Results 21 to 30 of about 7,272 (219)

Plant Carbonic Anhydrases, their Role in Stress Defense and Possible Practical Use [PDF]

Journal of Stress Physiology & Biochemistry, 2018
The review presents data on the distribution of carbonic anhydrases in photosynthetic organisms and their location in cellular compartments. The functions of carbonic anhydrases to provide a high photosynthesis rate as well as their participation in ...
Rudenko N.N., Ignatova L.K., Zhurikova E.M., Novichkova N.S., Ivanov B.N.   +4 more
doaj  

Toll-like Receptor 3 Agonist, Polyinosinic-polycytidylic Acid, Upregulates Carbonic Anhydrase II in Human Keratinocytes

Acta Dermato-Venereologica, 2018
Carbonic anhydrases are ubiquitously expressed enzymes that reversibly hydrate carbon dioxide to bicarbonate and protons. While the main function of carbonic anhydrases is to regulate pH and osmotic balance, their involvement in other physiological ...
Bani Kaur Suri, Navin Kumar Verma, Artur Schmidtchen   +2 more
doaj   +1 more source

1,2,3-Benzoxathiazine-2,2-dioxides – effective inhibitors of human carbonic anhydrases

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
A series of 1,2,3-benzoxathiazine-2,2-dioxides possessing various substituents in the 5, 7, or 8 position was obtained from corresponding 2-hydroxybenzaldehydes in their reaction with sulfamoyl chloride.
Jekaterina Ivanova, Morteza Abdoli, Alessio Nocentini, Raivis Žalubovskis, Claudiu T. Supuran   +4 more
doaj   +1 more source

A glycosylphosphatidylinositol-anchored carbonic anhydrase-related protein of Toxoplasma gondii is important for rhoptry biogenesis and virulence [PDF]

, 2017
Carbonic anhydrase-related proteins (CARPs) have previously been described as catalytically inactive proteins closely related to α-carbonic anhydrases (α-CAs).
Beejan Asady, Isabelle Coppens, Jessica C. Kissinger, Leandro Lemgruber, Nathan M. Chasen, Rossiane C. Vommaro, Silvia N. J. Moreno, William J. Sullivan   +7 more
core   +2 more sources

Chemical probing suggests redox-regulation of the carbonic anhydrase activity of mycobacterial Rv1284 [PDF]

, 2015
The mycobacterial enzyme Rv1284 is a member of the ߭carbonic anhydrase family that is considered essential for survival of the pathogen. The active site cavity of this dimeric protein is characterized by an exceptionally small volume and harbours a ...
Abas, Adams, Betts, Bhat, Bryson, Brünger, Brünger, Chim, Collaborative Computational Project Number 4, Dolinsky, Ehrt, Emsley, Gnielinski, Hofmann, Hofmann, Jones, Kabsch, Kang, Khalifah, Kimber, Kumar, Lane, McPhillips, Radchenko, Rowlett, Sassetti, Schnappinger, Schoepfer, Shiloh, Suarez Covarrubias, Suarez Covarrubias, Thakur, Tripp, Voskuil, Wang, Wang, Wang, Wayne, Zimmerman   +38 more
core   +1 more source

Carbonic Anhydrases and Metabolism

Metabolites, 2018
Although the role of carbonic anhydrases (CAs, EC 4.2.1.1) in metabolism is well-established, pharmacological applications of this phenomenon started to be considered only recently.
Claudiu T. Supuran
doaj   +1 more source

Endocervical glandular neoplasia associated with lobular endocervical glandular hyperplasia is HPV-independent and correlates with carbonic anhydrase-IX expression: a Gynaecological Oncology Group Study. [PDF]

, 2013
BackgroundLobular endocervical glandular hyperplasia (LEGH) is a rare lesion of the uterine cervix. It has been proposed that LEGH may represent a precursor lesion to a group of mucinous adenocarcinoma with gastric phenotype (GA) that is independent of ...
Carter, R, Darcy, KM, Hatae, M, Kauderer, J, Liao, SY, Nagao, S, Rodgers, WH, Stanbridge, EJ, Susumu, N, Walker, JL   +9 more
core   +1 more source

Carbonic anhydrases from Trypanosoma cruzi and Leishmania donovani chagasi are inhibited by benzoxaboroles

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
A series of 6-substituted ureido- and thioureido-benzoxaboroles were investigated as inhibitors of carbonic anhydrases from Trypanosoma cruzi (TcCA), and Leishmania donovani chagasi (LdcCA). Both enzymes were inhibited by benzoxaboroles in the micromolar
Alessio Nocentini, Roberta Cadoni, Pascal Dumy, Claudiu T. Supuran, Jean-Yves Winum   +4 more
doaj   +1 more source

Insights into the role of reactive sulfhydryl groups of Carbonic Anhydrase III and VII during oxidative damage [PDF]

, 2016
Carbonic anhydrases (CAs) III and VII are two cytosolic isoforms of the α-CA family which catalyze the physiological reaction of carbon dioxide hydration to bicarbonate and proton.
De Simone, Giuseppina, Di Fiore, Anna, Langella, Emma, Monti, Daria M, Monti, Simona M, Supuran, Claudiu T   +5 more
core   +1 more source

Coumarins effectively inhibit bacterial α-carbonic anhydrases

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
Coumarins are known to act as prodrug inhibitors of mammalian α-carbonic anhydrases (CAs, EC 4.2.1.1) but they were not yet investigated for the inhibition of bacterial α-CAs.
Simone Giovannuzzi, Chad S. Hewitt, Alessio Nocentini, Clemente Capasso, Daniel P. Flaherty, Claudiu T. Supuran   +5 more
doaj   +1 more source