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Carbonic Anhydrases and Metabolism [PDF]
Metabolites, 2018 Although the role of carbonic anhydrases (CAs, EC 4.2.1.1) in metabolism is well-established, pharmacological applications of this phenomenon started to be considered only recently.
Claudiu T. Supuran
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Carbonic Anhydrases: Different Active Sites, Same Metal Selectivity Rules [PDF]
MoleculesCarbonic anhydrases are mononuclear metalloenzymes catalyzing the reversible hydration of carbon dioxide in organisms belonging to all three domains of life.
Nikoleta Kircheva +2 more
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Journal of Enzyme Inhibition and Medicinal Chemistry, 2018 A series of 6-substituted ureido- and thioureido-benzoxaboroles were investigated as inhibitors of carbonic anhydrases from Trypanosoma cruzi (TcCA), and Leishmania donovani chagasi (LdcCA). Both enzymes were inhibited by benzoxaboroles in the micromolar
Alessio Nocentini +2 more
exaly +3 more sources
Polyamines and α-Carbonic Anhydrases [PDF]
Molecules, 2016 Natural products represent a straightforward source for molecular structures bearing a vast array of chemical features and potentially useful for biomedical purposes.
Andrea Scozzafava +2 more
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An Overview of the Bacterial Carbonic Anhydrases
Metabolites, 2017 Bacteria encode carbonic anhydrases (CAs, EC 4.2.1.1) belonging to three different genetic families, the α-, β-, and γ-classes. By equilibrating CO2 and bicarbonate, these metalloenzymes interfere with pH regulation and other crucial physiological ...
Claudiu T Supuran +2 more
exaly +4 more sources
Carbonic Anhydrases in Photosynthesizing Cells of C3 Higher Plants
Metabolites, 2019 The review presents data on the location, nature, properties, number, and expression of carbonic anhydrase genes in the photosynthesizing cells of C3 plants.
Lyudmila Ignatova +4 more
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Brucella suis carbonic anhydrases and their inhibitors: Towards alternative antibiotics?
Journal of Enzyme Inhibition and Medicinal Chemistry, 2017 Carbonic anhydrases have started to emerge as new potential antibacterial targets for several pathogens. Two β-carbonic anhydrases, denominated bsCA I and bsCA II, have been isolated and characterized from the bacterial pathogen Brucella suis, the ...
Stephan Köhler +2 more
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Systematic modeling of porphyrin-based photosensitizers for inhibiting Mycobacterium tuberculosis β-Carbonic Anhydrases [PDF]
Scientific ReportsMycobacterium tuberculosis β-carbonic anhydrases (Mtb-CAs) are zinc-dependent enzymes that play a role in intracellular pH regulation and bacterial physiology within the host.
Ajay Manaithiya +9 more
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Novel thiazolone-benzenesulphonamide inhibitors of human and bacterial carbonic anhydrases [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 A small library of novel thiazolone-benzenesulphonamides has been prepared and evaluated for their ability to inhibit three human cytosolic carbonic anhydrases (hCA I, hCA II, and hCA VII) and three bacterial carbonic anhydrases (MscCAβ, StCA1, and StCA2)
Morteza Abdoli +4 more
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Plant Carbonic Anhydrases, their Role in Stress Defense and Possible Practical Use [PDF]
Journal of Stress Physiology & Biochemistry, 2018 The review presents data on the distribution of carbonic anhydrases in photosynthetic organisms and their location in cellular compartments. The functions of carbonic anhydrases to provide a high photosynthesis rate as well as their participation in ...
Rudenko N.N. +4 more
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