Results 131 to 140 of about 766,490 (309)

Design and Evaluation of Noise Simulation Algorithm Using MATLAB Ray Tracing Engine for Noise Assessment and Prediction

Applied Sciences
The Malaysian Department of Occupational Safety and Health (DOSH) reported that noise-induced hearing loss (NIHL) accounted for 92% of occupational diseases in 2019. To address this, accurate risk assessment is crucial.
Precin Kalisalvan, Mohd Sayuti Ab Karim, Siti Nurmaya Musa   +2 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Regulator Theory, Natural Hazards, and Climate Change

Climate change is increasing variability in environmental conditions and the frequency and severity of natural hazards such as hurricanes, floods, and wildfires. In this paper, we use general systems theory to describe how disaster management systems are
Vic Wright, Kaine, Geoff, Wright, Vic, Geoff Kaine   +3 more
core   +1 more source

Climate Influences on Day and Overnight Use at California State Beaches and Coastal Parks

Land
State beaches and parks provide access to coastal environments for recreational activities that rely on access to the ocean, coastal climate, and scenic amenities. Approximately 46 million people visit state beaches in California annually, and another 20
Jeffrey S. Jenkins, Terence G. Young, Alexander M. Petersen, Felber J. Arroyave, Maria E. Medina-Chavarría   +4 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Assessment of Occupational Safety and Health among Sugar Industry Workers in Dera Ismail Khan: A Descriptive Study

Pakistan Journal of Medical Research
Background: A work-related danger is normally a circumstance that can possibly harm labourers. Occupational Safety and Health (OSH) was enacted to help all employers and their workers decrease job accidents, injuries, and medical illnesses. In Pakistan,
Anil Iqbal, Fazal Rehman, Abdul Ghaffar, Muhammad Shafiqe, Fawad Ahmed   +4 more
doaj  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Global warming level indicators of climate change and hotspots of exposure

Environmental Research: Climate
In the 21st century, a growing population will be exposed to various hazards caused by a warming climate. Here we present a new database of 12 climate change indicators with a total of 42 variants at different global warming levels (GWLs) (1.2 °C–3.5 °C),
Michaela Werning, Daniel Hooke, Volker Krey, Keywan Riahi, Bas van Ruijven, Edward A Byers   +5 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source