Real‐World Comparison of High‐Efficacy Versus Non‐High‐Efficacy Therapies in Multiple Sclerosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective The choice of the first disease modifying treatment (DMT) in multiple sclerosis (MS) is a topic of great interest, and whether high‐efficacy DMTs should be the first choice remains debated. We compared treatment outcomes (no evidence of disease activity [NEDA] and its components) between treatment‐naïve relapsing–remitting MS (RRMS ...
Sarmad Al‐Araji +9 more
wiley +1 more source
A Comparison of Additional Benefit Assessment Methods for Time-to-Event Endpoints Using Hazard Ratio Point Estimates or Confidence Interval Limits by Means of a Simulation Study. [PDF]
Med Decis MakingBüsch CA +3 more
europepmc +1 more source
Marginal hazard ratio estimates in joint frailty models for heart failure trials. [PDF]
Biom J, 2019 Toenges G, Jahn-Eimermacher A.
europepmc +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To evaluate the long‐term impact of early intensive treatment (EIT) versus escalation (ESC) strategies using high‐efficacy disease‐modifying therapies (HE‐DMTs) on disability progression in relapsing multiple sclerosis (RMS). Methods This observational study included 4878 RMS patients from the Italian Multiple Sclerosis Register ...
Pietro Iaffaldano +47 more
wiley +1 more source
Instrumental variable approach for estimating a causal hazard ratio: application to the effect of postmastectomy radiotherapy on breast cancer patients. [PDF]
Obs Stud, 2019 Yang F, Cheng J, Huo D.
europepmc +1 more source
Time Ratios Or Hazard Ratios: Accelerating Toward A New Approach? [PDF]
Value in Health, 2015 C Parker +4 more
openaire +2 more sources
Association of the ICH Score With Withdrawal of Life‐Sustaining Treatment Over a 10‐Year Period
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective The intracerebral hemorrhage (ICH) score was developed to enhance provider communication and facilitate early severity assessment. We examined the association of the ICH score with mortality and withdrawal of life‐sustaining treatment (WLST) in a large, multicenter stroke registry, and evaluated temporal trends in these associations.
Nina Massad +15 more
wiley +1 more source
Causal inference of hazard ratio based on propensity score matching
, 2019 Shuhan Tang +5 more
openalex +2 more sources
Multimodal Autonomic Biomarkers Predict Phenoconversion in Pure Autonomic Failure
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Pure autonomic failure (PAF) presents with autonomic failure without other neurological features. A third develop central neurological features, fulfilling criteria for multiple system atrophy (MSA) and Lewy body diseases (LBD), including Parkinson's disease and Dementia with Lewy bodies.
S. Koay +12 more
wiley +1 more source