Results 11 to 20 of about 136,614 (358)

HBsAg Loss as a Treatment Endpoint for Chronic HBV Infection: HBV Cure

Viruses, 2022
Despite the availability of effective vaccines and antiviral therapy over the past two to three decades, chronic hepatitis B virus (HBV) infection remains a major global health threat as a leading cause of cirrhosis and liver cancer.
M. Moini, S. Fung
semanticscholar   +1 more source

Impact of HBsAg and HBcrAg levels on phenotype and function of HBV-specific T cells in patients with chronic hepatitis B virus infection

Gut, 2021
Objective Hepatitis B virus (HBV)-specific T cells are main effector cells in the control of HBV infection and hepatitis B surface antigen (HBsAg) is suggested to be a critical factor in the impaired immune response, a hallmark of chronic HBV infection ...
E. Aliabadi, Melanie Urbanek-Quaing, B. Maasoumy, B. Bremer, Martina Grasshoff, Yang Li, Christian Niehaus, H. Wedemeyer, A. Kraft, M. Cornberg   +9 more
semanticscholar   +1 more source

A Systematic Review and Model-Based Meta-Analysis of Pegylated-Interferon-α-Induced HBsAg Loss in Chronic Hepatitis B Virus Infection. [PDF]

CPT Pharmacometrics Syst Pharmacol
ABSTRACT Pegylated‐interferon‐α (Peg‐IFNα) is a treatment option for chronic hepatitis B virus (HBV) infection. To quantify treatment response variability, we conducted a model‐based meta‐analysis (MBMA) of hepatitis B surface antigen (HBsAg) loss, defined as a binary outcome based on HBsAg levels falling below the limit of detection, with Peg‐IFNα ...
Hanan NJ, Zierhut ML, Nader A, Mahajan A, Kaur A, Kumar K, Dixon SA, Das J, Magee M, Theodore D, Gielen V.   +10 more
europepmc   +2 more sources

Paradoxical HBsAg and anti-HBs coexistence among Chronic HBV Infections: Causes and Consequences

International Journal on Biological Sciences, 2021
Hepatitis B surface antigen (HBsAg) and Hepatitis B surface antibody (anti-HBs) were reported simultaneously among Hepatitis B virus (HBV) infections.
Xinyi Jiang, Le Chang, Ying Yan, Lunan Wang   +3 more
semanticscholar   +1 more source

Trends of Advanced Chronic Liver Disease Among 17,711 Persons in Mongolia During Years 2015-2023. [PDF]

J Viral Hepat
ABSTRACT Chronic liver diseases cause a significant burden in Asia. This study aims to characterise the pattern and factors associated with advanced chronic liver disease (aCLD) in a large cohort from Mongolia, which has the highest rate of liver cancer globally.
Kamal H, Jargalsaikhan G, Enkhtaivan S, Bruce D, Lindahl K, Dashtseren B, Ulziibadrakh T, Batkhuu M, Bat-Ulzii P, Byambabaatar S, Aleman S, Dashdorj NB.   +11 more
europepmc   +2 more sources

Mitochondrial stress in advanced fibrosis and cirrhosis associated with chronic hepatitis B, chronic hepatitis C, or nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Adaptive mitochondrial mechanisms allow mitochondrial resilience and prevent the worsening of fibrosis, while deregulation of these mechanisms promotes the progression from no/minimal‐mild (F0‐F2) fibrosis to advanced fibrosis and cirrhosis (F3‐F4). Abstract Background and Aims Hepatitis B virus (HBV) infection causes oxidative stress (OS) and alters ...
Dimitri Loureiro, Issam Tout, Stéphanie Narguet, Cheikh Mohamed Bed, Morgane Roinard, Ahmad Sleiman, Nathalie Boyer, Nathalie Pons‐Kerjean, Corinne Castelnau, Nathalie Giuly, Dorothy Tonui, Vassili Soumelis, Jamel El Benna, Patrick Soussan, Richard Moreau, Valérie Paradis, Abdellah Mansouri, Tarik Asselah   +17 more
wiley   +1 more source

Circulating serum HBsAg level is a biomarker for HBV-specific T and B cell responses in chronic hepatitis B patients

Scientific Reports, 2020
Chronic hepatitis B (CHB) infection functional cure is defined as sustained loss of HBsAg and several therapeutic strategies are in clinical development designed to pharmacologically reduce serum HBsAg, break immune tolerance, and increase functional ...
Jin Hyang Kim, Alip Ghosh, Natarajan Ayithan, S. Romani, A. Khanam, Jang-June Park, R. Rijnbrand, Lydia Tang, M. Sofia, S. Kottilil, Chris B. Moore, B. Poonia   +11 more
semanticscholar   +1 more source

IL-10 Promoter Polymorphism Distribution among HBsAg-Reactive and HBsAg-Nonreactive Blood Donors

Majalah Kedokteran Bandung, 2020
Hepatitis B surface antigen (HBsAg) serves as a serological marker for Hepatitis B virus (HBV) infection. People with HBV asymptomatic infection might readily donate blood due to the lack of clinical manifestations.
Rahmat Azhari Kemal, Arfianti Arfianti, Reni Oktora, Bebe Gani, Fauzia Andrini Djojosugito, Winarto Winarto   +5 more
doaj   +1 more source

Distribution of ABO, Rhesus Blood Groups, Transfusion Transmitted Diseases and Adverse Donor Reactions in a Blood Bank of a Tertiary Care Hospital: A Five Year Study [PDF]

National Journal of Laboratory Medicine, 2016
Introduction: Study of the distribution of A, B, O blood group systems is essential for genetic studies, medico – legal issues and importantly for efficient delivery of blood bank services. Also important is the immunologic safety of the donated blood
Lekha Mandodar, Archana Shetty, Vijaya Chowdappa   +2 more
doaj   +1 more source

MORPHOLOGICAL ANALYSIS OF HEPATITIS B VIRUS WITH ESCAPE MUTATIONS IN S-gene G145R AND S143L

Вопросы вирусологии, 2017
Background. In terms of serological properties and immunization, the wild type of HBsAg HBV and its G145R mutant behave as different antigens. This testifies to serious structural changes, which presumably could have a significant impact on the ...
M. V. Konopleva, M. V. Sokolova, N. V. Shevlyagina, A. I. Bazhenov, A. A. Fel’Dsherova, M. A. Krymskij, V. N. Borisova, T. A. Semenenko, V. G. Nesterenko, A. P. Suslov   +9 more
doaj   +1 more source