Results 21 to 30 of about 7,953 (283)

Carbonic anhydrases in fungi [PDF]

Microbiology, 2010
Carbonic anhydrases (CAs) are metalloenzymes that catalyse the interconversion of carbon dioxide and bicarbonate with high efficiency. This reaction is fundamental to biological processes such as respiration, photosynthesis, pH homeostasis, CO(2 ...
Elleuche, Skander, Poeggeler, Stefanie
core   +3 more sources

Carbonic Anhydrases: Role in pH Control and Cancer

Metabolites, 2018
The pH of the tumor microenvironment drives the metastatic phenotype and chemotherapeutic resistance of tumors. Understanding the mechanisms underlying this pH-dependent phenomenon will lead to improved drug delivery and allow the identification of new ...
Mam Y Mboge, Brian P Mahon, Robert Mckenna   +2 more
exaly   +3 more sources

Novel benzofuran-based sulphonamides as selective carbonic anhydrases IX and XII inhibitors: synthesis and in vitro biological evaluation

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Pursuing on our efforts toward searching for efficient hCA IX and hCA XII inhibitors, herein we report the design and synthesis of new sets of benzofuran-based sulphonamides (4a,b, 5a,b, 9a–c, and 10a–d), featuring the zinc anchoring benzenesulfonamide ...
Mohamed A Abdelrahman, Wagdy M Eldehna, Alessio Nocentini   +2 more
exaly   +2 more sources

Quantitative Characterization of the Chemical Space Governed by Human Carbonic Anhydrases and selenium-containing derivatives of solfonamides [PDF]

Brazilian Journal of Pharmaceutical Sciences, 2022
Due to the fact that different isoforms of carbonic anhydrase play distinct physiological roles, their diseases/disorders involvement are different as well.
Behnam Rasti
doaj   +1 more source

Carbonic anhydrases reduce the acidity of the tumor microenvironment, promote immune infiltration, decelerate tumor growth, and improve survival in ErbB2/HER2-enriched breast cancer

Breast Cancer Research, 2023
Background Carbonic anhydrases catalyze CO2/HCO3 – buffer reactions with implications for effective H+ mobility, pH dynamics, and cellular acid–base sensing.
Soojung Lee, Nicolai J. Toft, Trine V. Axelsen, Maria Sofia Espejo, Tina M. Pedersen, Marco Mele, Helene L. Pedersen, Eva Balling, Tonje Johansen, Mark Burton, Mads Thomassen, Pernille Vahl, Peer Christiansen, Ebbe Boedtkjer   +13 more
doaj   +1 more source

Ureidobenzenesulfonamides as Selective Carbonic Anhydrase I, IX, and XII Inhibitors

Molecules, 2023
Sulfonamides remain an important class of drugs, especially because of their inhibitory effects on carbonic anhydrases. Herein, we have synthesized several sulfonamides and tested them for their inhibitory activity against carbonic anhydrases hCA I, hCA ...
Toni C. Denner, Andrea Angeli, Marta Ferraroni, Claudiu T. Supuran, René Csuk   +4 more
doaj   +1 more source

Role of carbonic anhydrases in ferroptosis-resistance [PDF]

, 2020
Iron is essential for all the lives on earth but may trigger a switch toward ferroptosis, a novel form of regulated necrosis. Carbonic anhydrases (CAs) are ubiquitous enzymes from microbes to humans. The primary function of CAs is to regulate cellular pH
Li, Zan, Jiang, Li, Toyokuni, Shinya
core   +1 more source

Structural Basis for the Inhibition of Helicobacter pylori α-Carbonic Anhydrase by Sulfonamides. [PDF]

PLoS ONE, 2015
Periplasmic α-carbonic anhydrase of Helicobacter pylori (HpαCA), an oncogenic bacterium in the human stomach, is essential for its acclimation to low pH. It catalyses the conversion of carbon dioxide to bicarbonate using Zn(II) as the cofactor.
Joyanta K Modak, Yu C Liu, Mayra A Machuca, Claudiu T Supuran, Anna Roujeinikova   +4 more
doaj   +1 more source

Active Nanointerfaces Based on Enzyme Carbonic Anhydrase and Metal–Organic Framework for Carbon Dioxide Reduction

Nanomaterials, 2021
Carbonic anhydrases are enzymes capable of transforming carbon dioxide into bicarbonate to maintain functionality of biological systems. Synthetic isolation and implementation of carbonic anhydrases into membrane have recently raised hopes for emerging ...
Qian Liu, Xinwei Bai, Huy Pham, Jianli Hu, Cerasela Zoica Dinu   +4 more
doaj   +1 more source

Synthesis, Molecular Docking Analysis, ADMET and Drug Likeness Prediction of a Benzenesulfonamide Derivative Analogue of SLC-0111

Medical Sciences Forum, 2022
Carbonic anhydrases are metalloenzymes that regulate the interconversion of CO2 and H2CO3, a reaction involved in many physiological processes. A disfunction of these enzymes is known to induce many diseases such as glaucoma, epilepsy and cancer.
Yousra Ouafa Bouone, Abdeslem Bouzina, Nour-Eddine Aouf   +2 more
doaj   +1 more source