Results 91 to 100 of about 111,994 (335)

Cell Cycle Control of Nuclear Metabolism Couples Phosphatidylinositol Signaling to Histone Methylation

open access: yesAdvanced Science, EarlyView.
Nuclear metabolism oscillates during cell cycle progression. Quantitative chromatome proteomics and imaging reveal phase‐specific dynamics of PIP5K1A and nuclear PIP2, linking phosphatidylinositol metabolism to histone methylation. This work identifies nuclear lipid metabolism as a previously unrecognized regulatory axis coordinating chromatin ...
Antoni Gañez‐Zapater   +13 more
wiley   +1 more source

Reentrant Hawking–Page phase transition of charged Gauss–Bonnet-AdS black holes in the grand canonical ensemble

open access: yesEuropean Physical Journal C: Particles and Fields
In this paper, we study the reentrant Hawking–Page transition in the grand canonical ensemble of Gauss–Bonnet AdS spacetime. We find that the four-dimensional Gauss–Bonnet hyperbolic AdS black hole always has a reentrant Hawking–Page transition in the ...
Xiao-yan Hu, Yuan-zhang Cui, Wei Xu
doaj   +1 more source

Charged Hawking radiation and the entropy variation in a Reissner–Nordström black hole

open access: yesPhysics Letters B, 2018
Under charged Hawking radiation, we calculate the entropy of the scalar field in the interior volume of a Reissner–Nordström (RN) black hole and investigate the proportional relation between this entropy and the Bekenstein–Hawking entropy. Comparing with
Xin-Yang Wang   +2 more
doaj   +1 more source

A Bifunctional T3SS‐Effector Simultaneously Cleaves Host MAP Kinase and Inhibits PPM1A Phosphatase

open access: yesAdvanced Science, EarlyView.
Pathogenic bacteria exploit the metalloprotease effector NleD to subvert host defenses. Structural, biochemical, and infection analyses reveal a bifunctional mechanism by which NleD binds and inhibits the host phosphatase PPM1A while preserving its proteolytic activity against MAPKs.
Yaakov Socol   +18 more
wiley   +1 more source

A Plug‐and‐Play Volume Minimizing Micromixer

open access: yesAdvanced Science, EarlyView.
ABSTRACT Microscale fluid mixing has numerous applications where rapid and efficient mixing is required, including drug discovery, bio‐analysis and point‐of‐care diagnostics. Conventional soft lithography processes, however, make the integration of robust and reliable mixing difficult to implement in practice, especially across different flow rates ...
Kirill Kolesnik   +3 more
wiley   +1 more source

Information-carrying Hawking radiation and the number of microstate for a black hole

open access: yesNuclear Physics B, 2016
We present a necessary and sufficient condition to falsify whether a Hawking radiation spectrum indicates unitary emission process or not from the perspective of information theory.
Qing-yu Cai, Chang-pu Sun, Li You
doaj   +1 more source

A 3D In Vitro Model of the Human Hepatobiliary Junction

open access: yesAdvanced Science, EarlyView.
A 3D human organoid platform reconstructs the hepatobiliary junction between primary adult hepatocytes and intrahepatic cholangiocytes. These adult hepatobiliary organoids (aHBOs) support directional bile transport from canaliculi to ductule‐like structures, enable quantitative imaging of junction dynamics, and reveal cell‐type‐specific vulnerabilities
Ashley D. Westerfield   +13 more
wiley   +1 more source

Hawking radiation, the Stefan–Boltzmann law, and unitarization

open access: yesPhysics Letters B, 2016
Where does Hawking radiation originate? A common picture is that it arises from excitations very near or at the horizon, and this viewpoint has supported the “firewall” argument and arguments for a key role for the UV-dependent entanglement entropy in ...
Steven B. Giddings
doaj   +1 more source

Restriction of Individual Branched‐Chain Amino Acids has Distinct Effects on the Development and Progression of Alzheimer's Disease in 3xTg Mice

open access: yesAdvanced Science, EarlyView.
Protein restriction (PR) slows Alzheimer's disease (AD) in mice, and other benefits of PR are due to decreased branched‐chain amino acids (BCAAs). We show that restricting any BCAA has benefits, with sex‐ and BCAA‐specific impacts on pathology, molecular signaling, and cognition.
Reji Babygirija   +22 more
wiley   +1 more source

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