Results 101 to 110 of about 486,614 (292)
The Wiener Process with a Random Non-Monotone Hazard Rate-Based Drift
MathematicsSeveral variations of stochastic processes have been studied in the literature to obtain reliability estimations of products and systems from degradation data.
Luis Alberto Rodríguez-Picón +3 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
MathematicsThe quality performance of many vital systems depends on how long the units are performing; hence, research works started focusing on increasing the reliability of systems while taking into consideration that many factors may cause the failures of ...
Hanan Haj Ahmad +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Claims Reporting and Risk Bearing Moral Hazard in Workers' Compensation : The Canadian Context [PDF]
This paper explores the Canadian context of workers' compensation (WC) by replicating, with Canadian data, a study carried out by Butler and Worrall (1991).
Guylaine Baril, Paul Lanoie
core
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Corporate insurance design with multiple risks and moral hazard [PDF]
, 2008 The paper provides novel insights on the effect of a firm’s risk management objective on the optimal design of risk transfer instruments. I analyze the interrelation between the structure of the optimal insurance contract and the firm’s objective to ...
Laux, Christian
core
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
The cost for the default of a loan : Linking theory and practice [PDF]
When calculating the cost of entering into a credit transaction the predominant stochastic component is the expected loss. Often in the credit business the one-year probability of default of the liable counterpart is the only reliable parameter.
Weißbach, Rafael, Sibbertsen, Philipp
core
The estimation of the hazard function of earthquakes in aceh province with likelihood approach
DesimalIn this article, we propose a novel application of the single decrement method with a likelihood approach to estimate the hazard function of earthquake events in Aceh province.
Ikhsan Maulidi +4 more
doaj +1 more source