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Targeting the 3C Protease of Hepatitis A Virus Subgenotype IB: Virtual Screening and Identification of Potent Lead Candidates [PDF]
Hepatitis A virus (HAV) infection remains a global public health concern in both developing and developed countries. In the present study, we identified anti-HAV drugs, using AutoDock Vina Modeling software, and evaluated the compounds in vitro ...
Tatsuo Kanda +5 more
doaj +2 more sources
Hepatitis A diagnosis relies on serology and occasionally on hepatitis A virus (HAV) RNA detection. For timely diagnosis and the avoidance of drawing additional blood, molecular testing is often performed as reflex testing by using blood specimens that ...
Mario Poljak +2 more
exaly +3 more sources
Genetic variability of hepatitis A virus genotype I strains in Bulgaria, 2011–2023 [PDF]
Background The HAV transmission generally occurs through faecal-oral transmission, contaminated water or food, poor sanitary conditions or poor hygiene.
Elitsa Golkocheva-Markova +12 more
doaj +2 more sources
Artikeln bedriver en litteraturhistoriskt orienterad läsning av Josefine Klougarts Om mørke (2013). Artikeln argumenterar för att Klougarts roman stilistiskt och strukturellt är inspirerad av Virginia Woolfs författarskap, och att Klougart skriver in sig
Henrik Johnsson
doaj +3 more sources
The family Hepeviridae comprises the species Orthohepevirus A–D (HEV-A to -D). HEV-C genotype 1 (HEV-C1, rat HEV) is able to infect humans. This study investigated whether an optimized HEV-A cell culture system is able to propagate the cell culture ...
Mathias Schemmerer +2 more
doaj +1 more source
Enteric viral hepatitis in the Socialist Republic of Vietnam (Southern Vietnam)
Aim: To study the hepatitis A (HAV) and hepatitis Е (HEV) prevalence in the Southern region of Vietnam based on the frequency analysis of the antibodies to hepatitis A and E viruses detection in the local population and groups at increased risk of ...
Yu. V. Ostankova +8 more
doaj +1 more source
No Evidence for Orthohepevirus C in Archived Human Samples in Germany, 2000–2020
Orthohepevirus C1, also known as rat hepatitis E virus (HEV), has been shown to sporadically cause disease in immunocompromised and immunocompetent adults. While routine serological assays vary in reactivity, rat HEV is not detected in routine HEV RT-PCR.
Mirko Faber +4 more
doaj +1 more source
Pathogenicity and virulence of hepatitis A virus
Hepatitis A is an acute infection of the liver, which is mostly asymptomatic in children and increases the severity with age. Although in most patients the infection resolves completely, in a few of them it may follow a prolonged or relapsed course or ...
Rosa M Pintó +6 more
doaj +1 more source
Hepatitis a virus genotypes and strains from an endemic area of Europe, Bulgaria 2012–2014
Background Hepatitis A virus (HAV) infection is endemic in Eastern European and Balkan region countries. In 2012, Bulgaria showed the highest rate (67.13 cases per 100,000) in Europe.
Roberto Bruni +12 more
doaj +1 more source
Cell Culture Systems and Drug Targets for Hepatitis A Virus Infection
Hepatitis A virus (HAV) infection is one of the major causes of acute hepatitis, and this infection occasionally causes acute liver failure. HAV infection is associated with HAV-contaminated food and water as well as sexual transmission among men who ...
Tatsuo Kanda +5 more
doaj +1 more source

