Results 131 to 140 of about 7,485,935 (361)

Limitations of hazard ratios in clinical trials

European Heart Journal, 2018
Abstract
Mats J, Stensrud, John M, Aalen, Odd O, Aalen, Morten, Valberg   +3 more
openaire   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Recurrence Rate and Associated Factors of Primary Fallopian Tube Carcinoma in the South of Vietnam

Gynecology and Minimally Invasive Therapy
Objectives: This study aimed to determine the recurrence rate and related risk factors of primary fallopian tube cancer (PFTC). Materials and Methods: We conducted a retrospective study of 47 patients with histopathological diagnosis of PFTC treated at ...
Tuan Vo, Duy Nguyen, Thang Ho, Hoang Tran, Dat Nguyen, Thuong Bui, Thinh Cao, Brian Vo   +7 more
doaj   +1 more source

Stochastic Ordering of Exponential Family Distributions and Their Mixtures

, 2009
We investigate stochastic comparisons between exponential family distributions and their mixtures with respect to the usual stochastic order, the hazard rate order, the reversed hazard rate order, and the likelihood ratio order.
Hardy, Khaledi, Marshall, Shaked, Shaked, Yaming Yu, Yu   +6 more
core   +1 more source

Safety of the Deferral of Coronary Revascularization on the Basis of Instantaneous Wave-Free Ratio and Fractional Flow Reserve Measurements in Stable Coronary Artery Disease and Acute Coronary Syndromes. [PDF]

, 2018
OBJECTIVES: The aim of this study was to investigate the clinical outcomes of patients deferred from coronary revascularization on the basis of instantaneous wave-free ratio (iFR) or fractional flow reserve (FFR) measurements in stable angina pectoris ...
Al-Lamee, R, Alegria-Barrero, E, Alghamdi, A, Altman, J, Ambrosia, A, Baptista, SB, Bertilsson, M, et al., Cook, CM, Dehbi, HM, Escaned, J, Mejía-Rentería, H, Ryan, N   +11 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Association between metabolic syndrome severity score and cardiovascular disease: results from a longitudinal cohort study on Chinese adults

Frontiers in Endocrinology
ObjectiveThis study aimed to quantify the severity of metabolic syndrome(MetS) and investigate its association with cardiovascular disease(CVD) risk on Chinese adults.Methods13,500 participants from the Zhejiang Adult Chronic Disease Study were followed ...
Jing-jing Lin, Pin-yuan Dai, Jie Zhang, Yun-qi Guan, Wei-wei Gong, Min Yu, Le Fang, Ru-ying Hu, Qing-fang He, Na Li, Li-xin Wang, Ming-bin Liang, Jie-ming Zhong   +12 more
doaj   +1 more source

Factors Affecting Nutritional Attitudes among University Adults [PDF]

Pakistan Journal of Commerce and Social Sciences, 2017
The problem of malnutrition has never been good and the information regarding nutrition would be advantageous particularly in case of Pakistan because significant progress of nutrition awareness at regional level is scarce.
Jamal Abdul Nasir
doaj  

YPmodelPhreg: The Short-Term and Long-Term Hazard Ratio Model with Proportional Adjustment [PDF]

, 2023
Daewoo Pak, Song Yang
openalex   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source