The orphan cytochrome P450 CYP107J1 with unknown redox partners was rationally modified into H2O2‐driven form. The QE (E251Q/T252E) mutant produced valuable chemicals by simply mixing the enzyme with substrate and H2O2. ABSTRACT Cytochrome P450 monooxygenases (P450s) not only play many physiological roles in oxidative metabolism but are also promising ...
Hideki Kato +5 more
wiley +1 more source
Endoscopic antireflux mucoplasty using the reopenable-clip over-the-line method for refractory gastro-esophageal reflux disease. [PDF]
Hashimoto S +6 more
europepmc +1 more source
UNC45B Reduction With Aging: A Myofiber‐Intrinsic Promoting Factor for Sarcopenia
Aging reduces Unc45b expression in fast‐twitch muscle, concomitant with reduction in muscle contractile capacity and muscle mass in mice. Unc45b deficiency initially reduces depolarization‐induced force, followed by a decline in fast‐twitch muscle mass in adult mice.
Taiga Mishima +17 more
wiley +1 more source
Parity as a Risk Factor for Differentiated Thyroid Carcinoma: A Population-based Study.
Dan R +4 more
europepmc +1 more source
Successful Treatment of Overlapping Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease and Glial Fibrillary Acidic Protein Astrocytopathy With Plasma Exchange. [PDF]
Ashida C +7 more
europepmc +1 more source
A case of Hashimoto encephalopathy in a Malay woman with Graves disease
CS Ngiu +6 more
openalex +2 more sources
This meta‐analysis included 2292 patients with severe asthma who underwent biologic switching across 23 countries/regions. The most prevalent switching pattern was from mepolizumab to benralizumab, with suboptimal asthma control being the primary reason.
Yang Zheng +13 more
wiley +1 more source
Relationship between immune-related adverse events and treatment outcome of immune checkpoint inhibitors for advanced non-small cell lung cancer: a retrospective cohort study. [PDF]
Hashimoto T +17 more
europepmc +1 more source
Melkersson-Rosenthal syndrome in a patient with Hashimoto disease [PDF]
Leszek Frąckowiak +3 more
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