Results 31 to 40 of about 7,272 (219)

Peptide-Gold Nanoparticle Conjugates as Artificial Carbonic Anhydrase Mimics [PDF]

, 2019
We herein describe the design and synthesis of a catalytically active peptide–gold nanoparticle conjugate (Pep-Au-NP) that binds Zn(II) within its peptide monolayer and develops carbonic anhydrase activity. Specifically, a modified variant of the β-sheet
Koksch, Beate, Mikolajczak, Dorian J.
core   +1 more source

Polyamines and α-Carbonic Anhydrases

Molecules, 2016
Natural products represent a straightforward source for molecular structures bearing a vast array of chemical features and potentially useful for biomedical purposes.
Andrea Scozzafava, Claudiu T. Supuran, Fabrizio Carta   +2 more
doaj   +1 more source

The structure of a tetrameric α-carbonic anhydrase fromThermovibrio ammonificansreveals a core formed around intermolecular disulfides that contribute to its thermostability [PDF]

, 2014
Carbonic anhydrase enzymes catalyse the reversible hydration of carbon dioxide to bicarbonate. A thermophilic Thermovibrio ammonificans α-carbonic anhydrase (TaCA) has been expressed in Escherichia coli and structurally and biochemically characterized ...
Berg, Svein, Isupov, Michail N., James, Paul, Kotlar, Hans Kristian, Lioliou, Maria, Littlechild, Jennifer A., Saneei, Vahid, Sayer, Christopher   +7 more
core   +1 more source

Design, synthesis and biological activity of selective hCAs inhibitors based on 2-(benzylsulfinyl)benzoic acid scaffold [PDF]

, 2019
A large library of derivatives based on the scaffold of 2-(benzylsulfinyl)benzoic acid were synthesised and tested as atypical inhibitors against four different isoforms of human carbonic anhydrase (hCA I, II, IX and XII, EC 4.2.1.1).
Akdemir, A., Amoroso, R., Angeli, A., Carradori, S., Cirilli, R., De Filippis, B., De Monte, C., Guglielmi, P., Maccallini, C., Rotondi, G., Secci, D., Supuran, C. T.   +11 more
core   +2 more sources

Coral Carbonic Anhydrases: Regulation by Ocean Acidification

Marine Drugs, 2016
Global change is a major threat to the oceans, as it implies temperature increase and acidification. Ocean acidification (OA) involving decreasing pH and changes in seawater carbonate chemistry challenges the capacity of corals to form their skeletons ...
Didier Zoccola, Alessio Innocenti, Anthony Bertucci, Eric Tambutté, Claudiu T. Supuran, Sylvie Tambutté   +5 more
doaj   +1 more source

Major contribution of the type II beta carbonic anhydrase CanB (Cj0237) to the capnophilic growth phenotype of Campylobacter jejuni [PDF]

, 2016
Campylobacter jejuni, the leading cause of human bacterial gastroenteritis, requires low environmental oxygen and high carbon dioxide for optimum growth, but the molecular basis for the carbon dioxide requirement is unclear. One factor may be inefficient
Alazzam, Alber, Allos, Bolton, Bury-Moné, Capasso, Carta, Covarrubias, Cronk, Cronk, De Simone, Dugar, Eichler, Epps, Fernandez, Ferry, Fraser, Gai, Gaskin, Gibson, Gielda, Guccione, Guilloton, Gundogdu, Hani, Hermans, Hofreuter, Hofreuter, Hofreuter, Innocenti, Jitrapakdee, Kakuda, Kaur, Kelley, Kelly, Kelly, Kendall, Kusian, Lotlikar, Marcus, Menefee, Merlin, Muraoka, Ozensoy Guler, Parkhill, Pinard, Sheppard, Smith, Sokol, St Maurice, Stahl, Stahl, Stähler, Supuran, Supuran, Supuran, Velayudhan, Velayudhan, Vilas, Vliet, Vorwerk, Wilks   +61 more
core   +1 more source

Bottom‐Up Coacervate‐Based Artificial Cells: Integrating Cellular Hallmarks into Complex Life‐Like Systems

Angewandte Chemie, EarlyView.
Current interest in artificial cell research underscores its potential to deepen our understanding of life's fundamental processes. This review highlights advances in bottom‐up coacervate‐based artificial cell engineering via combined integration of cellular hallmarks.
Arjan Hazegh Nikroo, Angshuman Das, Madelief A. M. Verwiel, Jan C. M. van Hest   +3 more
wiley   +2 more sources

Plastid proteome prediction for diatoms and other algae with secondary plastids of the red lineage [PDF]

, 2014
The plastids of ecologically and economically important algae from phyla such as stramenopiles, dinoflagellates and cryptophytes were acquired via a secondary endosymbiosis and are surrounded by three or four membranes.
Allen, Allen, Altschul, Apt, Armbrust, Ast, Baldi, Bendtsen, Blum, Bowler, Brown, Bruckner, Bullmann, Cavalier-Smith, Cock, Crooks, Curtis, Domergue, Emanuelsson, Emanuelsson, Fawcett, Felsner, Gould, Gould, Grigoriev, Grouneva, Gruber, Gruber, Gruber, Gschloessl, Hall, Hempel, Hempel, Horton, Huesgen, Joshi-Deo, Kilian, Kilian, Kitao, Kitao, Kroth, Kroth, Kroth, Lepetit, Liaud, Mernberger, Moog, Nielsen, Nielsen, Patron, Patron, Petersen, Schneider, Siaut, Sommer, Sturm, Tachibana, Tanaka, Terashima, Timmis, Vugrinec, Weber, Yandell   +62 more
core   +2 more sources

Sucrose rinse modulates the salivary behavior of carbonic anhydrase VI and its buffering capacity: a longitudinal study in 4 to 6.5-year-old children [PDF]

PeerJ
Background Carbonic anhydrase VI (CA VI) is crucial in regulating oral pH and predicting susceptibility to dental caries. The hypothesis posits that caries activity may alter the CA VI function, diminishing its capacity to regulate pH effectively and ...
Thayse Rodrigues de Souza, Bruna Raquel Zancope, Emerson Tavares de Sousa, Thais Manzano Parisotto, Marcelo Rocha Marques, Marinês Nobre dos Santos   +5 more
doaj   +2 more sources

Carbonic Anhydrase Inhibitors

Kidney and Blood Pressure Research, 1987
The purpose of the present review is to describe the use of carbonic anhydrase inhibitors in clinical medicine and renal physiology. We first describe the localization of carbonic anhydrase within the kidney and then discuss evidence for its role in renal acidification and NaCl absorption.
P A, Preisig, R D, Toto, R J, Alpern
openaire   +2 more sources