Results 61 to 70 of about 556,353 (246)
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Regional Hazard Analysis For Use In Vulnerability And Risk Assessment
Quaestiones Geographicae, 2015 A method for supporting an operational regional risk and vulnerability analysis for hydrological hazards is suggested and applied in the Island of Cyprus.
Maris Fotios +5 more
doaj +1 more source
Risk-Based Early Warning System for Pluvial Flash Floods: Approaches and Foundations
Geosciences, 2019 In times of increasing weather extremes and expanding vulnerable cities, a significant risk to civilian security is posed by heavy rainfall induced flash floods.
Julian Hofmann, Holger Schüttrumpf
doaj +1 more source
Software Hazard and Safety Analysis [PDF]
, 2002 Safety is a system property and software, of itself, cannot be safe or unsafe. However software has a major influence on safety in many modern systems, e.g. aircraft and engine controls, railway signalling, and medical equipment.The paper outlines the principles of system hazard and safety analysis, and briefly describes work on adapting classical ...
openaire +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Identifying AI Hazards and Responsibility Gaps
IEEE AccessWith the expansion of artificial intelligence (AI) in general, but especially in self-driving cars in the United States, there is an increasing need for new hazard analysis approaches to determine if and how AI contributes to accidents.
Mary L. Cummings
doaj +1 more source
Online Hazard Analysis for Autonomous Robots [PDF]
, 2011 This paper presents a novel approach for designing robotic systems. The methodology aims to build on traditional functional hazard analysis, with the addition of processes aimed to improve the safety of autonomous personal robots. This will be achieved with the use of a safety protection system, developed during the hazard analysis stage.
Roger Woodman +3 more
openaire +2 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source