Results 131 to 140 of about 29,456 (266)

A Service Evaluation of a Specialist Multi‐Disciplinary Weight Management Service Based in Primary Care Including Long‐Term Follow‐Up Data

Clinical Obesity, Volume 16, Issue 4, August 2026.
ABSTRACT This service evaluation of a primary care‐based specialist weight management service reports data from 1094 patients over 5 years (2014–2019), including weight data at 1‐year post‐discharge. The results show clinically and statistically significant improvements in weight, diet, physical activity, quality of life, blood pressure and blood ...
Helen M. Parretti, Carly A. Hughes, Sally Erskine, Nicholas Steel, Amy Jennings   +4 more
wiley   +1 more source

Glycosyl Coumarins as Selective Inhibitors of Tumor-Associated Carbonic Anhydrase IX and XII: Synthesis, Structure-Activity Relationships, and Molecular Modeling. [PDF]

Int J Mol Sci
Le Pors MS, Aznar I, Giovannuzzi S, Supuran CT, Lavecchia MJ, Colinas PA.   +5 more
europepmc   +1 more source

Alternative Breakfast Service Models Are Associated With Greater Student School Breakfast Participation: Evidence From Middle and High School Students Across 8 States

Journal of School Health, Volume 96, Issue 8, August 2026.
ABSTRACT Background Eating school breakfast has benefits for students, yet participation remains lower than that of school lunch. This study examined associations between school breakfast service models, self‐reported participation, and perceived participation barriers, and whether these associations differed by school level (middle vs.
Monica D. Zuercher, Dania Orta‐Aleman, Cailin D. French, Chrisina A. Hecht, Kenneth Hecht, Juliana F. W. Cohen, Punam Ohri‐Vachaspati, Anisha I. Patel, Lorrene D. Ritchie, Wendi Gosliner   +9 more
wiley   +1 more source

Medical Education as Both Process and Environment for Innovation. [PDF]

HCA Healthc J Med
Wickham G.
europepmc   +1 more source

Rhizobacteria‐Induced Systemic Priming Against Fungal Pathogens Involves Hydroxycinnamic Acid Amides

Plant, Cell &Environment, Volume 49, Issue 8, Page 4907-4921, August 2026.
ABSTRACT The rhizosphere, a narrow region of soil surrounding roots, contains diverse microorganisms with a composition that is distinct from the surrounding soil. Some rhizosphere bacteria can trigger a heightened state of immunity in the whole plant, termed Induced Systemic Resistance (ISR).
Mackenzie Eli William Loranger, Wolfgang Moeder, Hyunsuh Lee, David K. Liscombe, Eric Déziel, Keiko Yoshioka   +5 more
wiley   +1 more source

Fragment-Derived Nicotinic Acid Analogues Inhibit hCA III and Downregulate <i>CA3</i> Expression in HepG2 Cells. [PDF]

Biomolecules
Abuhammad A, Sabri T, Ababneh NA, Ali RA, Ismail MA, Madadha A, Yazjeen DT, Alghanem RJ, Qaisi AM, Al-Hiari Y, Gupta K, Berger I, Sim E.   +12 more
europepmc   +1 more source

Investigating the Inhibitory Properties of Diazo and Pyrazole‐Carboxamide‐Linked Benzenesulfonamides Against Carbonic Anhydrase Isoforms I, II, IX, and XII

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
Hybrid diazo‐ and pyrazole‐carboxamide benzenesulfonamides emerge as highly potent and selective inhibitors of tumor‐associated carbonic anhydrases. A 3,4‐dichloro‐substituted derivative achieves sub‐2 nM inhibition of hCA IX and displays promising anticancer activity, revealing a valuable scaffold for the development of next‐generation cancer‐targeted
Suleyman Akocak, Nebih Lolak, Andrea Ammara, Gökçenur Gürbüz, Ibrahim Bozgeyik, Demet Taşdemir, Hamada Hashem, Stefan Bräse, Claudiu T. Supuran   +8 more
wiley   +1 more source

Discovery of a Mixed and Prodrug-Like Inhibition Mechanism for Phosphocoumarins and Phosphoquinolinones against Human Carbonic Anhydrases. [PDF]

J Med Chem
Nocentini A, Giovannuzzi S, Alterio V, Bonardi A, Barons R, Zalubovskis R, Eldehna WM, Aronne R, Esposito D, Luchinat E, De Simone G, Bartolucci G, Gratteri P, Mori M, Supuran CT.   +14 more
europepmc   +1 more source

Furagin Derivatives—Nitrofuran‐Based Hydrazones as Potential Dual Inhibitors of Thioredoxin Reductase and Carbonic Anhydrases

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
Nitrofuran‐based hydrazones derived from furagin are developed as dual inhibitors of thioredoxin reductase 1 and cancer‐associated carbonic anhydrases IX and XII. The series shows selective enzyme inhibition with reduced off‐target carbonic anhydrase (CA) I/II activity, while lead compound 7g exhibits potent TrxR1 inhibition and moderate anticancer ...
Aleksandrs Pustenko, Raitis Bobrovs, Katrīna Freimane, Antons Sizovs, Andrea Angeli, Claudiu T. Supuran, Raivis Žalubovskis   +6 more
wiley   +1 more source

p-Aminobenzene-Sulfonamide Derivatives of Substituted Pyrimidines as Human Carbonic Anhydrase Inhibitors. [PDF]

Int J Mol Sci
Angeli A, Petrou A, Kartcev V, Prezent M, Sirakanyan S, Geronikaki A, Supuran CT.   +6 more
europepmc   +1 more source