Results 41 to 50 of about 53,162 (283)

Characterisation of People Living With Chronic Hepatitis B Virus Infection in England and Stratification by HBsAg Levels: A Cross-Sectional Study. [PDF]

J Viral Hepat
ABSTRACT Characterisation of people with hepatitis B (PwHB) remains limited, particularly regarding treatment status, disease severity and biomarker profiles. Quantitative hepatitis B surface antigen (qHBsAg) is a key predictor of response to emerging therapies, but its distribution is poorly described.
Drysdale M, Gillespie IA, Christensen D, Davies J, Woods K, Roadknight G, Little S, Salih H, Várnai KA, Noble T, Cooke GS, Glampson B, Papadimitriou D, Mayer E, Khakoo SI, Davis C, Borca F, English L, Nastouli E, Matthews PC, Barnes E, Wang T.   +21 more
europepmc   +2 more sources

Effects of High‐ and Low‐Fat Meals on the Bioavailability and Pharmacokinetics of Votoplam, a HTT Gene Splicing Modifier

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Votoplam is a novel, orally bioavailable, small molecule HTT gene splicing modifier that is being developed for the treatment of Huntington's disease. This was a single dose, open‐label, two‐period, crossover food effect study that evaluated the effect of high‐ and low‐fat meals on 20 mg votoplam in healthy participants. There was a washout of
Lucy Lee, Amy‐Lee Richards, Nageswara Reddy, Brian Beers, Lee Golden, Ronald Kong   +5 more
wiley   +1 more source

Hepatitis B Virus Infection and Associated Factors Among Adults in Southwest Ethiopia: Community-Based Cross-Sectional Study

International Journal of General Medicine, 2020
Alemayehu Sayih Belay,1 Dejene Derseh Abateneh,1,2 Sisay Shewasinad Yehualashet,1,3 Kindie Mitiku Kebede1 1Mizan Tepi University, College of Health Sciences, Mizan Aman, Ethiopia; 2Kotebe Metropolitan University, Menelik II College of Medicine and Health
Belay AS, Abateneh DD, Yehualashet SS, Kebede KM   +3 more
doaj  

Recent advances in the treatment of chronic hepatitis B: where to start initial therapy?

Журнал инфектологии, 2014
This review summarizes recent advances in the study of the efficacy and safety of antiviral therapy in patients with chronic hepatitis B. Describe the modern concept of monitoring and treatment of these patients.
K. V. Zhdanov
doaj   +1 more source

Prevalence of Hepatitis B Virus among Pregnant Women Attending Antenatal Care in Alexandria

Journal of High Institute of Public Health, 2019
Background & Hepatitis B infection is a very serious public health problem. Perinatal vertical transmission is a common mode of transmission. Infants infected from their mothers will have a very high risk of developing chronic liver disease. Objective(s):
Marwa M. Fekry, Mona H. Hashish, Heba S. Selim, Abdel-Moneim Fawzy, Marwa M. Wahba   +4 more
doaj   +1 more source

Construction of bicistronic cassette for co-expressing hepatitis B surface antigen and mouse granulocyte-macrophage colony stimulating factor as adjuvant in tobacco plant

Pharmaceutical Biology, 2019
Context: The co-delivery of adjuvant and antigen has shown to be more effective for targeting the immune response than antigen alone. Therefore, designing an efficient bicistronic system is more assuring for production of both elements in the same ...
Sara Mohammadzadeh, Hamideh Ofoghi, Mina Ebrahimi-Rad, Parastoo Ehsani   +3 more
doaj   +1 more source

HBsAg clearance and seroconversion case in a patient with HBeAg-negative chronic hepatitis B on pegylated interferon α-2a therapy

Журнал инфектологии, 2014
Presented clinical case describes elimination followed by seroconversion HBsAg / HBsAb patient with HBeAg-negative chronic hepatitis B on antiviral therapy with pegylated interferon α2-a and achieving sustained virological response.
K. V. Zhdanov, D. A. Gusev, K. V. Kozlov, S. S. Zhabrov, A. V. Shekurov, A. V. Nagovitsyn, A. V. Mishin, E. V. Jakovleva   +7 more
doaj   +1 more source

Design, Synthesis, Physicochemical and Immunological Characterization of Dendrimer-HBsAg Conjugate

Vaccine Research, 2014
Manufacturing new Hepatitis B virus vaccines, specifically by the use of nanoparticles, is of high global interest. In this paper, a new biocompatible and biodegradable structure of nano-sized hepatitis B virus’ surface antigen (HBsAg) was generated by ...
Mohammad Sadeq Khosravy, Mehdi Shafiee Ardestani, Reza Ahangari Cohan, Delaram Doroud, Safieh Amini, Seyed Bahman Momen, Seyed Mohammad Atyabi, Hossien Heydari, Rohollah Vahabpour   +8 more
doaj  

Pre‐diagnostic immunological markers of bacterial translocation and liver cancer risk: A nested case–control analysis of 12 prospective cohorts

International Journal of Cancer, EarlyView.
What's New? Disruption of the gut–liver axis has been suggested to play an important role in liver carcinogenesis. However, limited prospective research has explored associations between potentially harmful gut‐derived bacterial products and liver cancer risk.
Cody Z. Watling, Peter T. Campbell, Barry I. Graubard, Yanyu Wang, Andrew T. Gewirtz, Xuehong Zhang, Matthew J. Barnett, Julie E. Buring, Yu Chen, A. Heather Eliassen, J. Michael Gaziano, Jonathan N. Hofmann, Wen‐Yi Huang, Jae H. Kang, Jill Koshiol, Erikka Loftfield, I‐Min Lee, Steven C. Moore, Lorelei A. Mucci, Marian L. Neuhouser, Christina C. Newton, Mark P. Purdue, Howard D. Sesso, Martha Shrubsole, Rashmi Sinha, Lesley Tinker, Matthew Triplette, Caroline Y. Um, Kala Visvanathan, Eleanor L. Watts, Jean Wactawski‐Wende, Walter Willett, Fen Wu, Wei Zheng, Dinesh Barupal, Jessica L. Petrick, Katherine A. McGlynn   +36 more
wiley   +1 more source

Seroprevalence of Hepatitis B Virus Infection Among Patients Attending at Addis Alem Primary Hospital, Bahir Dar, Northwest Ethiopia

International Journal of General Medicine, 2021
Mekuanint Geta,1 Endalew Yizengaw,2 Zegeye Getaneh,3 Tamyalew Getahun4 1Department of Medical Microbiology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia; 2Departments of ...
Geta M, Yizengaw E, Getaneh Z, Getahun T
doaj