Results 131 to 140 of about 24,424,015 (291)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Evaluating the Use of Multisite Probabilistic Seismic Hazard Analysis: A Case of Sarpol-e Zahab City, Iran. [PDF]
Pure Appl Geophys, 2022 Yaghmaei-Sabegh S, Mohammadi A.
europepmc +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Linear and Quadratic Functionals of RandomHazard rates: an Asymptotic Analysis [PDF]
A popular Bayesian nonparametric approach to survival analysis consists in modeling hazard rates as kernel mixtures driven by a completely random measure.
Giovanni Peccati, Igor Prünster
core
Task and hazard analysis of metro drivers and recommendations to improvement
Salāmat-i kār-i Īrān, 2017 Background and aims: Metro driving is one of the newest jobs in Iran. Therefore, there are few studies were conducted on the tasks and hazards of metro drivers.
Y Khossravi +2 more
doaj
Food safety, livestock health, and productivity of a farm fatting Japanese black cattle following implementation of a certificated Hazard Analysis and Critical Control Point (HACCP) system. [PDF]
J Vet Med Sci, 2023 Akaike H, Nagai M, Okatani AT, Morita Y.
europepmc +1 more source
Quantitative Hazard and Risk Analysis
Advances in Electrical and Electronic Engineering, 2006 In this paper a quantitative method for hazard and risk analysis is discussed. The method was developed and introduced for the allocation of safety requirements to the functions of a railway signaling remote control system.
Tarnai, G., Sághi, B., Krbilová, I.
openaire +2 more sources
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Equity, Options and Efficiency in the Presence of Moral Hazard [PDF]
This paper provides a general equilibrium analysis of an economy with production under uncertainty in which the firms' capital (ownership) structure creates a moral hazard problem for their managers.
Michael Magill
core