Results 161 to 170 of about 328,314 (314)
Topp-Leone Exponentiated Pareto Distribution: Properties and Application to Covid-19 Data
Journal of Statistical Theory and Applications (JSTA)This paper proposes a new Topp-Leone Exponentiated Pareto (TLEtP) distribution. The new distribution family is derived by expanding the Topp Leone-G family of distributions with additional positive shape parameters.
Fabio M. Correa +3 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
A Flexible Class of Purchase Incidence Models
Purchase incidence models estimated on household scanner panel data typically assume the household's decision interval to be one week. However, it is well known in the econometrics literature that discrete-time models are highly sensitive to the assumed ...
Trichy Krishnan, Seethu Seetharaman
core
Employment Fluctuations with Downward Wage Rigidity: The Role of Moral Hazard [PDF]
This paper studies the cyclical dynamics of Mortensen and Pissarides' (1994) model of job creation and destruction when workers' effort is not perfectly observable, as in Shapiro and Stiglitz (1984).
Jansen, Marcel, Costain, James
core
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Generalized Linear Models for Flexible Parametric Modeling of the Hazard Function. [PDF]
Med Decis Making, 2019 Kearns B +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Estimation in change-point hazard function models
In this paper, we consider hazard function models with a change-point allowing for random censoring when the base-line hazard function is unknown with some parameters.
Zhao, L. C., Wu, Y. H., Wu, C. Q.
core
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source