Results 71 to 80 of about 2,925,002 (305)

Activation of carbonic anhydrase isoforms involved in modulation of emotional memory and cognitive disorders with histamine agonists, antagonists and derivatives

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
Carbonic anhydrases (CAs, EC 4.2.1.1) activators were shown to be involved in memory enhancement and learning in animal models of cognition. Here we investigated the CA activating effects of a large series of histamine based compounds, including ...
Gustavo Provensi, Alessio Nocentini, Maria Beatrice Passani, Patrizio Blandina, Claudiu T. Supuran   +4 more
doaj   +1 more source

CARBONIC ANHYDRASE IN MOLLUISCS

The Biological Bulletin, 1948
Carbonic anhydrase has been demonstrated in the mantle tissues and body fluids of most of 12 species of pelecypods and 8 species of gastropods.
Freeman, John A, Wilbur, Karl M
openaire   +3 more sources

CA9‐Targeted PET Imaging for Noninvasive Discrimination of Clear Cell Renal Cell Carcinoma and Associated Tumor Biological Features

Advanced Science, EarlyView.
CA9‐targeted PET imaging could be a noninvasive approach to characterize clear cell renal cell carcinoma and associated tumor biology. PET uptake correlates with tumor CA9 expression and is linked to angiogenic activity, immune remodeling, and metabolic reprogramming.
Kailei Chen, Sixuan Cheng, Jian Shi, Ruijie Liu, Yilong Wu, Xin Zheng, Xinlun Song, Yunxuan Zhang, Lei Liu, Zhihao Wei, Qi Wang, Xinwei Li, Zirui Dong, Yuenan Liu, Hongmei Yang, Xiaoli Lan, Chunxia Qin, Dawei Jiang, Keshan Wang, Xiaoping Zhang   +19 more
wiley   +1 more source

β-carbonic anhydrases play a role in salicylic acid perception in Arabidopsis

PLoS ONE, 2017
The plant hormone salicylic acid (SA) is required for defense responses. NON EXPRESSER OF PATHOGENESIS RELATED 1 (NPR1) and NON RECOGNITION OF BTH-4 (NRB4) are required for the response to SA in Arabidopsis (Arabidopsis thaliana).
L. Medina-Puche, M. J. Castelló, J. V. Canet, J. Lamilla, M. Colombo, P. Tornero   +5 more
semanticscholar   +1 more source

Esterase activity of carbonic anhydrases serves as surrogate for selecting antibodies blocking hydratase activity

Journal of Enzyme Inhibition and Medicinal Chemistry, 2015
Carbonic anhydrase 9 (CA9) and carbonic anhydrase 12 (CA12) were proposed as potential targets for cancer therapy more than 20 years ago. However, to date, there are only very few antibodies that have been described to specifically target CA9 and CA12 ...
N. R. Uda, Volker Seibert, F. Stenner-Liewen, P. Müller, P. Herzig, Gabor Gondi, R. Zeidler, M. V. van Dijk, A. Zippelius, C. Renner   +9 more
semanticscholar   +2 more sources

Chromatin Packing Domain Engineering Through the Manipulation of Nuclear Cationic States

Advanced Science, EarlyView.
Manipulation of intranuclear divalent cation concentrations rapidly and reversibly remodels chromatin packing domains in living cells. Magnesium depletion disrupts domain compaction, heterochromatin organization, and transcriptional regulation, whereas magnesium loading promotes more compact and stable domains.
Cody L. Dunton, Carrillo Paola Gonzalez, Luay Almassalha, Wing Shun Li, Ruyi Gong, Nicolas Acosta, I Chae Ye, Jane Frederick, Christopher Hogg, Saira John, J. A. Gareth Williams, Rikkert J. Nap, Igal Szleifer, Vadim Backman   +13 more
wiley   +1 more source

Role of carbonic anhydrases in skin wound healing

Experimental &Molecular Medicine, 2017
Skin wound closure occurs when keratinocytes migrate from the edge of the wound and re-epithelialize the epidermis. Their migration takes place primarily before any vascularization is established, that is, under hypoxia, but relatively little is known ...
Harlan R. Barker, Marleena Aaltonen, Pei-wen Pan, Maria Vähätupa, Pirkka Kaipiainen, U. May, Stuart Prince, Hannele Uusitalo-Järvinen, A. Waheed, S. Pastoreková, W. Sly, S. Parkkila, T. Järvinen   +12 more
semanticscholar   +1 more source

Chapter 14 - β-Carbonic Anhydrases: General Features and Medical Implications

, 2015
The β-carbonic anhydrases are a structurally unique class of carbonic anhydrases that is found in a diverse array of microorganisms, algae, plants, and invertebrates.
Roger S. Rowlett, Margaret M. Suhanovsky, Rowlett, Roger S., Kelly Sheppard, Suhanovsky, Margaret M., Sheppard, Kelly   +5 more
core   +1 more source

A Site‐Aware Representation Learning Framework For Unified Molecular Interaction Modeling and Generative Design

Advanced Science, EarlyView.
MolDBG is a site‐aware, sequence‐only framework that unifies drug‐target affinity prediction, binding‐site identification, and affinity‐conditioned molecular generation for structured proteins. Guided by multi‐task binding‐site supervision, it aligns interaction‐critical residues before learning drug‐target representations and simultaneously infers ...
Gang Luo, Qianqian Zhang, Chenhao Wang, Zhiheng Yi, Alex Jinpeng Wang, Jing Tang, Min Li   +6 more
wiley   +1 more source

Identification of Bicarbonate as a Trigger and Genes Involved with Extracellular DNA Export in Mycobacterial Biofilms

mBio, 2016
Extracellular DNA (eDNA) is an integral biofilm matrix component of numerous pathogens, including nontuberculous mycobacteria (NTM). Cell lysis is the source of eDNA in certain bacteria, but the source of eDNA remains unidentified for NTM, as well as for
Sasha J. Rose, Luiz E. Bermudez
doaj   +1 more source