Results 151 to 160 of about 486,614 (292)
Multimodal hazard rate for relapse in breast cancer: quality of data and calibration of computer simulation. [PDF]
Cancers (Basel), 2014 Retsky M, Demicheli R.
europepmc +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Hubungan Dividen Inisiasi dan Informasi Asimetri: Pendekatan Hazard Rate
Jurnal Siasat Bisnis, 2009 This research examines the dynamics of dividend policy applying the hazard model. The study focuses on the dividend initiation for a sample of firms went public on the Jakarta Stock Exchange between 1990 and 1997.
Hadri Kusuma
doaj
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Bias reduction in nonparametric hazard rate estimation
, 2003 The need of improvement of the bias rate of convergence of traditional nonparametric hazard rate estimators has been widely discussed in the literature. Initiated by recent developments in kernel density estimation we distinguish and extend three popular
Bagkavos, Dimitrios Ioannis
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Sickness and injury leave in France: moral hazard or strain? [PDF]
From 1997 to 2001, the total payment to compensate for sickness and injury leaves increased dramatically in France. Since this change coincided with a decrease in unemployment rate,three hypothesizes should be proposed as possible explanations ...
Thomas Renaud, Michel Grignon
core
Risk-dependent conditional survival analysis and annual hazard rate of primary ocular adnexal lymphoma. [PDF]
Discov OncolSong J, Chen S, Hu J.
europepmc +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Technology Transfer with Moral Hazard [PDF]
This paper develops an incomplete contract model of the licensing relationship that is susceptible to the moral hazard problem. The optimal contractual form of licensing derived in the model generates predictions that seem to be consistent with actual ...
Choi, Jay Pil
core