Results 141 to 150 of about 298,774 (265)

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Innovative tools and methods for toxicity testing within PARC work package 5 on hazard assessment. [PDF]

Front Toxicol, 2023
De Castelbajac T, Aiello K, Arenas CG, Svingen T, Ramhøj L, Zalko D, Barouki R, Vanhaecke T, Rogiers V, Audebert M, Oelgeschlaeger M, Braeuning A, Blanc E, Tal T, Rüegg J, Fritsche E, Marx-Stoelting P, Rivière G.   +17 more
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Integrated Chemical and Hazard Assessment of Plastic Pellets from the <i>Toconao</i> Spill (Galicia, Spain) Indicates Potential for Environmental Harm. [PDF]

Environ Sci Technol
Morales-Caselles C, Booth AM, Baztan J, Berget LM, Carmona E, Corcoll N, Dirven H, Filella M, Gómez-Martínez D, Herzke D, Hjertholm H, Jahnke A, Jepsen PM, Kardgar AK, Lorenz C, Negi N, Rojo-Nieto E, Snapkow I, Sørensen L, Syberg K, Takada H, Turner A, Carney-Almroth B.   +22 more
europepmc   +1 more source

Editorial: Inorganic particles and fibres: integrating minero-chemistry and hazard assessment for eco-exposome development. [PDF]

Front Chem, 2023
Petriglieri JR, Pavan C, Holian A, Turci F.   +3 more
europepmc   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Radiological Hazard Assessment of Soil at North Oil Company Using Spatial Distribution and Monte Carlo Simulation in Kirkuk Governorate, Iraq. [PDF]

Sci Rep
Namq BF, Wais TY.
europepmc   +1 more source

Toxicity by descent: A comparative approach for chemical hazard assessment. [PDF]

Environ Adv, 2022
Colbourne JK, Shaw JR, Sostare E, Rivetti C, Derelle R, Barnett R, Campos B, LaLone C, Viant MR, Hodges G.   +9 more
europepmc   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Detection of Microbial Contamination in Nanomaterials Using LAL, rFC and Cell-Based Assays: Implications for Nanotoxicological Hazard Assessment. [PDF]

Nanomaterials (Basel)
Lei P, Zegeye FD, Alswady-Hoff M, Marcolungo C, Danielsen PH, Madsen AM, Wallin H, Vogel U, Zienolddiny-Narui S, Erdem JS.   +9 more
europepmc   +1 more source