Results 81 to 90 of about 7,272 (219)

Regulation of pH During Amelogenesis [PDF]

, 2009
During amelogenesis, extracellular matrix proteins interact with growing hydroxyapatite crystals to create one of the most architecturally complex biological tissues.
Rodrigo S. Lacruz, Antonio Nanci, Ira Kurtz, J. Timothy Wright, Michael L. Paine, CE Smith, JD Bartlett, ML Paine, JD Bartlett, S Sasaki, T Takagi, W Sui, ML Paine, A Nanci, A Nanci, CE Smith, H Warshawsky, M Goldberg, JC Hu, O Ryu, K Iwasaki, P Moffatt, P Moffatt, D Deutsch, K Josephsen, EJ Reith, EJ Reith, T Sasaki, CE Smith, A Boyde, A Boyde, A Boyde, RS Lacruz, ED Eanes, MU Nylen, DF Travis, M Goldberg, RA Young, JP Simmer, CE Smith, T Aoba, T Aoba, GE Lyman, MD McKee, CE Smith, CE Smith, CE Smith, CT Supuran, WS Sly, S Toyosawa, CE Smith, S Pastorekova, P Pan, K Kondo, AA Dogterom, T Sugimoto, M Kakei, HM Lin, C Supanchart, J Sok, DH Retief, T Odajima, RE Primosch, RE Primosch, JT Wright, JT Wright, FS Collins, TJ Sferra, ML Drumm, JR Riordan, RA Frizzell, ID Mandel, FT Cua, CK Arquitt, BH Koller, JN Snouwaert, CL Kiefer, B Illek, A Pushkin, D Dinour, LR Gawenis, J Inatomi, SD McAlear, N Abuladze, MO Bevensee, CE Kurschat, J Lecanda, JF Medina, LR Gawenis, DM Lyaruu, JW Bawden, RS Lacruz, JT Wright, PJ Crawford, DA Parry, FY Demirci, Z Katzir, HS Koppang, T Igarashi, J Elizabeth, TD Azevedo, MP Whyte   +101 more
core   +3 more sources

Engineered B7‐H3 Binding in Modular Gp2 Miniproteins

Biotechnology and Bioengineering, EarlyView.
ABSTRACT B7‐H3, an important immune checkpoint modulator of T‐cell function, is a tumor vasculature biomarker and is overexpressed in a variety of cancers. Its expression is associated with tumor growth, metastasis, and poor clinical prognosis, which makes B7‐H3 an appealing target for diagnostics and therapeutics.
Abbigael Harthorn, Hannah K. Windsor, Zachary Schmitz, Nathaniel Cheung, Ebube Agwaramgbo, Benjamin J. Hackel   +5 more
wiley   +1 more source

Primary mono- and bis-sulfonamides obtained via regiospecific sulfochlorination of N-arylpyrazoles: inhibition profile against a panel of human carbonic anhydrases

Journal of Enzyme Inhibition and Medicinal Chemistry, 2017
A diverse set of mono- and bis-sulfonamide was obtained via a direct, chemoselective sulfochlorination of readily available yet hitherto unexplored N-arylpyrazole template.
Mikhail Krasavin, Mikhail Korsakov, Oksana Ronzhina, Tiziano Tuccinardi, Stanislav Kalinin, Muhammet Tanç, Claudiu T. Supuran   +6 more
doaj   +1 more source

Beta-carbonic anhydrases play a role in fruiting body development and ascospore germination in the filamentous fungus Sordaria macrospora.

PLoS ONE, 2009
Carbon dioxide (CO(2)) is among the most important gases for all organisms. Its reversible interconversion to bicarbonate (HCO(3) (-)) reaches equilibrium spontaneously, but slowly, and can be accelerated by a ubiquitous group of enzymes called carbonic ...
Skander Elleuche, Stefanie Pöggeler
doaj   +1 more source

Cold atmospheric plasma‐mediated tumor microenvironment remodeling for cancer treatment

BMEMat, EarlyView.
Schematic presentation of CAP‐mediated TME remodeling. This review summarizes recent efforts in cold atmospheric plasma (CAP) application in cancer treatment, highlighting the anticancer potential of CAP, molecular mechanisms, and future perspectives for further improvement and clinical translation.
Israr Khan, Qiujie Fang, Cao Fei, Ziyuan Wang, Zhaowei Chen, Guojun Chen, Zhiming Xu, Shu Xu, Zhitong Chen   +8 more
wiley   +1 more source

Metabolic Effect of Estrogen Receptor Agonists on Breast Cancer Cells in the Presence or Absence of Carbonic Anhydrase Inhibitors

Metabolites, 2016
Metabolic shift is one of the major hallmarks of cancer development. Estrogen receptor (ER) activity has a profound effect on breast cancer cell growth through a number of metabolic changes driven by its effect on transcription of several enzymes ...
Anissa Belkaid, Miroslava Čuperlović-Culf, Mohamed Touaibia, Rodney J. Ouellette, Marc E. Surette   +4 more
doaj   +1 more source

The "Click-tail approach" for the design and synthesis of novel carbonic anhydrase inhibitors [PDF]

, 2013
The Carbonic Anhydrases (CAs) are a family of zinc enzymes deputed to the interconversion of carbonic dioxide to hydrogen carbonate. Herein, we report on a sustainable modular strategy, also called "clicktail approach", used to obtain two series of 4-(4 ...
Carta, Fabrizio, Ihm, Simone, McKenna, Robert, Micheletto, Laura, Pala, Nicolino, Sechi, Mario, Supuran, Claudiu T.   +6 more
core  

Construction of a CO2‐Fixing Compartment Using a Shape‐Transforming DNA Scaffold

Chemistry – A European Journal, EarlyView.
A shape‐transforming DNA scaffold encapsulates RuBisCO within a controllable, self‐contacting compartment that mimics the carboxysome. The scaffold switches between open and closed states, enabling direct comparison of identical enzyme populations in different microenvironments.
Hui Yang, Peng Lin, Surachada Chuaychob, Huyen Dinh, Mei Nakabayashi, Eiji Nakata, Takashi Morii   +6 more
wiley   +1 more source

Carbonic Anhydrases: Role in pH Control and Cancer

Metabolites, 2018
The pH of the tumor microenvironment drives the metastatic phenotype and chemotherapeutic resistance of tumors. Understanding the mechanisms underlying this pH-dependent phenomenon will lead to improved drug delivery and allow the identification of new ...
Mam Y. Mboge, Brian P. Mahon, Robert McKenna, Susan C. Frost   +3 more
doaj   +1 more source

Asymmetric Reduction of Unactivated Alkenes

Chemistry – A European Journal, EarlyView.
Unactivated alkenes rank among the most inert functional groups in synthesis and their selective reduction remains challenging. This Review charts the evolution from classical metal‐catalyzed hydrogenation to radical hydrogen atom transfer (HAT) and emerging biocatalytic concepts, highlighting how complementary mechanistic strategies, including the ...
Nico D. Fessner, Sebastian Roth, Richard Niese, Michael Müller   +3 more
wiley   +1 more source