Results 1 to 10 of about 7,272 (219)

Quantitative Characterization of the Chemical Space Governed by Human Carbonic Anhydrases and selenium-containing derivatives of solfonamides [PDF]

Brazilian Journal of Pharmaceutical Sciences, 2022
Due to the fact that different isoforms of carbonic anhydrase play distinct physiological roles, their diseases/disorders involvement are different as well.
Behnam Rasti
doaj   +1 more source

Carbonic anhydrases reduce the acidity of the tumor microenvironment, promote immune infiltration, decelerate tumor growth, and improve survival in ErbB2/HER2-enriched breast cancer

Breast Cancer Research, 2023
Background Carbonic anhydrases catalyze CO2/HCO3 – buffer reactions with implications for effective H+ mobility, pH dynamics, and cellular acid–base sensing.
Soojung Lee, Nicolai J. Toft, Trine V. Axelsen, Maria Sofia Espejo, Tina M. Pedersen, Marco Mele, Helene L. Pedersen, Eva Balling, Tonje Johansen, Mark Burton, Mads Thomassen, Pernille Vahl, Peer Christiansen, Ebbe Boedtkjer   +13 more
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Ureidobenzenesulfonamides as Selective Carbonic Anhydrase I, IX, and XII Inhibitors

Molecules, 2023
Sulfonamides remain an important class of drugs, especially because of their inhibitory effects on carbonic anhydrases. Herein, we have synthesized several sulfonamides and tested them for their inhibitory activity against carbonic anhydrases hCA I, hCA ...
Toni C. Denner, Andrea Angeli, Marta Ferraroni, Claudiu T. Supuran, René Csuk   +4 more
doaj   +1 more source

Carbonic anhydrases CA1 and CA4 function in atmospheric CO2-modulated disease resistance [PDF]

, 2020
Main conclusion Carbonic anhydrases CA1 and CA4 attenuate plant immunity and can contribute to altered disease resistance levels in response to changing atmospheric CO2 conditions.
Pieterse, Corné M. J., Van Der Does, Dieuwertje, Van Dijken, Anja J. H., Van Wees, Saskia C. M., Vroegop-vos, Irene A., Zhou, Yeling, Zipfel, Cyril   +6 more
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Structural Basis for the Inhibition of Helicobacter pylori α-Carbonic Anhydrase by Sulfonamides. [PDF]

PLoS ONE, 2015
Periplasmic α-carbonic anhydrase of Helicobacter pylori (HpαCA), an oncogenic bacterium in the human stomach, is essential for its acclimation to low pH. It catalyses the conversion of carbon dioxide to bicarbonate using Zn(II) as the cofactor.
Joyanta K Modak, Yu C Liu, Mayra A Machuca, Claudiu T Supuran, Anna Roujeinikova   +4 more
doaj   +1 more source

Acipimox inhibits human carbonic anhydrases

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
Acipimox, a nicotinic acid derivative in clinical use for the treatment of hyperlipidaemia, incorporates a free carboxylic acid and an N-oxide moiety, functionalities known to interact with the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1) and ...
Mattia Mori, Claudiu T. Supuran
doaj   +1 more source

Novel thiazolone-benzenesulphonamide inhibitors of human and bacterial carbonic anhydrases

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
A small library of novel thiazolone-benzenesulphonamides has been prepared and evaluated for their ability to inhibit three human cytosolic carbonic anhydrases (hCA I, hCA II, and hCA VII) and three bacterial carbonic anhydrases (MscCAβ, StCA1, and StCA2)
Morteza Abdoli, Viviana De Luca, Clemente Capasso, Claudiu T. Supuran, Raivis Žalubovskis   +4 more
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Mitochondrial proteomic profiling reveals increased carbonic anhydrase II in aging and neurodegeneration [PDF]

, 2016
Carbonic anhydrase inhibitors are used to treat glaucoma and cancers. Carbonic anhydrases perform a crucial role in the conversion of carbon dioxide and water into bicarbonate and protons.
Beal, Burkhard, Béchet, Chakrabarti, Corvin, Crowston, Edsall, Farrer, Fliegel, Fox, Ganie, Greenwald, Griffiths, Hansson, Hoyer, Hu, Izzotti, Jackson, Jacobson, Kassab, La Spada, La Spada, La Spada, Larsson, Levine, MacCoss, Masereel, Munnich, Nehrke, Ohlendieck, Ohlendieck, Perreault, Protasi, Rostagno, Schrattenholz, Serrano, Setou, Song, Stiernagle, Supuran, Supuran, Swenson, Swietach, Vieta, Worrall, Zhou   +45 more
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Prokaryotic carbonic anhydrases [PDF]

FEMS Microbiology Reviews, 2000
Carbonic anhydrases catalyze the reversible hydration of CO(2) [CO(2)+H(2)Oright harpoon over left harpoon HCO(3)(-)+H(+)]. Since the discovery of this zinc (Zn) metalloenzyme in erythrocytes over 65 years ago, carbonic anhydrase has not only been found in virtually all mammalian tissues but is also abundant in plants and green unicellular algae.
K S, Smith, J G, Ferry
openaire   +2 more sources

Active Nanointerfaces Based on Enzyme Carbonic Anhydrase and Metal–Organic Framework for Carbon Dioxide Reduction

Nanomaterials, 2021
Carbonic anhydrases are enzymes capable of transforming carbon dioxide into bicarbonate to maintain functionality of biological systems. Synthetic isolation and implementation of carbonic anhydrases into membrane have recently raised hopes for emerging ...
Qian Liu, Xinwei Bai, Huy Pham, Jianli Hu, Cerasela Zoica Dinu   +4 more
doaj   +1 more source