Results 271 to 280 of about 342,150 (384)

Interferon-γ and Tumor Necrosis Factor-α Produced by T Cells Reduce the HBV Persistence Form, cccDNA, Without Cytolysis.

open access: yesGastroenterology, 2016
Yuchen Xia   +20 more
semanticscholar   +1 more source

Employment Status of Patients With Liver Disease: A Nationwide Questionnaire Survey in Japan

open access: yesHepatology Research, EarlyView.
In our nationwide survey, analyzing over 2000 patients, those with viral hepatitis were less likely to disclose their condition, and overall awareness of support programs remained limited. These findings highlight the need to promote support for balancing treatment and work more actively, particularly in small‐ and medium‐sized workplaces.
Yoshio Tokumoto   +30 more
wiley   +1 more source

Efficacy and Safety of Hypofractionated Radiation Therapy Combined With Immunotherapy for Hepatocellular Carcinoma With Vp4 Portal Vein Tumor Thrombosis

open access: yesHepatology Research, EarlyView.
ABSTRACT Background Hepatocellular carcinoma (HCC) with Vp4 portal vein tumor thrombosis (PVTT) has an extremely poor prognosis, and evidence for effective systemic therapy is limited. Preclinical studies suggest that hypofractionated radiation therapy (HFRT) may enhance immune checkpoint inhibitor (ICI) efficacy through immunogenic cell death and ...
Masahiko Tameda   +11 more
wiley   +1 more source

Population‐Based Molecular Surveillance of Hepatitis B Virus Genotypes in the Goto Islands, Japan: A Three Decade Study (1977–2008) of 916 Carriers

open access: yesHepatology Research, EarlyView.
ABSTRACT Aims Understanding the molecular characteristics and genotype distribution of hepatitis B virus (HBV) is essential to elucidate intra and inter community transmission routes, identify cluster cases, and assess clinical implications based on genotype‐specific virulence.
Ko Ko   +10 more
wiley   +1 more source

mRNA vaccines for HBV: Mechanisms, preclinical advances, and therapeutic clinical progress. [PDF]

open access: yesMol Ther Nucleic Acids
Pechnikova NA   +6 more
europepmc   +1 more source

Clinical Outcomes of Reduced‐Dose Cabozantinib as Third‐ or Later‐Line Therapy After Immune Checkpoint Inhibitors in Advanced Hepatocellular Carcinoma: A Real‐World Study

open access: yesHepatology Research, EarlyView.
In this real‐world post‐ICI setting, cabozantinib demonstrated meaningful clinical activity even at reduced doses, with disease control achieved in nearly half of patients. Importantly, preserved liver function (Child–Pugh class A) was the only determinant of both disease control and overall survival.
Teiji Kuzuya   +13 more
wiley   +1 more source

Optimization of lipid nanoparticles loaded with ribonucleoprotein-oligonucleotide complexes for in vivo delivery of a CRISPR/Cas9 system targeting hepatitis B virus. [PDF]

open access: yesVirus Res
Akhter R   +11 more
europepmc   +1 more source

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