super‐family G member 2 (ABCG2) in the drug–drug interaction (DDI) between rifampin and linezolid and to predict the impact of high‐dose rifampin ...
Hoang Dat Nguyen, Vinh Hoa Pham, Richard M. Hoglund, Joel Tarning, Junjie Ding   +4 more
wiley   +1 more source

Marked Tachycardia, complete right bundle branch block, and lactic acidosis following ingestion of Cannabidiol (CBD) gummies: A case report

Toxicology Reports
The increasing availability of cannabidiol (CBD) products worldwide has raised concerns about their safety profile; although CBD is generally considered safe, adverse effects have been reported, particularly from overdose.
Masatoshi Inoue, Miya Hiramatsu, Naoki Kamegai, Junichiro Yamamoto   +3 more
doaj   +1 more source

Risk of cardiac, neuropsychiatric and musculoskeletal adverse events with levothyroxine: Systematic review

British Journal of Clinical Pharmacology, EarlyView.
Abstract Levothyroxine (LT4) is the standard treatment for hypothyroidism and the most widely prescribed medication worldwide. Although generally safe, regulatory reports list potential cardiac, neuropsychiatric and musculoskeletal adverse events (AEs). Clarifying their clinical relevance is essential.
Bala Swetha Baskaran, Mohammad Ali Omrani, Flory T. Muanda   +2 more
wiley   +1 more source

The flexible, the stereotyped and the in‐between: putting together the combinatory tool use origins hypothesis

Biological Reviews, EarlyView.
ABSTRACT Tool use research has long made the distinction between tool using that is considered learned and flexible, and that which appears to be instinctive and stereotyped. However, animals with an inherited tool use specialisation can exhibit flexibility, while tool use that is spontaneously innovated can be limited in its expression and facilitated
Jennifer A. D. Colbourne, Alice M. I. Auersperg   +1 more
wiley   +1 more source

Grooved Surface of the Obturator Internus Muscle With Two Distinct Adjacent Parts

Clinical Anatomy, EarlyView.
ABSTRACT The specific anatomical features of the obturator internus, particularly those of its medial surface, remain insufficiently characterized. This study investigated the morphology of the obturator internus muscle by focusing on the shape of its medial surface and potential age‐related changes.
Satoru Muro, Junichi Tsuchiya, Takuya Ibara, Akimoto Nimura, Keiichi Akita   +4 more
wiley   +1 more source

The Lipid Parameters and Lipoprotein(a) Excess in Hashimoto Thyroiditis

International Journal of Endocrinology, 2015
Objective. The risk of atherosclerotic heart disease is increased in autoimmune thyroiditis, although the reason is not clear. Lipoprotein(a) (Lp(a)) excess has been identified as a powerful predictor of premature atherosclerotic vascular diseases.
D. O. Yetkin, B. Dogantekin
doaj   +1 more source

The Association of Subclinical Insulin Resistance with Thyroid Autoimmunity in Euthyroid Individuals

Acta Clinica Croatica, 2020
Hashimoto thyroiditis is characterized by anti-thyroid peroxidase (anti-TPO) and anti-thyroglobulin (anti-Tg) antibodies that gradually lead to thyroid cell destruction.
Kristina Blaslov, Domagoj Gajski, Vesna Vucelić, Petar Gaćina, Gorana Mirošević, Jelena Marinković, Milan Vrkljan, Krešimir Rotim   +7 more
doaj   +1 more source

Purification, Fluorescent Labeling, and Detyrosination of Mammalian Cell Tubulin for Biochemical Assays

Cytoskeleton, EarlyView.
ABSTRACT Microtubules play essential roles in numerous cellular processes. All microtubules are built from the protein tubulin, yet individual microtubules can differ spatially and temporally due to their tubulin isotype composition and post‐translational modifications (PTMs).
Ezekiel C. Thomas, Yang Yue, Morgan L. Pimm, Takashi Hotta, Ryoma Ohi, Kristen J. Verhey   +5 more
wiley   +1 more source

Development and validation of clinical prediction model for functional independence measure following stroke rehabilitation

Journal of Stroke and Cerebrovascular Diseases
Objectives: To develop and internally validate a clinical prediction model that includes balance ability and nutritional indices for the motor-functional independence measure (M-FIM) at 90 days post-stroke stroke.
Shinya Fukuda, PT, Norio Yamamoto, MD, PhD, Yosuke Tomita, PT, Takeshi Matsumoto, PT, Tomoya Shinohara, OT, Tatsuro Ohno, PT, Hitoshi Fukuda, MD, PhD, Tetsuya Ueba, PhD, MD   +7 more
doaj   +1 more source