Results 131 to 140 of about 652,688 (313)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Residence: health and fire hazards, 730 Magnolia Ave.
, 1959 Trash and discarded furniture creating fire and safety hazards in yard of ...
core +2 more sources
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Harney County Natural Hazards Mitigation Plan
, 2008 407 pp. Bookmarks supplied by UO. Published October 2007.The Harney County Multi-jurisdictional Natural Hazard Mitigation Plan is intended to assist Harney County, the Harney Electric Cooperative, and the cities of Burns and Hines in reducing its risk ...
Oregon Natural Hazards Workgroup +1 more
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Pakistan Journal of Medical ResearchBackground: A work-related danger is normally a circumstance that can possibly harm labourers. Occupational Safety and Health (OSH) was enacted to help all employers and their workers decrease job accidents, injuries, and medical illnesses. In Pakistan,
Anil Iqbal +4 more
doaj
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Lake County Multi-jurisdictional natural hazards mitigation plan
, 2007 429 pp. Maps, charts, tables, figures. Published November, 2007. Captured February 19, 2009.The plan goals describe the overall direction that Lake County agencies, organizations, and citizens can take toward mitigating risk from natural hazards.
Lake County (Or.) +1 more
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