Results 101 to 110 of about 7,953 (283)

Plasma PlGF as a Potential Biomarker in Ramucirumab‐Based Second‐Line Therapy for Advanced Gastroesophageal Adenocarcinoma: Exploratory Biomarker Analysis from the Phase II Part of the RAMIRIS Trial

International Journal of Cancer, EarlyView.
Antiangiogenic treatment with ramucirumab is a standard second‐line option in advanced gastric and gastroesophageal junction adenocarcinoma. However, reliable biomarkers are currently lacking. This exploratory biomarker analysis of the RAMIRIS trial suggests that elevated baseline and early on‐treatment levels of the pro‐angiogenic placental growth ...
Jurek Hille, Sylvie Lorenzen, Claudia Pauligk, Victoria Gensch, Peter Thuss‐Patience, Eray Goekkurt, Thomas Ettrich, Florian Lordick, Carsten Bokemeyer, Christian Müller, Peter Reichardt, Martin Sökler, Daniel Pink, Stefan Probst, Thorsten O. Goetze, Salah E. Al‐Batran, Sonja Loges, Melanie Janning   +17 more
wiley   +1 more source

Analysis of ligand binding to recombinant human carbonic anhydrases I, II, VII, IX and XIII.

, 2013
Carbonic anhydrases (CAs) are metalloenzymes that catalyze the conversion between carbon dioxide and bicarbonate. Their inhibition can be applied for treatment of different diseases, such as glaucoma, cancer, obesity, epilepsy, osteoporosis, etc.
Baranauskienė, Lina,
core  

α‑Carbonic Anhydrases Possess Thioesterase Activity

, 2015
The α-carbonic anhydrases (CAs, EC 4.2.1.1) show catalytic versatility acting as esterases with carboxylic, sulfonic, and phosphate esters. Here we prove by kinetic, spectroscopic, and MS studies that they also possess thioesterase activity with a ...
Tanc, Muhammet, Carta, Fabrizio, Supuran, Claudiu Trandafir, Andrea Scozzafava (74698), Claudiu T. Supuran (24658), Fabrizio Carta (1330644), Scozzafava, Andrea, Muhammet Tanc (1638982)   +7 more
core   +1 more source

Optimizing feather hydrolysate via machine learning for microbial recycling of waste concrete fines

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND The concrete industry faces significant challenges from CO2 emissions and the disposal of waste concrete fines (WCF). Microbially induced calcite precipitation (MICP) can bind WCF into bioconcrete, but the high cost of commercial culture media hinders its application.
Henrietta Ottová, Barbora Malíková, Václav Nežerka, Petr Holeček, Dana Koňáková, Hana Stiborová   +5 more
wiley   +1 more source

Diagnostic modulation of subgingival proteomic biomarkers by age and smoking habits in periodontitis

Journal of Periodontology, EarlyView.
Abstract Background Although age and smoking influence the periodontal proteome, their impact on subgingival biomarkers for diagnosing periodontitis remains unclear. This multicenter study assessed their influence on subgingival proteins for disease detection.
Triana Blanco‐Pintos, Alba Regueira‐Iglesias, Berta Suárez‐Rodríguez, Alba Sánchez‐Barco, Iryna Kuz, Marta Relvas, Susana Belén Bravo, Carlos Balsa‐Castro, Inmaculada Tomás   +8 more
wiley   +1 more source

Facile synthesis of aminobiphenyl sulfonamides via Chan–Lam coupling and their biological evaluation as potent carbonic anhydrase inhibitors

Scientific Reports
Inhibition of carbonic anhydrases (EC 4.2.1.1, hCAs) is known to be a potential target for treatment of several disorders like epilepsy, glaucoma, obesity, and cancer.
Moniba Sharif, Abid Mahmood, Aqsa Kanwal, Matloob Ahmad, Nasir Rasool, Muhammad Usman Qamar, Mohammed H. AL Mughram, Amira Ali Mohammed Al-Harethi, Tawaf Ali Shah, Imran Ibrahim Shaikh   +9 more
doaj   +1 more source

Catalytically inactive carbonic anhydrase‐related proteins enhance transport of lactate by MCT1

FEBS Open Bio, 2019
Carbonic anhydrases (CA) catalyze the reversible hydration of CO2 to protons and bicarbonate and thereby play a fundamental role in the epithelial acid/base transport mechanisms serving fluid secretion and absorption for whole‐body acid/base regulation ...
Ashok Aspatwar, Martti E. E. Tolvanen, Hans‐Peter Schneider, Holger M. Becker, Susanna Narkilahti, Seppo Parkkila, Joachim W. Deitmer   +6 more
doaj   +1 more source

Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research

Mass Spectrometry Reviews, EarlyView.
Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik, Petr Lapcik, Pavla Bouchalova, Pavel Bouchal   +3 more
wiley   +1 more source

Ion Activation Methods for Top‐Down Proteomics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Mass spectrometry (MS) has emerged as a premier method used to characterize the sequences of proteins. Top‐down proteomics aims to capture the multiple sources of structural diversity reflected in proteins, such as those that arise from alternative RNA splicing events or the addition of post‐translational modifications. Tandem MS (i.e., MS/MS)
Jada N. Walker, Jennifer S. Brodbelt
wiley   +1 more source

A guard cell carbonic anhydrase binds and regulates SLAC1 separate from its catalytic activity

Nature Communications
Stomata of plant leaves open to enable CO2 entry for photosynthesis and close when CO2 in the leaf is elevated. CO2 is thought to promote stomatal closure in part by activating the SLAC1 anion channel at the guard cell plasma membrane.
Lingfeng Xia, Jonas Chaves Alvim, Thanh-Hao Nguyen, Cecile Lefoulon, Fernanda A. L. Silva-Alvim, Zhiyi Yu, Martina Klejchova, Sahar Farami, Sakharam Waghmare, Rucha Karnik, Michael R. Blatt   +10 more
doaj   +1 more source