Results 81 to 90 of about 251,112 (311)

Aging: damage accumulation versus increasing mortality rate [PDF]

If aging is understood as some process of damage accumulation, it does not necessarily lead to increasing mortality rates. Within the framework of a suggested generalization of the Strehler-Mildwan (1960) model, we show that even for models with ...
Maxim S. Finkelstein
core  

Parametric hazard rate models for long-term sickness absence [PDF]

, 2008
PURPOSE: In research on the time to onset of sickness absence and the duration of sickness absence episodes, Cox proportional hazard models are in common use. However, parametric models are to be preferred when time in itself is considered as independent
Roelen, Corne A. M., Koopmans, Petra C., Petra C. Koopmans, Corné A. M. Roelen, Koopmans, P.C., Groothoff, J.W., Johan W. Groothoff, Petra C. Koopmans, Roelen, C.A., Groothoff, Johan W.   +9 more
core   +1 more source

Characteristics of Hazard Rate Functions of Log-Normal Distributions

Journal of Physics: Conference Series, 2019
Abstract Distribution of Survival Analysis categorized in three functions those are: survival function, probability density function, and hazard rate function. Hazard rate function is used to analyze extreme value from a probability model of a distribution. One of the interesting distributions is log-normal distribution which is used for
D Kurniasari, R Widyarini, null Warsono, Y Antonio   +3 more
openaire   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Mathematical Properties of the Inverted Topp–Leone Family of Distributions

Mathematics
This article defines an inverted Topp–Leone distribution. Several mathematical properties and maximum likelihood estimation of parameters of this distribution are considered.
Daya K. Nagar, Edwin Zarrazola, Santiago Echeverri-Valencia   +2 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Asymptotics for sieve estimators of hazard rates: estimating hazard functionals [PDF]

, 2015
This paper derives asymptotics for functionals of a hazard model with an exposure-time effect and time-varying covariates. A semi-nonparametric sieve maximum likelihood estimator of a competing risks model based on the Cox proportional hazard is considered. Consistency of the estimator and its rate of convergence in the Fisher norm are derived.
openaire   +1 more source

On Bernstein polynomial estimators of the hazard rate function

Gulf Journal of Mathematics
For the density and distribution functions supported on the unit interval, Bernstein polynomial estimators are known to have good asymptotic properties under appropriate regularity conditions on the function to be estimated. In particular, these estimators are asymptotically unbiased over the entire unit interval.
Tayeb Djebbouri, Kouider Djerfi, Brahim Refafa   +2 more
openaire   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source