Results 151 to 160 of about 193,848 (310)

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Potential predictors affecting outcomes in a randomized controlled trial of support programs for parents of young adults with hazardous substance use. [PDF]

Addict Sci Clin Pract
Siljeholm O, Hammarberg A.
europepmc   +1 more source

FACILITIES WITH THE PRESENCE OF HAZARDOUS SUBSTANCES AND RADIATION IN BULGARIA - CHARACTERISTICS, SECURITY MEASURES DURING THEIR OPERATION AND STORAGE

T. Chavdarov, K. Gerginova, Mario Angelov, Christo Petkov   +3 more
openalex   +1 more source

Localisation of a source of hazardous substance dispersion using binary measurements [PDF]

, 2016
Branko Ristić, Ajith Gunatilaka, Ralph Gailis   +2 more
openalex   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Evaluation of a multi-component prevention concept for hazardous substance use among refugees in shared accommodations: study protocol for a cluster randomized controlled trial. [PDF]

Trials
Lorenz MH, Uricher J, Pauzar MI, Michalak J, Laging M, Heidenreich T.   +5 more
europepmc   +1 more source

FSUE “NAMI” work on reduction of complex urban air pollution with hazardous substances caused by vehicle operation

V. K. Azarov, M. A. Pervushin, В. Ф. Кутенев   +2 more
openalex   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

'Before, we ended up in conflicts, now we can provide support'-Experiences of Community Reinforcement and Family Training (CRAFT) for parents of young adults with hazardous substance use. [PDF]

BMC Psychiatry
Siljeholm O, Eckerström J, Molander O, Sundbye J, Hammarberg A.   +4 more
europepmc   +1 more source