Results 121 to 130 of about 251,112 (311)
Study of Hazard Rate Functions on the Cumulative Damage Phenomenon
Journal of Mechanics, 2011 ABSTRACTIn this paper different failure mechanisms which yield cumulative damage are investigated through two types of hazard rate functions. They have been studied during the past two decades. Type A was developed early by assuming the hazard rate as a function of reliability. There are two kinds of trend, one follows the negative logistic decay model,
openaire +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Application of a simple nonparametric conditional quantile function estimator in unemployment duration analysis [PDF]
We consider an extension of conventional univariate Kaplan-Meier type estimators for the hazard rate and the survivor function to multivariate censored data with a censored random regressor.
Wilke, Ralf A., Wichert, Laura
core
A flexible parametric survival model which allows a bathtub-shaped hazard rate function
A new parametric (three-parameter) survival distribution, the lognormal--power function distribution, with flexible behaviour is introduced. Its hazard rate function can be either unimodal, monotonically decreasing or can exhibit a bathtub shape. Special
William J. Reed
core +1 more source
AppliedMathA novel statistical model, the Bounded Gamma–Gompertz Distribution (BGGD), is presented alongside a full characterization of its properties. Our investigation identifies maximum-likelihood estimation (MLE) as the most effective fitting procedure, proving
Tassaddaq Hussain +2 more
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Employment Fluctuations with Downward Wage Rigidity: The Role of Moral Hazard [PDF]
This paper studies the cyclical dynamics of Mortensen and Pissarides' (1994) model of job creation and destruction when workers' effort is not perfectly observable, as in Shapiro and Stiglitz (1984).
Jansen, Marcel, Costain, James
core
Nonparametric Estimation of Hazard Rate under the Constraint of Monotonicity
, 2000 . We show how to smoothly `monotonise' standard kernel estimators of hazard rate, using bootstrap weights. Our method takes a variety of forms, depending on choice of kernel estimator and on the distance function used to define a certain constrained
Gifford, JA +8 more
core +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source