Results 121 to 130 of about 59,801 (304)

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Repeated moral hazard and recursive Lagrangeans

This paper shows how to solve dynamic agency models by extending recursive Lagrangean techniques à la Marcet and Marimon (2011) to problems with hidden actions. The method has many advantages with respect to promised utilities approach (Abreu, Pearce and
Mele, Antonio
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

An open-source simulation platform to support and foster research collaboration in natural hazards engineering

Frontiers in Built Environment
Computational simulation is a critical tool for assessing the impacts of natural hazards and informing risk mitigation and resilience strategies. The NHERI SimCenter has developed an open-source, modular framework that integrates performance-based ...
Adam Zsarnóczay, Gregory G. Deierlein, Frank McKenna, Matthew Schoettler, Sang-Ri Yi, Barbaros Cetiner, Aakash Bangalore Satish, Jinyan Zhao, Justin Bonus, Abiy F. Melaku, Sina Naeimi, Pedro Arduino, Rachel Davidson, Rachel Davidson, Catherine Gorle, Sanjay Govindjee, Ahsan Kareem, Tracy L. Kijewski-Correa, Tracy L. Kijewski-Correa, Laura N. Lowes, Michael Motley, Seymour M. J. Spence, Ertugrul Taciroglu, Alexandros A. Taflanidis, Matthew DeJong   +24 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Characterization of hazard function factorization by Fisher information in minima and upper record values

The hazard function is an important characteristic for the analysis of reliability data. It is therefore of interest to see under what conditions it can be expressed as the product of a function of the variable and a function of the parameter.
Hofmann, Glenn, Ahmadi, Jafar, Balakrishnan, N.   +2 more
core  

Modeling to COVID-19 and cancer data: Using the generalized Burr-Hatke model

Journal of Radiation Research and Applied Sciences
This paper describes an extended version of the Burr–Hatke distribution via generalizing its survival function. This model is called as the generalized Burr-Hatke distribution. The suggested model's hazard rate function can be non-increasing (decreasing)
Ibrahim E. Ragab, Sadaf Khan, Najwan Alsadat, Farrukh Jamal, Gholamhossein G. Hamedani, Mohammed Elgarhy   +5 more
doaj   +1 more source

Characterization and measurement of duration dependence in hazard rates models [PDF]

, 2002
in terms of a decreasing/increasing hazard function can solely be used as a basis for revealing whether negative/positive duration dependence is present or not. However, when concern is directed to comparison and measurement of the extent of duration dependence in hazard rate models alternative definitions and methods are called for.
openaire   +5 more sources

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Randomization with Asymmetric Information [PDF]

It is by now well-known that, in the presence of moral hazard or adverse selection, randomization of insurance premia and benefits may be Pareto efficient.
Richard J. Arnott, Joseph E. Stiglitz
core