Results 291 to 300 of about 325,525 (350)

HBV induced hepatocellular carcinoma and related potential immunotherapy.

Pharmacological Research, 2020
Chronic infection of Hepatitis B virus (HBV) has long been recognized as a major risk factor in the initiation and development of hepatocellular carcinoma (HCC), contributing to over half the cases of HCC worldwide.
Liyang Jia, Yanan Gao, Yaowu He, J. Hooper, Pengyuan Yang   +4 more
semanticscholar   +1 more source

Development of anti-HBV agents targeting HBV capsid proteins

RSC Medicinal Chemistry, 2023
>Design and synthesis of anti-hepatitis B virus (HBV) agents: A small anti-HBV compound, Cpd4 (1), was identified by in silico screening. Its structure–activity relationship studies discovered a more potent derivative, TKB-HBV-CA-001 (3b).
Takuya Kobayakawa, Masayuki Amano, Miyuki Nakayama, Kohei Tsuji, Takahiro Ishii, Yutaro Miura, Kouki Shinohara, Kenichi Yamamoto, Masao Matsuoka, Hirokazu Tamamura   +9 more
openaire   +2 more sources

HBV induced carcinogenesis

Journal of Clinical Virology, 2005
Hepatocellular carcinoma (HCC) is one of the rare human neoplasms associated with viral infections. Hepatitis B virus (HBV) and hepatitis C virus (HCV) are the most important etiological factors of HCC, accounting for more than 70% of cases worldwide. The risk of HCC development is greatly increased in chronic viral carriers exposed to other recognized
Delphine, Cougot, Christine, Neuveut, Marie Annick, Buendia   +2 more
openaire   +2 more sources

The role of HBV-induced autophagy in HBV replication and HBV related-HCC

Life Sciences, 2018
Hepatitis B virus (HBV) is infecting about 364 million people around the world. It can cause various diseases, such as chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma (HCC). However, the present anti-viral treatment in clinics is limited; studies for new therapies are highly desired.
Mingjie Xie, Zhenggang Yang, Yanning Liu, Min Zheng   +3 more
openaire   +2 more sources

Mechanisms of HBV immune evasion.

Antiviral Research, 2020
The concept of immune evasion is a longstanding topic of debate during chronic Hepatitis B Virus infection. The 292 million individuals chronically infected by HBV are clear evidence that the virus avoids elimination by the immune system.
A. Kuipery, A. Gehring, M. Isogawa
semanticscholar   +1 more source

Adoptive T-cell therapy for HBV-associated HCC and HBV infection.

Antiviral Research, 2020
Chronic hepatitis B virus (HBV) infection remains a major global concern due to its high prevalence and the increased probability of progressing toward cirrhosis and hepatocellular carcinoma (HCC).
A. Tan, S. Schreiber
semanticscholar   +1 more source

HBV plus HCV, HCV plus HIV, HBV plus HIV

Current Gastroenterology Reports, 2006
Coinfection of hepatitis C virus (HCV), hepatitis B virus (HBV), and HIV is common due to shared modes of transmission. These coinfections accelerate the course of chronic liver disease and facilitate progression to cirrhosis and hepatocellular carcinoma.
James S, Park, Neeraj, Saraf, Douglas T, Dieterich   +2 more
openaire   +2 more sources

Interpretation of HBV Serologies

Clinics in Liver Disease, 2021
Hepatitis B was discovered by researchers who were investigating jaundice associated with blood transfusions as well as parenterally administered medications. Through trial and error, the HBV was identified. There are specific tests that detect HBV infection, whether it is a previous exposure or active infection. The various HBV serologies are reviewed
Philippe J, Zamor, Ashley M, Lane
openaire   +2 more sources

TNF-α/IFN-γ profile of HBV-specific CD4 T cells is associated with liver damage and viral clearance in chronic HBV infection.

Journal of Hepatology, 2019
BACKGROUND & AIMS The role of Hepatitis B virus (HBV)-specific CD4 T cells in chronic HBV infection patients is not clear. METHODS Through intracellular IFN-γ and TNF-α staining, HBV-specific CD4 T cells were analyzed in 68 chronic HBV infection ...
Haoliang Wang, Heng Luo, Xing Wan, Xiao-lan Fu, Q. Mao, Xiaomei Xiang, Yi Zhou, Weiwei He, Juan Zhang, Yanzhi Guo, W. Tan, Guohong Deng   +11 more
semanticscholar   +1 more source

Quantitation of HBV cccDNA in anti-HBc-positive liver donors by droplet digital PCR: A new tool to detect occult infection.

Journal of Hepatology, 2018
BACKGROUND & AIMS The accurate diagnosis of occult hepatitis B virus (HBV) infection (OBI) requires the demonstration of HBV DNA in liver biopsies of hepatitis B surface antigen-negative individuals.
G. Caviglia, M. Abate, F. Tandoi, A. Ciancio, A. Amoroso, M. Salizzoni, G. Saracco, M. Rizzetto, R. Romagnoli, A. Smedile   +9 more
semanticscholar   +1 more source