Results 31 to 40 of about 2,925,002 (305)
Structural Basis for the Inhibition of Helicobacter pylori α-Carbonic Anhydrase by Sulfonamides. [PDF]
PLoS ONE, 2015 Periplasmic α-carbonic anhydrase of Helicobacter pylori (HpαCA), an oncogenic bacterium in the human stomach, is essential for its acclimation to low pH. It catalyses the conversion of carbon dioxide to bicarbonate using Zn(II) as the cofactor.
Joyanta K Modak +4 more
doaj +1 more source
International Journal of Molecular Sciences, 2020 Carbonic anhydrases (CAs) exist in all kingdoms of life. They are metalloenzymes, often containing zinc, that catalyze the interconversion of bicarbonate and carbon dioxide—a ubiquitous reaction involved in a variety of cellular processes.
Erik L Jensen, S. Maberly, B. Gontero
semanticscholar +1 more source
The Expression of Carbonic Anhydrases II, IX and XII in Brain Tumors
Cancers, 2020 Carbonic anhydrases (CAs) are zinc-containing metalloenzymes that participate in the regulation of pH homeostasis in addition to many other important physiological functions.
J. Haapasalo +3 more
semanticscholar +1 more source
Carbonic anhydrases in fungi [PDF]
Microbiology, 2010 Carbonic anhydrases (CAs) are metalloenzymes that catalyse the interconversion of carbon dioxide and bicarbonate with high efficiency. This reaction is fundamental to biological processes such as respiration, photosynthesis, pH homeostasis, CO2 transport and electrolyte secretion.
Skander, Elleuche, Stefanie, Pöggeler
openaire +2 more sources
Carbonic Anhydrases: Versatile and Useful Biocatalysts in Chemistry and Biochemistry
Catalysts, 2020 Metalloenzymes such as the carbonic anhydrases (CAs, EC 4.2.1.1) possess highly specialized active sites that promote fast reaction rates and high substrate selectivity for the physiologic reaction that they catalyze, hydration of CO2 to bicarbonate and ...
A. Angeli, F. Carta, C. Supuran
semanticscholar +1 more source
Acipimox inhibits human carbonic anhydrases
Journal of Enzyme Inhibition and Medicinal Chemistry, 2022 Acipimox, a nicotinic acid derivative in clinical use for the treatment of hyperlipidaemia, incorporates a free carboxylic acid and an N-oxide moiety, functionalities known to interact with the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1) and ...
Mattia Mori, Claudiu T. Supuran
doaj +1 more source
Nanomaterials, 2021 Carbonic anhydrases are enzymes capable of transforming carbon dioxide into bicarbonate to maintain functionality of biological systems. Synthetic isolation and implementation of carbonic anhydrases into membrane have recently raised hopes for emerging ...
Qian Liu +4 more
doaj +1 more source
Medical Sciences Forum, 2022 Carbonic anhydrases are metalloenzymes that regulate the interconversion of CO2 and H2CO3, a reaction involved in many physiological processes. A disfunction of these enzymes is known to induce many diseases such as glaucoma, epilepsy and cancer.
Yousra Ouafa Bouone +2 more
doaj +1 more source
Bioinformatic analysis of beta carbonic anhydrase sequences from protozoans and metazoans
Parasites & Vectors, 2014 Background Despite the high prevalence of parasitic infections, and their impact on global health and economy, the number of drugs available to treat them is extremely limited.
Reza Zolfaghari Emameh +4 more
doaj +1 more source
International Journal of Molecular Sciences, 2019 Carbonic anhydrases (CAs) catalyze a reaction fundamental for life: the bidirectional conversion of carbon dioxide (CO2) and water (H2O) into bicarbonate (HCO3−) and protons (H+).
R. Occhipinti, W. Boron
semanticscholar +1 more source