Results 71 to 80 of about 678,841 (321)

Circulating tumor cells: advancing personalized therapy in small cell lung cancer patients

Molecular Oncology, EarlyView.
Small cell lung cancer (SCLC) is an aggressive form of lung cancer that spreads rapidly to secondary sites such as the brain and liver. Cancer cells circulating in the blood, “circulating tumor cells” (CTCs), have demonstrated prognostic value in SCLC, and evaluating biomarkers on CTCs could guide treatment decisions such as for PARP inhibitors ...
Prajwol Shrestha, Steven Kao, Veronica K. Cheung, Wendy A. Cooper, Nico van Zandwijk, John E. J. Rasko, Dannel Yeo   +6 more
wiley   +1 more source

A new probabilistic shift away from seismic hazard reality in Italy? [PDF]

, 2014
Objective testing is a key issue in the process of revision and improvement of seismic hazard assessments. Therefore we continue the rigorous comparative analysis of past and newly available hazard maps for the territory of Italy against the seismic activity observed in reality. The final Global Seismic Hazard Assessment Program (GSHAP) results and the
arxiv   +1 more source

Cell‐free and extracellular vesicle microRNAs with clinical utility for solid tumors

Molecular Oncology, EarlyView.
Cell‐free microRNAs (cfmiRs) are small‐RNA circulating molecules detectable in almost all body biofluids. Innovative technologies have improved the application of cfmiRs to oncology, with a focus on clinical needs for different solid tumors, but with emphasis on diagnosis, prognosis, cancer recurrence, as well as treatment monitoring.
Yoshinori Hayashi, Janelle‐Cheri Millen, Romela Irene Ramos, Jennifer A. Linehan, Timothy G. Wilson, Dave S. B. Hoon, Matias A. Bustos   +6 more
wiley   +1 more source

KRAS and GNAS mutations in cell‐free DNA and in circulating epithelial cells in patients with intraductal papillary mucinous neoplasms—an observational pilot study

Molecular Oncology, EarlyView.
This study demonstrates that KRAS and GNAS mutations are more prevalent in patients with resected intraductal papillary mucinous neoplasms (IPMN) compared to those under clinical surveillance. GNAS mutations significantly differ between the two patient cohorts, indicating that their absence may serve as a potential biomarker to support conservative ...
Christine Nitschke, Marie Tölle, Philipp Walter, Kira Meißner, Mara Goetz, Jolanthe Kropidlowski, Andreas W. Berger, Jakob R. Izbicki, Felix Nickel, Thilo Hackert, Klaus Pantel, Harriet Wikman, Faik G. Uzunoglu   +12 more
wiley   +1 more source

Flood risk management and ‘fairness’: aspirations and reality

E3S Web of Conferences, 2016
Flood risk management in United Kingdom has been going through a process of rapid change in the last decade or so, no doubt spurred on by a series of very serious floods since the year 2000.
Penning-Rowsell Edmund C., Priest Sally J., King Diana   +2 more
doaj   +1 more source

Emergence of Lava Dome from the Crater Lake of Kelud Volcano, East Java

Indonesian Journal on Geoscience, 2014
DOI: 10.17014/ijog.v4i4.83Kelud Volcano (+1731 m) in East Java is one of the most active and dangerous volcanoes in Indonesia. A large lake occupies the summit crater.
Sri Hidayati, Ahmad Basuki, Kristianto Kristianto, Iyan Mulyana   +3 more
doaj   +1 more source

On‐treatment dynamics of circulating extracellular vesicles in the first‐line setting of patients with advanced non‐small cell lung cancer: the LEXOVE prospective study

Molecular Oncology, EarlyView.
The LEXOVE prospective study evaluated plasma cell‐free extracellular vesicle (cfEV) dynamics using Bradford assay and dynamic light scattering in metastatic non‐small cell lung cancer patients undergoing first‐line treatments, correlating a ∆cfEV < 20% with improved median progression‐free survival in responders versus non‐responders.
Valerio Gristina, Viviana Bazan, Nadia Barraco, Simona Taverna, Mauro Manno, Samuele Raccosta, Anna Paola Carreca, Marco Bono, Tancredi Didier Bazan Russo, Francesco Pepe, Pasquale Pisapia, Lorena Incorvaia, Giuseppe Badalamenti, Giancarlo Troncone, Umberto Malapelle, Daniele Santini, Antonio Russo, Antonio Galvano   +17 more
wiley   +1 more source

Characteristics and evolution of geoheritages in Mentougou District in the Xishan area, Beijing

Shuiwen dizhi gongcheng dizhi
Mentougou District, the core region of Xishan in Beijing, is located at the junction of Yanshan and Taihang mountains, where mountainous areas account for 98.5%. Over the long geological history, it has remained rich geoheritages.
Jinrui HE, Shangzhi XU, Qingwei SONG, Chunyan HAO, Ying DONG, Shuhong RAN, Jiayue WU, Zhaolin YU, Yilong ZHENG, Miao SUN   +9 more
doaj   +1 more source

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source

Using mobile disaster response system in bridge management

Journal of Civil Engineering and Management, 2014
Over the years, various hydro-meteorological disasters have impacted many countries and civilians, thus decreasing the losses caused by these disasters has become important for disaster management.
Ming-Kuan Tsai, Nie-Jia Yau
doaj   +1 more source