Results 181 to 190 of about 2,433,705 (252)

Antiviral Therapy Reduces Hepatocellular Carcinoma Recurrence in Patients With Low HBV-DNA Levels: A Randomized Controlled Trial

Annals of Surgery, 2018
Background: Despite antiviral treatment has been shown to reduce hepatocellular carcinoma (HCC) recurrence after curative treatment for hepatitis B virus (HBV)-related HCC in patients with high preoperative HBV-DNA levels, it is still unclear whether ...
Gang Huang, Peng-peng Li, W. Lau, Z. Pan, Ling-hao Zhao, Zhen-guang Wang, Meng-chao Wang, Weiping Zhou   +7 more
semanticscholar   +1 more source

A highly sensitive and stable electrochemical HBV DNA biosensor based on ErGO-supported Cu-MOF

, 2020
It is still a very challenging work to develop new and more effective methods for detecting Hepatitis B virus (HBV). In this work, a new simple electrochemical biosensor with high sensitivity and stability was constructed for detecting HBV DNA by ...
Xiaofeng Lin, Xin Lian, Binbin Luo, Xiao-Chun Huang   +3 more
semanticscholar   +1 more source

Blood Screening for HBV DNA

Journal of Clinical Virology, 2006
The safety of the blood supply has been greatly improved in the past two decades owing to continuous improvement in the technology and sensitivity of laboratory testing, better donor education and selection, and tighter quality control on blood bank operations.
openaire   +2 more sources

Cloned HBV DNA causes hepatitis in chimpanzees

Nature, 1982
Most of our knowledge of the structure and function of the hepatitis B virus (HBV) genome comes from the analysis of the viral DNA sequences cloned in bacteria1–3. Because the physical state of cloned HBV DNA differs from HBV DNA encapsidated in the virion—for example, it lacks the nick-gap structure4, and a covalently linked protein5—the question ...
H, Will, R, Cattaneo, H G, Koch, G, Darai, H, Schaller, H, Schellekens, P M, van Eerd, F, Deinhardt   +7 more
openaire   +2 more sources

Developing a sensitive HBV genotyping assay for HBV DNA suppressed patients using both DNA and RNA sequencing

Journal of Hepatology, 2020
AbstractHepatitis B virus (HBV) genotypes impact treatment outcomes and disease progression. The current genotyping methods have limitations in patients with low HBV viral load. In this study, a more sensitive assay has been developed for determining the HBV genotype in HBV DNA suppressed patients.
Yang Liu, Lindsey May, Xinan Liu, Ross Martin, Evguenia Svarovskaia, Anuj Gaggar, Hongmei Mo, Becket Feierbach   +7 more
openaire   +2 more sources

A novel, small anti-HBV compound reduces HBsAg and HBV-DNA by destabilizing HBV-RNA

Journal of Gastroenterology
Currently, standard treatments for chronic hepatitis B such as nucleos(t)ide analogs (NAs), effectively reduce hepatitis B virus (HBV) loads but rarely result in a functional cure (defined as sustained HBsAg loss). We report the discovery of a novel, 4-pyridone compound, SAG-524, a potent and orally bioavailable small molecule inhibitor of HBV ...
Takehisa Watanabe, Sanae Hayashi, Yan Zhaoyu, Hiroki Inada, Katsuya Nagaoka, Masakuni Tateyama, Yasuhito Tanaka   +6 more
openaire   +2 more sources

State of HBV DNA in HBsAg‐negative, anti‐HCV‐positive hepatocellular carcinoma: Existence of HBV DNA possibly as nonintegrated form with analysis by Alu‐HBV DNA PCR and conventional HBV PCR

Journal of Medical Virology, 2001
AbstractThe role of hepatitis B virus (HBV) in carcinogenesis of hepatitis B surface antigen (HBsAg)‐negative, anti‐hepatitis C virus (anti‐HCV)‐positive hepatocellular carcinoma (HCC) remains unknown. To investigate the state of HBV DNA in such HCC, HBV DNA was examined by polymerase chain reaction (PCR) between HBV DNA and human Alu sequence (HBV‐Alu
S, Kawai, O, Yokosuka, F, Imazeki, Y, Maru, H, Saisho   +4 more
openaire   +2 more sources

Evaluation of salivary beta-2 microglobulin as HBV proliferation marker in HBS Ag(+), HBV DNA PCR(+) and HBV DNA PCR(-) subjects.

Gastroenterology and hepatology from bed to bench, 2013
The aim of this study was to determine the concentration of salivary B2M as a marker of viral proliferation in HBS Ag(+), HBV DNA PCR(+) and Hbs Ag(+) and HBV DNA PCR(-) subjects.Beta-2 microglobulin (B2M) is responsible for transmission of viral antigens such as Hepatitis B (HBV) on the surface of liver cells as part of an HLA complex.In this case ...
Abdolsamadi, Hamidreza, Eini, Peiman, Ronasi, Negin, Kaboli, Seyed Alireza, Hajilooei, Mehrdad, MoghimBeigi, Abbas, Davoudi, Poorandokht, AhmadiMotemayel, Fatemeh, Mohaghegh Shalmani, Hamid   +8 more
openaire   +2 more sources

Residual HBV DNA and pgRNA viraemia is associated with hepatocellular carcinoma in chronic hepatitis B patients on antiviral therapy

Journal of gastroenterology, 2021
L. Mak, Qi Huang, D. Wong, L. Stamm, K. Cheung, Kwan-Lung Ko, R. Yan, Lea Ouyang, J. Fung, W. Seto, M. Yuen   +10 more
semanticscholar   +1 more source

STUDY OF HBEAG, HBV DNA IN PATIENTS WITH HBV- RELATED CIRRHOSIS

Journal of Medicine and Pharmacy, 2012
Background: The recent studies concerning antiviral therapy in HBV-related cirrhosis showed the promising results. This study aimed to assess /The aim of this study was to assess the quantity of HBeAg, HBV DNA and identify some related factors in patients with HBV-induced cirrhosis.
Van Huy Tran, Thi Thuan Nguyen, Viet Quynh Tram Ngo   +2 more
openaire   +1 more source