Results 81 to 90 of about 224,569 (352)

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

Molecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon, Moa Stenudd, Margherita Zamboni, Kanar Alkass, Carl‐Johan Eriksson, Lars Pedersen, Alrik Schörling, Anna Thoss, Anders Bergh, Pernilla Wikström, Hans‐Olov Adami, Henrik Toft Sørensen, Henrik Druid, Jonas Frisén   +13 more
wiley   +1 more source

ATSDR public health investment : Massachusetts [PDF]

CDC/ATSDR support Massachusetts to reduce exposure to hazardous substances in the environment ATSDR funds 25 cooperative agreements to help states build their capacity to assess and respond to site-specific issues involving human exposure to hazardous ...

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Integrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes

Molecular Oncology, EarlyView.
In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková, Marie Ehrlichová, Alžběta Spálenková, Ivona Krus, Simona Šůsová, Viktor Hlaváč, Vlasta Němcová, Renata Koževnikovová, Markéta Trnková, David Vrána, Jiří Gatěk, Kateřina Kopečková, Marcela Mrhalová, Soňa Měšťáková, Pavel Souček   +14 more
wiley   +1 more source

Restriction of the use of hazardous substances (RoHS) in the personal computer segment: analysis of the strategic adoption by the manufacturers settled in Brazil

GEPROS: Gestão da Produção, Operações e Sistemas, 2015
The enactment of the RoHS Directive (Restriction of Hazardous Substances) in 2003, limiting the use of certain hazardous substances in electronic equipment has forced companies to adjust their products to comply with this legislation.
Ademir Brescansin, Mauro Silva Ruiz, Marcelo Luiz Dias da Silva Gabriel, Jefferson Lima da Silva   +3 more
doaj   +1 more source

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

Molecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim, Sungwoo Bae, Jaeyong Choi, Sun‐Wha Im, Bukyoung Cha, Gyeongseo Jung, Sun Wook Cho, Eul‐Ju Seo, Young Ah Lee, Jin Chul Paeng, Young Joo Park, Jong‐Il Kim   +11 more
wiley   +1 more source

ATSDR public health investment : Georgia [PDF]

CDC/ATSDR support Georgia to reduce exposure to hazardous substances in the environment ATSDR funds 25 cooperative agreements to help states build their capacity to assess and respond to site-specific issues involving human exposure to hazardous ...

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Tracking Chart 2005 Nike, Thailand 07027477D [PDF]

, 2005
This document is part of a digital collection provided by the Martin P. Catherwood Library, ILR School, Cornell University, pertaining to the effects of globalization on the workplace worldwide.
Fair Labor Association
core   +1 more source

ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee, Keyue Chen, Ryan Loke, Xiang Li, David Liubart, Golam T. Saffi, Jonathan T. S. Chow, Ché M. P. Melo, Lydia To, Leonardo Salmena   +9 more
wiley   +1 more source

ATSDR public health investment : Wisconsin [PDF]

CDC/ATSDR support helps Wisconsin reduce exposures to hazardous substances in the environment ATSDR funds 25 cooperative agreements to help states build their capacity to assess and respond to site-specific issues involving human exposure to hazardous ...

core  

THE WEEE MANAGEMENT AND ITS INFLUENCE ON ENVIRONMENT AND HUMAN HEALTH. CASE STUDY: MARAMUREȘ COUNTY, ROMANIA [PDF]

Carpathian Journal of Electrical Engineering, 2020
his paper addresses a number of issues regarding the management of waste electrical and electronic equipment (WEEE) and its influence on environmental and human health factors. The study was conducted for Maramures County to highlight the WEEE management
Irina SMICAL, Mariia ORFANOVA
doaj