Results 1 to 10 of about 2,899,786 (186)
Carbonic Anhydrases and Metabolism [PDF]
Metabolites, 2018 Although the role of carbonic anhydrases (CAs, EC 4.2.1.1) in metabolism is well-established, pharmacological applications of this phenomenon started to be considered only recently.
Claudiu T. Supuran
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Multivalent Carbonic Anhydrases Inhibitors [PDF]
International Journal of Molecular Sciences, 2019 Biomolecular recognition using a multivalent strategy has been successfully applied, this last decade on several biological targets, especially carbohydrate-processing enzymes, proteases, and phosphorylases.
Fabrizio Carta +2 more
exaly +5 more sources
An Overview of the Bacterial Carbonic Anhydrases
Metabolites, 2017 Bacteria encode carbonic anhydrases (CAs, EC 4.2.1.1) belonging to three different genetic families, the α-, β-, and γ-classes. By equilibrating CO2 and bicarbonate, these metalloenzymes interfere with pH regulation and other crucial physiological ...
Clemente Capasso, Claudiu Supuran
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Carbonic Anhydrases: Role in pH Control and Cancer
Metabolites, 2018 The pH of the tumor microenvironment drives the metastatic phenotype and chemotherapeutic resistance of tumors. Understanding the mechanisms underlying this pH-dependent phenomenon will lead to improved drug delivery and allow the identification of new ...
Mam Mboge +2 more
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Journal of Enzyme Inhibition and Medicinal Chemistry, 2018 A series of 6-substituted ureido- and thioureido-benzoxaboroles were investigated as inhibitors of carbonic anhydrases from Trypanosoma cruzi (TcCA), and Leishmania donovani chagasi (LdcCA). Both enzymes were inhibited by benzoxaboroles in the micromolar
Pascal Dumy +2 more
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Breast Cancer Research, 2023 Background Carbonic anhydrases catalyze CO2/HCO3 – buffer reactions with implications for effective H+ mobility, pH dynamics, and cellular acid–base sensing.
Soojung Lee +13 more
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An overview on the recently discovered iota-carbonic anhydrases
Journal of Enzyme Inhibition and Medicinal Chemistry, 2021 Carbonic anhydrases (CAs, EC 4.2.1.1) have been studied for decades and have been classified as a superfamily of enzymes which includes, up to date, eight gene families or classes indicated with the Greek letters α, β, γ, δ, ζ, η, θ, ι.
Clemente Capasso +2 more
exaly +2 more sources
Carbonic Anhydrases in Photosynthesizing Cells of C3 Higher Plants
Metabolites, 2019 The review presents data on the location, nature, properties, number, and expression of carbonic anhydrase genes in the photosynthesizing cells of C3 plants.
Lyudmila Ignatova +4 more
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Brucella suis carbonic anhydrases and their inhibitors: Towards alternative antibiotics?
Journal of Enzyme Inhibition and Medicinal Chemistry, 2017 Carbonic anhydrases have started to emerge as new potential antibacterial targets for several pathogens. Two β-carbonic anhydrases, denominated bsCA I and bsCA II, have been isolated and characterized from the bacterial pathogen Brucella suis, the ...
Stephan Köhler +2 more
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Systematic modeling of porphyrin-based photosensitizers for inhibiting Mycobacterium tuberculosis β-Carbonic Anhydrases [PDF]
Scientific ReportsMycobacterium tuberculosis β-carbonic anhydrases (Mtb-CAs) are zinc-dependent enzymes that play a role in intracellular pH regulation and bacterial physiology within the host.
Ajay Manaithiya +9 more
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