Results 11 to 20 of about 29,456 (266)

c‐Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis

Hepatology, EarlyView., 2022
In response to genotoxic injury, c‐Rel upregulates ATM‐Chk2‐p53 pathway DNA damage proteins to limiting hepatocarcinogenesis. Abstract Background and Aims Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death. The NF‐κB transcription factor family subunit c‐Rel is typically protumorigenic; however, it has recently been reported as a
Jack Leslie, Jill E. Hunter, Amy Collins, Amelia Rushton, Lauren G. Russell, Erik Ramon‐Gil, Maja Laszczewska, Misti McCain, Marco Y. W. Zaki, Amber Knox, Yixin Seow, Laura Sabater, Daniel Geh, Neil D. Perkins, Helen L. Reeves, Dina Tiniakos, Derek A. Mann, Fiona Oakley   +17 more
wiley   +1 more source

A nationwide assessment of hepatocellular adenoma resection: Indications and pathological discordance

Hepatology Communications, EarlyView., 2022
Abstract Hepatocellular adenomas (HCAs) are benign liver tumors associated with bleeding or malignant transformation. Data on the indication for surgery are scarce. We analyzed indications and outcome of patients operated for HCAs < 50 mm compared to HCAs ≥ 50 mm. Changes in final postoperative diagnosis were assessed.
Martijn P. D. Haring, Arthur K. E. Elfrink, Christiaan A. J. Oudmaijer, Paul C. M. Andel, Alicia Furumaya, Nenke de Jong, Colin J. J. M. Willems, Thijs Huits, Julie M. L. Sijmons, Eric J. T. Belt, Koop Bosscha, Esther C. J. Consten, Mariëlle M. E. Coolsen, Peter van Duijvendijk, Joris I. Erdmann, Paul Gobardhan, Robbert J. de Haas, Tjarda van Heek, Hwai‐Ding Lam, Wouter K. G. Leclercq, Mike S. L. Liem, Hendrik A. Marsman, Gijs A. Patijn, Türkan Terkivatan, Babs M. Zonderhuis, Izaak Quintus Molenaar, Wouter W. te Riele, Jeroen Hagendoorn, Alexander F. M. Schaapherder, Jan N. M. IJzermans, Carlijn I. Buis, Joost M. Klaase, Koert P. de Jong, Vincent E. de Meijer, the Dutch Benign Liver Tumor Group, R. B. Takkenberg, J. Verheij, O. M. van Delden, J. I. Erdmann, B. V. van Rosmalen, A. Furumaya, G. Kazemier, D. Ramsoekh, J. N. M. IJzermans, R. A. de Man, M. D. Doukas, M. G. Thomeer, A. J. Klompenhouwer, A. F. M. Schaapherder, M. E. Tushuizen, M. J. Coenraad, A. S. L. P. Crobach, M. C. Burgmans, S. Feshtali, M. M. E. Coolsen, M. Kramer, J. C. Beckervordersandforth, I. V. Samarska, C. van der Leij, R. Miclea, J. H. W. de Wilt, P. B. van den Boezem, E. T. T. L. Tjwa, I. Munsterman, S. Vos, S. van Koeverden, V. E. de Meijer, F. J. C. Cuperus, R. J. de Haas, E. W. Duiker, M. P. D. Haring   +70 more
wiley   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Phytochemical analysis of Ziziphus jujube leaf at different foliar ages based on widely targeted metabolomics

Open Chemistry, 2022
Based on metabolomics, the metabolites of Jujube leaves LS1 (one bud and two leaves), LS2 (one bud and three leaves), and LS3 (one bud and four leaves) were taken and examined by ultra-high performance liquid chromatography-mass spectrometry technique ...
Liu Hongxia, Wang Lefei, Xu Mingyue, Deng Benliang, Liu Hui, Zhao Xusheng   +5 more
doaj   +1 more source

Human non-CpG methylation patterns display both tissue-specific and inter-individual differences suggestive of underlying function

Epigenetics, 2022
DNA methylation (DNAm) in mammals is mostly examined within the context of CpG dinucleotides. Non-CpG DNAm is also widespread across the human genome, but the functional relevance, tissue-specific disposition, and inter-individual variability has not ...
Philip Titcombe, Robert Murray, Matthew Hewitt, Elie Antoun, Cyrus Cooper, Hazel M Inskip, Joanna D Holbrook, Keith M Godfrey, Karen Lillycrop, Mark Hanson, Sheila J Barton   +10 more
doaj   +1 more source

Tackling NHSN Location Mapping in a Large Healthcare System Utilizing a Robust Decision Support Tool

Antimicrobial Stewardship & Healthcare Epidemiology
Background: Hospitals experienced increased demand for acute care and specialty services during recovery following COVID-19 epidemics. Internal analysis identified potential inaccuracies in NHSN location unit designations across a large healthcare system
Julia Moody, Rachel Long, Keetha Kratzer, Maribeth Coluni, Melissa Gallant, Danna Harmon   +5 more
doaj   +1 more source

Application of chemometric analysis using physicochemical and chromatographic data to differentiate the origin of plant protection products containing trinexapac-ethyl [PDF]

Journal of Plant Protection Research
The European market for plant protection products (PPPs) faces significant challenges related to counterfeit and substandard PPPs, posing threats to sustainable agriculture and food safety. This study explored the application of chemometric methods based
Patrycja Marczewska, Joanna Rolnik, Tomasz Stobiecki   +2 more
doaj   +1 more source

Who needs and continues to need paediatric palliative care? An evaluation of utility and feasibility of the Paediatric Palliative Screening scale (PaPaS)

BMC Palliative Care, 2020
Background While the populations of children who can benefit from paediatric palliative care (PPC) have been broadly defined, identifying individual patients to receive PPC has been problematic in practice.
Poh Heng Chong, Janice Soo, Zhi Zheng Yeo, Raymond Qishun Ang, Celene Ting   +4 more
doaj   +1 more source

A case of monoclonal gammopathy of undetermined significance and minimal change disease complicated by bilateral pulmonary emboli

SAGE Open Medical Case Reports, 2022
Nephrotic syndrome and monoclonal gammopathy of undetermined significance are thought to be associated with venous thromboembolism. However, the association is thought to be weak and is often ignored by clinicians.
Thanuja Neerukonda, Alexandra Witt, Arsen Tan, Bilal Farooqi, Yasna Chaudhary, Christina Kovacs, Luis Silva   +6 more
doaj   +1 more source

Focal Nodular Hyperplasia and Hepatocellular Adenoma: Key Imaging Features and Clinical Relevance

Journal of the Belgian Society of Radiology
Benign hepatocellular lesions are frequent findings in abdominal imaging, with focal nodular hyperplasia (FNH) and hepatocellular adenoma (HCA) being the two principal entities.
Frederik Vandenbroucke
doaj   +1 more source