Results 11 to 20 of about 7,953 (283)
Acipimox inhibits human carbonic anhydrases [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2022 Acipimox, a nicotinic acid derivative in clinical use for the treatment of hyperlipidaemia, incorporates a free carboxylic acid and an N-oxide moiety, functionalities known to interact with the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1) and ...
Mattia Mori, Claudiu T. Supuran
doaj +2 more sources
Coral Carbonic Anhydrases: Regulation by Ocean Acidification
Marine Drugs, 2016 Global change is a major threat to the oceans, as it implies temperature increase and acidification. Ocean acidification (OA) involving decreasing pH and changes in seawater carbonate chemistry challenges the capacity of corals to form their skeletons ...
Didier Zoccola +5 more
doaj +2 more sources
Effects of Phosphorylation on the Activity, Inhibition and Stability of Carbonic Anhydrases. [PDF]
Int J Mol Sci, 2023 Carbonic anhydrases (CAs) are a metalloenzyme family that have important roles in cellular processes including pH homeostasis and have been implicated in multiple pathological conditions.1 Small molecule inhibitors have been developed to target carbonic ...
Huang X +4 more
europepmc +2 more sources
1,2,3-Benzoxathiazine-2,2-dioxides – effective inhibitors of human carbonic anhydrases [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 A series of 1,2,3-benzoxathiazine-2,2-dioxides possessing various substituents in the 5, 7, or 8 position was obtained from corresponding 2-hydroxybenzaldehydes in their reaction with sulfamoyl chloride.
Jekaterina Ivanova +4 more
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Thermostable Carbonic Anhydrases in Biotechnological Applications
International Journal of Molecular Sciences, 2015 Carbonic anhydrases are ubiquitous metallo-enzymes which catalyze the reversible hydration of carbon dioxide in bicarbonate ions and protons. Recent years have seen an increasing interest in the utilization of these enzymes in CO2 capture and storage ...
Anna Di Fiore +2 more
exaly +2 more sources
Inhibition of pathogenic bacterial carbonic anhydrases by monothiocarbamates [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 Carbonic anhydrases (CAs) from the pathogenic bacteria Nesseria gonorrhoeae and vancomycin-resistant enterococci (VRE) have recently been validated as antibacterial drug targets. Here we explored the inhibition of the α-CA from N.
Simone Giovannuzzi +9 more
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Investigation on N-Aryl-2-(4-sulfamoylphenyl)hydrazine-1-carbothioamide as Human Carbonic Anhydrases Inhibitors [PDF]
PharmaceuticalsBackground: Among the 15 human (h) carbonic anhydrase (CA; EC 4.2.1.1) isoforms, hCA IX and XII are particularly important due to their roles in tumor cell growth and survival, identifying them as promising targets for anticancer therapy.
Morteza Abdoli +7 more
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Carbonic anhydrases contribute to mitochondrial function, conidial development, and pathogenicity of Magnaporthe oryzae [PDF]
Applied and Environmental MicrobiologyCarbonic anhydrases (CAs) are metalloenzymes widely present in biological systems, capable of catalyzing the reversible hydration of carbon dioxide (CO₂) to form bicarbonate (HCO3⁻) and protons (H+).
Qingqing Cui +10 more
doaj +2 more sources
Carbonic anhydrases in anthozoan corals—A review
Bioorganic and Medicinal Chemistry, 2013 Coral reefs are among the most biologically diverse and economically important ecosystems on the planet. The deposition of massive calcium carbonate skeletons (biomineralization or calcification) by scleractinian corals forms the coral reef framework ...
Anthony Bertucci +2 more
exaly +2 more sources
Multivalent Carbonic Anhydrases Inhibitors [PDF]
International Journal of Molecular Sciences, 2019 Biomolecular recognition using a multivalent strategy has been successfully applied, this last decade on several biological targets, especially carbohydrate-processing enzymes, proteases, and phosphorylases.
Winum, Jean‐yves +8 more
core +5 more sources