Results 51 to 60 of about 2,925,002 (305)

Overview of carbonic anhydrase families/isoforms

, 2014
Carbonic anhydrases (CAs) are metalloenzymes and exist as five distinct families, the a-, b-, g-, d- and z-CAs, in all organisms from the tree of ...
Capasso C., Supuran C. T.
core   +1 more source

Amine, amino acid and oligopeptide carbonic anhydrase activators

, 2014
Carbonic anhydrases (CAs) are metalloenzymes and exist as five distinct families, the a-, b-, g-, d- and z-CAs, in all organisms from the tree of ...
Capasso C., Supuran C. T., De Simone G.
core   +1 more source

Carbonic anhydrases as disease markers

Expert Opinion on Therapeutic Patents, 2019
Introduction: The physiologic importance of fast CO2/HCO3− interconversion in various tissues requires the presence of carbonic anhydrase (CA, EC 4.2.1.1). Fourteen CA isozymes are present in humans, all of them being used as biomarkers.
Sabina Zamanova, A. Shabana, U. Mondal, M. Ilies   +3 more
semanticscholar   +1 more source

Sucrose rinse modulates the salivary behavior of carbonic anhydrase VI and its buffering capacity: a longitudinal study in 4 to 6.5-year-old children [PDF]

PeerJ
Background Carbonic anhydrase VI (CA VI) is crucial in regulating oral pH and predicting susceptibility to dental caries. The hypothesis posits that caries activity may alter the CA VI function, diminishing its capacity to regulate pH effectively and ...
Thayse Rodrigues de Souza, Bruna Raquel Zancope, Emerson Tavares de Sousa, Thais Manzano Parisotto, Marcelo Rocha Marques, Marinês Nobre dos Santos   +5 more
doaj   +2 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Effects of phosphorylation on the activity, inhibition and stability of carbonic anhydrases [PDF]

, 2023
Carbonic anhydrases (CAs) are a metalloenzyme family that have important roles in cellular processes including pH homeostasis and have been implicated in multiple pathological conditions.1 Small molecule inhibitors have been developed to target carbonic ...
Claudiu, Supuran, Dominic, Glover, William, Donald, Daniel, Winter, Xiaojing, Huang   +4 more
core   +2 more sources

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Should I Stay or Should I Go—Leveraging an Overlooked Feature of Click‐to‐Release Chemistry for Affinity Labeling

Angewandte Chemie, EarlyView.
Click‐to‐release (C2R) chemistry is redirected from payload liberation toward ligand‐directed covalent protein labeling through a transient dihydropyridazine methide (DHP‐methide). This concept opens the way to dual‐functional systems combining covalent target engagement with controlled effector release.
Dóra Kern, Krisztina Németh, Tímea Imre, József Simon, Kitti Meggyes, Gergő Bárdos, László Petri, Márton Bojtár, Attila Kormos, Péter Kele   +9 more
wiley   +2 more sources

Pharmacological inhibition of carbonic anhydrases with a positively charged pyridinium sulfonamide phenocopies the neuroprotective effects of Car9 genetic ablation in a murine setting of oxygen/glucose deprivation followed by re-oxygenation and is associated with improved neuronal function in ischemic rats

Heliyon
Carbonic anhydrases constitute a family of metalloenzymes vital for maintaining acid-base balance and regulating pH in physio-pathological processes. These findings suggest carbonic anhydrases as potential therapeutic targets for treating pH-associated ...
Sara Amiranda, Mariangela Succoio, Serenella Anzilotti, Ornella Cuomo, Tiziana Petrozziello, Valentina Tedeschi, Arianna Finizio, Giorgia Mele, Seppo Parkkila, Lucio Annunziato, Giuseppina De Simone, Giuseppe Pignataro, Agnese Secondo, Nicola Zambrano   +13 more
doaj   +1 more source

Effect of Anti-Carbonic Anhydrase Antibodies on Carbonic Anhydrases I and II [PDF]

Clinical Chemistry, 2003
Carbonic anhydrase (CA; EC 4.2.1.1) is a zinc enzyme that is widely distributed in the living world and is involved in many biochemical processes that depend on the hydration/dehydration of carbon dioxide/bicarbonate [reviewed in Refs. (1)(2)(3)(4)(5)(6)].
BOTRE', Francesco, BOTRE', Claudio, E. Podesta, M. Podda, P. Invernizzi   +4 more
openaire   +3 more sources