Results 91 to 100 of about 59,801 (304)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Consensus on the directions for development in quantitative microbial risk assessment

Zhongguo shipin weisheng zazhi
In recent years， quantitative microbial risk assessment （QMRA） for food safety has developed rapidly both domestically and internationally. QMRA integrates multidisciplinary theoretical knowledge and technical methodologies to quantitatively assess the ...
DONG Qingli, DING Tian, FANG Ting, LI Changcheng, LIAO Xinyu, LIU Yangtai, SHI Chunlei, WANG Wen, WANG Jun, WANG Xiang, WANG Hongxun, WANG Yeru, WANG Yibaina, XIAO Xingning, XU Jin, ZHANG Zhaohuan, ZHAO Yong   +16 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Ground-motion characterization for the probabilistic seismic hazard assessment in Turkey

, 2018
This study describes the methodology implemented to establish the ground-motion logic-tree for national probabilistic seismic hazard map of Turkey for shallow active crustal regions.
AKKAR, DEDE SİNAN, Yakut, Ahmet, Kale, Ozkan, Ceken, Ulubey   +3 more
core   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Unobservable Persistant Productivity and Long Term Contracts [PDF]

, 2009
We study the problem of a firm that faces asymmetric information about the productivity of its potential workers. In our framework, a worker’s productivity is either assigned by nature at birth, or determined by an unobservable initial action of the ...
Hopenhayn, Hugo, Jarque, Arantxa
core  

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Unobservable Persistant Productivity and Long Term Contracts [PDF]

We study the problem of a firm that faces asymmetric information about the productivity of its potential workers. In our framework, a worker’s productivity is either assigned by nature at birth, or determined by an unobservable initial action of the ...
Arantxa Jarque, Hugo H. Hopenhayn
core  

Characterizations of some bivariate models using reciprocal coordinate subtangents

Statistica, 2014
In the present paper, we consider the bivariate version of reciprocal coordinate subtangent (RCST) and study its usefulness in characterizing some important bivariate models.
Sreenarayanapurath Madhavan Sunoj, Sreejith Thoppil Bhargavan, Jorge Navarro   +2 more
doaj   +1 more source