Results 131 to 140 of about 486,614 (292)
Journal of Inequalities and ApplicationsThis paper develops a rigorous and unified preservation framework for hazard rate and relative average hazard rate stochastic orders in series and parallel systems with dependent component lifetimes. While preservation of hazard-rate-based orders is well
Thamer Manshi +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
A Simple Test for the Absence of Covariate Dependence in Hazard Regression Models
This paper extends commonly used tests for equality of hazard rates in a two-sample or k-sample setup to a situation where the covariate under study is continuous.
Bhattacharjee, Arnab
core
Achieving Constant Hazard Rate in Psychophysics Experiments
In psychophysics, it is sometimes desirable for the temporal onset of an event to be unpredictable, e.g. to control possible effects of expectation and temporal attention in behavioral or neural data.
Brian Maniscalco, Megan A. K. Peters
core +1 more source
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
The impact of volcanic eruption rate on pyroclastic hazard
Communications Earth & EnvironmentPyroclastic density currents – fast flows of hot gases, ash, and debris – are some of the most hazardous phenomena associated with explosive volcanic eruptions.
Domenico M. Doronzo
doaj +1 more source
Examining the Timing of Women's Retirement in Urban China: A Discrete Time Hazard Rate Approach. [PDF]
Contemp Econ Policy, 2018 Hare D.
europepmc +1 more source