Results 1 to 10 of about 496,309 (246)

Cranial irradiation disrupts homeostatic microglial dynamic behavior [PDF]

Journal of Neuroinflammation
Cranial irradiation causes cognitive deficits that are in part mediated by microglia, the resident immune cells of the brain. Microglia are highly reactive, exhibiting changes in shape and morphology depending on the function they are performing ...
Alexandra O. Strohm, Carl Johnston, Eric Hernady, Brian Marples, M. Kerry O’Banion, Ania K. Majewska   +5 more
doaj   +3 more sources

RETRACTED: PAK3 downregulation induces cognitive impairment following cranial irradiation

eLife, 2023
Cranial irradiation is used for prophylactic brain radiotherapy as well as the treatment of primary brain tumors. Despite its high efficiency, it often induces unexpected side effects, including cognitive dysfunction.
Haksoo Lee, Hyunkoo Kang, Changjong Moon, BuHyun Youn   +3 more
doaj   +3 more sources

Low dose cranial irradiation-induced cerebrovascular damage is reversible in mice. [PDF]

PLoS ONE, 2014
BACKGROUND: High-dose radiation-induced blood-brain barrier breakdown contributes to acute radiation toxicity syndrome and delayed brain injury, but there are few data on the effects of low dose cranial irradiation.
Nikolett Sándor, Fruzsina R Walter, Alexandra Bocsik, Petra Sántha, Boglárka Schilling-Tóth, Violetta Léner, Zoltán Varga, Zsuzsanna Kahán, Mária A Deli, Géza Sáfrány, Hargita Hegyesi   +10 more
doaj   +3 more sources

Dose‐dependent cranial irradiation associations with brain structures and neuropsychological outcomes in children with posterior fossa brain tumors [PDF]

Brain and Behavior
Background Posterior fossa irradiation with or without whole brain irradiation results in high doses of radiation to the thalamus, hippocampus, and putamen, structures critical to cognitive functioning.
Mary Baron Nelson, Sharon H. O'Neil, Scarlet J. Cho, Sofia Dhanani, Jeffrey Tanedo, Brandon J. Shin, Jack Rodman, Arthur Olch, Kenneth Wong, Marvin D. Nelson Jr, Jonathan Finlay, Natasha Lepore   +11 more
doaj   +2 more sources

Prophylactic cranial irradiation in patients with resected small‐cell lung cancer: A systematic review and meta‐analysis [PDF]

Thoracic Cancer
Prophylactic cranial irradiation (PCI) was recommended for limited‐stage small‐cell lung cancer (SCLC) patients with complete or partial response to primary chemoradiotherapy. But it is still controversial regarding its role in SCLC patients who have had
Haoning Peng, Jianqi Hao, Bo Dong, Minqi Chen, Zongyuan Li, Cong Chen, Lunxu Liu   +6 more
doaj   +2 more sources

Radiation-mediated induction of apoptotic cell death in rat hippocampus [PDF]

Nuclear Technology and Radiation Protection, 2013
Ionizing radiation is commonly used in the treatment of brain tumors but it can impair cognitive functions, such as learning and memory. Since cognitive dysfunctions are predominantly result of cell death by apoptosis in hippocampal cells, in this ...
Veličković Nataša A., Đorđević Ana D., Drakulić Dunja R., Šećerov Bojana Lj., Grković Ivana S., Milošević Maja S., Horvat Anica I.   +6 more
doaj   +1 more source

Profiling of gene expression in the brain associated with anxiety-related behaviors in the chronic phase following cranial irradiation

Scientific Reports, 2022
Although the brain is exposed to cranial irradiation in many clinical contexts, including malignant brain tumor therapy, such exposure can cause delayed neuropsychiatric disorders in the chronic phase.
Hae-June Lee, Joong-Sun Kim, Changjong Moon, Yeonghoon Son   +3 more
doaj   +1 more source

Active Fraction Combination From Liuwei Dihuang Decoction Improves Adult Hippocampal Neurogenesis and Neurogenic Microenvironment in Cranially Irradiated Mice

Frontiers in Pharmacology, 2021
Background: Cranial radiotherapy is clinically used in the treatment of brain tumours; however, the consequent cognitive and emotional dysfunctions seriously impair the life quality of patients.
Mingxiao Wei, Mingxiao Wei, Shufang Feng, Lin Zhang, Lin Zhang, Chen Wang, Shasha Chu, Tianyao Shi, Wenxia Zhou, Yongxiang Zhang, Yongxiang Zhang   +10 more
doaj   +1 more source

Current Management and Progress in Radiotherapy for Small Cell Lung Cancer

Frontiers in Oncology, 2020
Radiotherapy (RT) and chemotherapy continue to be widely utilized in small cell lung cancer (SCLC) management. In most limited stage (LS)-SCLC cases, the standard initial therapy remains concurrent chemoradiotherapy (CRT), typically with an etoposide and
Michael C. Tjong, David Y. Mak, Jeevin Shahi, George J. Li, Hanbo Chen, Alexander V. Louie   +5 more
doaj   +1 more source

SCLC extensive disease – treatment guidance by extent or/and biology of response?

Radiation Oncology, 2008
In extensive disease of small cell lung cancer a doubling of the one-year-survival rate was reported in August 2007 by prophylactic cranial irradiation applied to patients who experienced any response to initial chemotherapy.
Müller Arndt-Christian, Eckert Franziska   +1 more
doaj   +1 more source