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The Effect of Low HBV-DNA Viral Load on Recurrence in Hepatocellular Carcinoma Patients Who Underwent Primary Locoregional Treatment and the Development of a Nomogram Prediction Model. [PDF]

Microorganisms
Xiong Y, Wang Z, Liu J, Li K, Zhang Y.
europepmc   +1 more source

HBcrAg-based risk score performs better than the HBV DNA-based scores for HCC prediction in grey zone patients who are HBeAg-negative. [PDF]

JHEP Rep
Tseng TC, Hosaka T, Liu CJ, Suzuki F, Chiang C, Hong CM, Kumada H, Yang WT, Su TH, Yang HC, Liu CH, Chen PJ, Kao JH.   +12 more
europepmc   +1 more source

Diagnostic precision of Truenat® technique and co-relation of ALT levels with HBV-DNA viral load among HBsAg positive patients at a tertiary care hospital in Eastern Uttar Pradesh. [PDF]

Iran J Microbiol
Kumari S, Gautam BK, Singh AK, Gaur V, Kumar A.   +4 more
europepmc   +1 more source

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Antiviral Therapy Reduces Hepatocellular Carcinoma Recurrence in Patients With Low HBV-DNA Levels: A Randomized Controlled Trial

Annals of Surgery, 2018
Background: Despite antiviral treatment has been shown to reduce hepatocellular carcinoma (HCC) recurrence after curative treatment for hepatitis B virus (HBV)-related HCC in patients with high preoperative HBV-DNA levels, it is still unclear whether ...
Gang Huang, Peng-peng Li, W. Lau, Z. Pan, Ling-hao Zhao, Zhen-guang Wang, Meng-chao Wang, Weiping Zhou   +7 more
semanticscholar   +1 more source

Enhanced Electrochemical Activity of a Hollow Carbon Sphere/Polyaniline-Based Electrochemical Biosensor for HBV DNA Marker Detection.

ACS Biomaterials Science & Engineering, 2019
Herein, we present a novel, simple, and ultrasensitive electrochemical DNA (E-DNA) sensor based on hollow carbon spheres (HCS) decorated with polyaniline (PANI).
Razieh Salimian, S. Shahrokhian, S. Panahi   +2 more
semanticscholar   +1 more source

Blood Screening for HBV DNA

Journal of Clinical Virology, 2006
The safety of the blood supply has been greatly improved in the past two decades owing to continuous improvement in the technology and sensitivity of laboratory testing, better donor education and selection, and tighter quality control on blood bank operations.
openaire   +2 more sources

APOBEC3B edits HBV DNA and inhibits HBV replication during reverse transcription

Antiviral Research, 2018
Hepatitis B virus is a partially double-stranded DNA virus that replicates by reverse transcription, which occurs within viral core particles in the cytoplasm. The cytidine deaminase APOBEC3B is a cellular restriction factor for HBV. Recently, it was reported that APOBEC3B can edit HBV cccDNA in the nucleus, causing its degradation.
Yanmeng, Chen, Jie, Hu, Xuefei, Cai, Yao, Huang, Xing, Zhou, Zeng, Tu, Jieli, Hu, John E, Tavis, Ni, Tang, Ailong, Huang, Yuan, Hu   +10 more
openaire   +2 more sources

Cloned HBV DNA causes hepatitis in chimpanzees

Nature, 1982
Most of our knowledge of the structure and function of the hepatitis B virus (HBV) genome comes from the analysis of the viral DNA sequences cloned in bacteria1–3. Because the physical state of cloned HBV DNA differs from HBV DNA encapsidated in the virion—for example, it lacks the nick-gap structure4, and a covalently linked protein5—the question ...
H, Will, R, Cattaneo, H G, Koch, G, Darai, H, Schaller, H, Schellekens, P M, van Eerd, F, Deinhardt   +7 more
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Developing a sensitive HBV genotyping assay for HBV DNA suppressed patients using both DNA and RNA sequencing

Journal of Hepatology, 2020
AbstractHepatitis B virus (HBV) genotypes impact treatment outcomes and disease progression. The current genotyping methods have limitations in patients with low HBV viral load. In this study, a more sensitive assay has been developed for determining the HBV genotype in HBV DNA suppressed patients.
Yang Liu, Lindsey May, Xinan Liu, Ross Martin, Evguenia Svarovskaia, Anuj Gaggar, Hongmei Mo, Becket Feierbach   +7 more
openaire   +2 more sources

A novel, small anti-HBV compound reduces HBsAg and HBV-DNA by destabilizing HBV-RNA

Journal of Gastroenterology
Currently, standard treatments for chronic hepatitis B such as nucleos(t)ide analogs (NAs), effectively reduce hepatitis B virus (HBV) loads but rarely result in a functional cure (defined as sustained HBsAg loss). We report the discovery of a novel, 4-pyridone compound, SAG-524, a potent and orally bioavailable small molecule inhibitor of HBV ...
Takehisa Watanabe, Sanae Hayashi, Yan Zhaoyu, Hiroki Inada, Katsuya Nagaoka, Masakuni Tateyama, Yasuhito Tanaka   +6 more
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