Results 91 to 100 of about 486,614 (292)

HAZARD RATE ESTIMATION OF TEMPORAL POINT PROCESS, CASE STUDY: HAZARD RATE ESTIMATION NUSATENGGARA REGION [PDF]

, 2013
Estimasi Hazard rate adalah salah satu topic penting dalam prakiraan kemunculan gempa. Prakiraan kemunculan gempa adalah bagian dari statistic seismologi dimana subjek utamanya adalah point process.
A, Islamiyati, A J, Kresna, Raupong, N, Sunusi, A.J, , Kresna, Sunusi N, Islamiyati A, Kresna A J   +7 more
core  

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Models of Firm Dynamics and the Hazard Rate of Exits:Reconciling Theory and Evidence using Hazard Regression Models [PDF]

, 2005
This paper considers empirical work relating to models of firm dynamics. We show that a hazard regression model for firm exits, with a modification to accommodate age-varying covariate effects, provides an empirical framework accommodating many of the ...
Bhattacharjee, Arnab, Bhattacharjee, Arnab; id_orcid   +1 more
core  

Reliability Analysis of Improved Type-II Adaptive Progressively Inverse XLindley Censored Data

Axioms
This study offers a newly improved Type-II adaptive progressive censoring with data sampled from an inverse XLindley (IXL) distribution for more efficient and adaptive reliability assessments.
Refah Alotaibi, Mazen Nassar, Ahmed Elshahhat   +2 more
doaj   +1 more source

Joint weak hazard rate order under non-symmetric copulas

Dependence Modeling, 2016
A weak version of the joint hazard rate order, useful to stochastically compare not independent random variables, has been recently defined and studied in [4]. In the present paper, further results on this order are proved and discussed.
Pellerey Franco, Spizzichino Fabio
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Smooth backfitting for additive hazard rates [PDF]

Scandinavian Journal of Statistics
Abstract Smooth backfitting was first introduced in an additive regression setting via a direct projection alternative to the classic backfitting method by Buja, Hastie, and Tibshirani. This paper translates the original smooth backfitting concept to a survival model considering an additively structured hazard.
Stephan M. Bischofberger, Munir Hiabu, Enno Mammen, Jens Perch Nielsen   +3 more
openaire   +2 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source