Results 201 to 210 of about 2,593,582 (300)

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

The patient behind the tumour: Host-related factors as determinants of immunotherapy efficacy in advanced cSCC. [PDF]

J Eur Acad Dermatol Venereol
Ruiz ES, Silk AW.
europepmc   +1 more source

In vitro generation of regulatory T cells: A challenging tool for studying immune aging in humans

FEBS Open Bio, EarlyView.
In vitro induction of human regulatory T cells using standard protocols generates suppressive, Foxp3‐expressing CD4+ T cells independently of TGF‐β supplementation and donor age. Regulatory T (Treg) cells play a key role in immune tolerance and homeostasis.
Lynn Muller, Jana Bleher, Birgit Weinberger, Lourdes Rocamora‐Reverte   +3 more
wiley   +1 more source

New approach methodologies for next-generation risk assessment of nanomaterials and nano-enabled products. [PDF]

Nano Converg
Lee E, Chary A, Gerelkhuu Z, Weber P, Virmani I, Brugger BA, Ribeiro IRS, Brun E, Lacconi V, Bang H, Kwon IH, Pohl A, Yoon J, Kim SW, Papadiamantis AT, Chowdhury RR, Hwang DY, Lamon L, Ort MJ, Paparella M, Sosnina EA, Serra A, Morikka J, Campini L, Koch K, Afantitis A, Greco D, Lynch I, Sullivan K, Yoon S, Lee TG, Park JW, Martinez DST, Dadhania VP, Campagnolo L, Neuhaus W, Friedrichs S, Buerki-Thurnherr T, Yoon TH, Serchi T.   +39 more
europepmc   +1 more source

Determinants of undergraduate bioscience engagement: Validating attendance barriers and classroom spatial behaviour across institutions

FEBS Open Bio, EarlyView.
Student engagement extends beyond simple attendance. Across 891 bioscience students from three universities, attendance behaviour was associated mainly with structural influences, whereas classroom spatial behaviour reflected affective and sensory factors.
Nigel Page, Rachel J. Hunt, Lauren J. Albee, Daniel Berwick, Alison Snape   +4 more
wiley   +1 more source

Integrated risk prioritization of rubber additives based on hazard ranking and exposure characterization. [PDF]

Eco Environ Health
Wang S, Dai W, Wang B, Heng L.
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Gradient Is Not Enough: Stroke Volume Index as the True Arbiter of Risk in Advanced Aortic Stenosis. [PDF]

Struct Heart
Shah AH.
europepmc   +1 more source

A Low Psoas Muscle Index Was Associated With a Poorer Overall Survival in Patients Who Underwent Percutaneous Nephrostomy

Aging and Cancer, EarlyView.
In patients with malignant ureteral obstruction undergoing percutaneous nephrostomy, sarcopenia defined by a low psoas muscle index was independently associated with poor overall survival on multivariate Cox regression analysis, suggesting that preoperative assessment of psoas muscle index may aid prognostic stratification in this population.
Kota Shimokihara, Takashi Kawahara, Kazuhide Makiyama, Hiroji Uemura   +3 more
wiley   +1 more source

Strengthening awareness and preparedness of human dermatophilosis surveillance in the Region of the Americas. [PDF]

Rev Panam Salud Publica
Pan American Health Organization.
europepmc   +1 more source