Results 31 to 40 of about 7,953 (283)

Exploring the Structural Diversity of Novel 3-Substituted Coumarins as Potent Inhibitors of Tumor-Associated Carbonic Anhydrases: Expanding the Pharmacological Space for Anticancer Drug Discovery

, 2023
Innovations in cancer chemotherapy continue to occupy the priority list of demands to ensure our health security. The vast chemical space provides a plethora of anticancer discovery opportunities, however, limited by the boundaries of synthetic ...
Sami, Al-Hussain, Sobhi, Gomha, Zeinab, Muhammad, Ahmed, El-khouly, Islam, Matar, Magdi, Zaki   +5 more
core   +1 more source

Bioinformatic analysis of beta carbonic anhydrase sequences from protozoans and metazoans

Parasites & Vectors, 2014
Background Despite the high prevalence of parasitic infections, and their impact on global health and economy, the number of drugs available to treat them is extremely limited.
Reza Zolfaghari Emameh, Harlan Barker, Martti E E Tolvanen, Csaba Ortutay, Seppo Parkkila   +4 more
doaj   +1 more source

Roles of Carbonic Anhydrases and Carbonic Anhydrases Related Proteins in Zebrafish

International Journal of Molecular Sciences, 2022
During the last decades, zebrafish (Danio rerio) has become one of the most important model organisms to study different physiological and biological phenomena. Research field of carbonic anhydrases (CAs) and carbonic anhydrase related proteins (CARPs) is not an exception in this.
Aspatwar Ashok, Parkkila Seppo, Syrjänen Leo   +2 more
openaire   +2 more sources

Evaluation of carbonic anhydrase IX as a therapeutic target for inhibition of breast cancer invasion and metastasis using a series of in vitro breast cancer models [PDF]

, 2015
This research was financed in part by a Grant of the 7th Framework Program of the European Union (METOXIA project; HEALTH‐F2‐2009‐222741) and the NGI Pre- Seed grant (NWO n° 93613002).Triple negative, resistant or metastatic disease are major factors in ...
Kunkler, Ian H., Jarman, Edward J, Kunkler, Ian, Pavathaneni, Nanda- Kumar, Meehan, James, Jarman, Edward, Ward, Carol, Harrison, David James, Langdon, Simon P., Dixon, J. Michael, Um, In Hwa, Supuran, Claudiu, Lambin, Philippe, Winum, Jean-Yves, Um, Inhwa, Dixon, MIchael, Supuran, Claudiu Trandafir, Renshaw, Lorna, Harrison, David J, Dubois, Ludwig, Langdon, Simon, Thomas, Jeremy, Mullen, Peter, Kay, Charlene, Jarman, Edward J., Kay, Charlene; id_orcid, Supuran, Claudiu T, Harrison, David, Pavathaneni, Nanda-Kumar, Thomas, Jeremy S., Harrison, David J.   +30 more
core   +1 more source

Toll-like Receptor 3 Agonist, Polyinosinic-polycytidylic Acid, Upregulates Carbonic Anhydrase II in Human Keratinocytes

Acta Dermato-Venereologica, 2018
Carbonic anhydrases are ubiquitously expressed enzymes that reversibly hydrate carbon dioxide to bicarbonate and protons. While the main function of carbonic anhydrases is to regulate pH and osmotic balance, their involvement in other physiological ...
Bani Kaur Suri, Navin Kumar Verma, Artur Schmidtchen   +2 more
doaj   +1 more source

Prokaryotic carbonic anhydrases [PDF]

FEMS Microbiology Reviews, 2000
Carbonic anhydrases catalyze the reversible hydration of CO(2) [CO(2)+H(2)Oright harpoon over left harpoon HCO(3)(-)+H(+)]. Since the discovery of this zinc (Zn) metalloenzyme in erythrocytes over 65 years ago, carbonic anhydrase has not only been found in virtually all mammalian tissues but is also abundant in plants and green unicellular algae.
K S, Smith, J G, Ferry
openaire   +2 more sources

Coumarins effectively inhibit bacterial α-carbonic anhydrases

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
Coumarins are known to act as prodrug inhibitors of mammalian α-carbonic anhydrases (CAs, EC 4.2.1.1) but they were not yet investigated for the inhibition of bacterial α-CAs.
Simone Giovannuzzi, Chad S. Hewitt, Alessio Nocentini, Clemente Capasso, Daniel P. Flaherty, Claudiu T. Supuran   +5 more
doaj   +1 more source

Role of carbon dioxide and ion transport in the formation of sub-embryonic fluid by the blastoderm of the Japanese quail

, 2002
1. The explanted blastoderm of the Japanese quail was used to explore the role of ions and carbon dioxide in determining the rate of sub-embryonic fluid (SEF) production between 54 and 72 h of incubation. 2.
Latter, G.V., Baggott, Glenn K.
core   +1 more source

Effect of egg turning and incubation time on carbonic anhydrase gene expression in the blastoderm of the Japanese quail (Coturnix c. japonica)

, 2008
(1) The gene expression of carbonic anhydrase, a key enzyme for the production sub-embryonic fluid (SEF), was assessed in turned and unturned eggs of the Japanese quail.
Baggott, G. K., Baggott, Glenn K., Sugden, D, Sugden, D., de Winter, Patricia, De Winter, P.   +5 more
core   +1 more source

Chapter 14 - β-Carbonic Anhydrases: General Features and Medical Implications

, 2015
The β-carbonic anhydrases are a structurally unique class of carbonic anhydrases that is found in a diverse array of microorganisms, algae, plants, and invertebrates.
Roger S. Rowlett, Margaret M. Suhanovsky, Rowlett, Roger S., Kelly Sheppard, Suhanovsky, Margaret M., Sheppard, Kelly   +5 more
core   +1 more source