Results 61 to 70 of about 15,506,173 (331)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Order Properties Concerning Tsallis Residual Entropy
MathematicsWith the help of Tsallis residual entropy, we introduce Tsallis quantile entropy order between two random variables. We give necessary and sufficient conditions, study closure and reversed closure properties under parallel and series operations and show ...
Răzvan-Cornel Sfetcu, Vasile Preda
doaj +1 more source
CORRECTION TO “DEPENDENCE, DISPERSIVENESS, AND MULTIVARIATE HAZARD RATE ORDERING”
Probability in the Engineering and Informational Sciences, 2006 In the article published last year, three inequalities should be in the opposite direction.
Khaledi, Baha-Eldin, Kochar, Subhash C.
openaire +3 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Stochastic Comparisons Between the Component and System Redundancy for Series Assembly Systems
پژوهشهای ریاضی, 2021 In this paper, we discuss stochastic comparisons of active redundancy at component level versus system level. We also consider series systems in order to compare their lifetimes using the usual stochastic, the hazard rate and the reversed hazard rate ...
Ebrahim Amini-Seresht, Ghobad Barmalzan
doaj
Applied Sciences, 2023 Effectively avoiding coal mine safety accidents has always been an important issue in the process of coal mining. In order to predict mine pressure hazard and reduce the occurrence of mine safety accidents, this paper innovatively combines logistic ...
Bobin Zhu +3 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
A Simple Test for the Absence of Covariate Dependence in Hazard Regression Models [PDF]
, 2004 This paper extends commonly used tests for equality of hazard rates in a two-sample or k-sample setup to a situation where the covariate under study is continuous.
Bhattacharjee, Arnab +3 more
core
Smoothed bootstrap bandwidth selection for nonparametric hazard rate estimation
Journal of Statistical Computation and Simulation, 2018 A smoothed bootstrap method is presented for the purpose of bandwidth selection in nonparametric hazard rate estimation for iid data. In this context, two new bootstrap bandwidth selectors are established based on the exact expression of the bootstrap ...
Inés Barbeito, R. Cao
semanticscholar +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source