Results 91 to 100 of about 15,506,173 (331)
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Existence and monotonicity of solutions to moral hazard problems. [PDF]
This paper provides a method to prove existence of solutions to some moral hazard problems with infinite set of outcomes. The argument is based on the concept of nondecreasing rearrangement and on a supermodular version of Hardy–Littlewood’s inequality ...
Carlier, Guillaume, Dana, Rose-Anne
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Stochastic Orderings between Two Finite Mixtures with Inverted-Kumaraswamy Distributed Components
MathematicsIn this paper, we consider two finite mixture models (FMMs) with inverted-Kumaraswamy distributed components’ lifetimes. Several stochastic ordering results between the FMMs are obtained.
Raju Bhakta +3 more
doaj +1 more source
Statistica, 2019 In this article, we proposed and studied the inverted exponentiated gamma distribution (IEGD). IEGD is obtained by considering the inverse transformation of exponentiated gamma variate.
Abhimanyu Singh Yadav
doaj +1 more source
Likelihood Based Inference for Cause Specific Hazard Rates under Order Restrictions
Journal of Multivariate Analysis, 1995 We consider the competing risks model with grouped data or with discrete failure times where a unit is exposed to several risks, but its eventual failure is due to exactly one of the causes. We assume a discrete-time framework and allow for independent random censoring on the right.
Dykstra, R., Kochar, S., Robertson, T.
openaire +2 more sources
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Hubungan Dividen Inisiasi dan Informasi Asimetri: Pendekatan Hazard Rate
Jurnal Siasat Bisnis, 2009 This research examines the dynamics of dividend policy applying the hazard model. The study focuses on the dividend initiation for a sample of firms went public on the Jakarta Stock Exchange between 1990 and 1997.
Hadri Kusuma
doaj +4 more sources
FEBS Open Bio, EarlyView.Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo +4 more
wiley +1 more source
A rule-of-thumb for the variable bandwidth selection in kernel hazard rate estimation [PDF]
In nonparametric curve estimation the decision about the type of smoothing parameter is critical for the practical performance. The nearest neighbor bandwidth as introduced by Gefeller and Dette 1992 for censored data in survival analysis is specified by
Weißbach, Rafael, Gefeller, Olaf
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