Results 81 to 90 of about 305,562 (334)

Intratumor heterogeneity in HCC

Aging, 2015
Hepatocellular carcinoma (HCC) is the second most common cause of cancer-related death worldwide [1], generally arising on the background of chronic liver diseases such as chronic viral hepatitis, alcohol-induced liver injury, or fatty liver disease. So far, classification proposals for HCC based on molecular markers are not yet routinely applied in ...
Friemel, Juliane, Frick, Lukas, Weber, Achim   +2 more
openaire   +4 more sources

S···O Conformation Locks Synergistic Alkoxy Chain Engineering of NIR‐II Phototheranostic Molecules for Precision Hepatocellular Carcinoma Theranostics

Advanced Science, EarlyView.
This study introduces a synergistic S‐O conformation locking and alkoxy chain engineering strategy to enhance S‐D‐A‐D‐S molecular planarity. The engineered IR‐BTOG achieves concurrent NIR‐IIa absorption and NIR‐IIb emission, demonstrating exceptional photothermal efficiency and fluorescence quantum yield.
Gui‐long Wu, Fan Wu, Senyou Tan, Hao Xiao, Qiang Kang, Sanlin Deng, Fen liu, Jinkang Zheng, Chaoqiang Li, Guodong Chen, Qinglai Yang   +10 more
wiley   +1 more source

Prognosis of patients with hepatocellular carcinoma. Validation and ranking of established staging-systems in a large western HCC-cohort. [PDF]

, 2012
HCC is diagnosed in approximately half a million people per year, worldwide. Staging is a more complex issue than in most other cancer entities and, mainly due to unique geographic characteristics of the disease, no universally accepted staging system ...
Göke, Burkhard, Kolligs, Frank T., Lamerz, Rolf, Nagel, Dorothea, Nickel, Thomas, Rentsch, Markus, Sappl, Julia, Stieber, Petra, Straub, Gundula, Winkel, Mark op den, Winkel, Philip op den, Zech, Christoph J.   +11 more
core   +3 more sources

Icaritin Ameliorates Cisplatin‐Induced Mitochondrial Metabolic Dysfunction‐Associated Nephrotoxicity and Synergistically Potentiates Its Antitumor Efficacy

Advanced Science, EarlyView.
In this study, scRNA‐seq and chemoproteomics are integrated to characterize CDDP‐bound proteins at single‐cell resolution in tumor‐bearing mice. Additionally, the research demonstrates that ICA alleviates CDDP‐induced nephrotoxicity while enhancing its chemotherapeutic efficacy.
Piao Luo, Junhui Chen, Yehai An, Kun Meng, Wei Zhou, Wenhui Li, Jing Liu, Wentong Zhao, Weiyi He, Ting Cao, Jingnan Huang, Sha Feng, Shiguang Yang, Hongling Hu, Jiaxian Liao, Hengkai He, Mingjing Hao, Qian Zhang, Jigang Wang, Yue Gao   +19 more
wiley   +1 more source

HCC: What's the score [PDF]

Gut, 2002
Choosing a scoring system for staging hepatocellular carcinoma is a difficult task Primary hepatocellular carcinoma (HCC) is a common neoplasm in East Asia, Africa, and the Mediterranean countries, with an age adjusted incidence rate of up to 20–28 cases per 105 in men.
openaire   +2 more sources

Lactylated SPTAN1 Accelerates Hepatocellular Carcinoma Progression by Promoting NOTCH1/HES1 Activation and Immunosuppression

Advanced Science, EarlyView.
This study identifies SPTAN1‐kla as a novel oncogenic driver in HBV‐driven HCC, linking metabolic, epigenetic, and immune mechanisms. SPTAN1‐kla promotes HCC progression via NOTCH1/HES1 activation and immunosuppression. Findings highlight that targeting SPTAN1‐kla provides a framework for HCC treatment to improve clinical outcomes in HBV infected ...
Zengbin Wang, Dongjie Ye, Linqing Wu, Jiayu Liu, Banglun Pan, Zhu Zhang, Xiaoxia Zhang, Yuxin Yao, Nanhong Tang   +8 more
wiley   +1 more source

Diagnostic imaging for hepatocellular carcinoma [PDF]

, 2019
Hepatocellular carcinoma (HCC) occurs mostly in individuals with cirrhosis, which is why the guidelines of the most important scientific societies indicate that these patients are included in surveillance programs through the repetition of an ultrasound ...
DE SANTIS, Adriano
core   +1 more source

METTL1‐Mediated M7G tRNA Modification Promotes Residual Liver Regeneration After Hepatectomy via Translational Control

Advanced Science, EarlyView.
METTL1 and its mediated m7G tRNA modification are significantly up‐regulated after partial hepatectomy (PHx). Overexpression of METTL1 improves the efficiency of liver regeneration after PHx, increases the proliferation of hepatocytes, and accelerates the recovery of liver function.
Manling Huang, Shuirong Lin, Yutong Zhao, Jiale Chen, Linyuan Huang, Yuyao Liu, Zixin Huang, Dongxin An, Yifan Zhang, Zimin Song, Xi Yu, Yunpeng Hua, Jing Wang, Weiwei Wang, Yu Guo, Ming Kuang, Fang Wang, Shuibin Lin, Shunli Shen   +18 more
wiley   +1 more source

Cytotoxic Chemotherapy as an Alternative for Systemic Treatment of Advanced Hepatocellular Carcinoma in Developing Countries

Cancer Management and Research, 2020
Khaled Abouelezz,1 Dipen Khanapara,1 Gaber El-Saber Batiha,2 Esraa A Ahmed,3,4 Helal F Hetta1,5 1Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA; 2Department of Pharmacology and Therapeutics, Faculty of ...
Abouelezz K, Khanapara D, Batiha GES, Ahmed EA, Hetta HF   +4 more
doaj  

The Evolution, Expansion and Evaluation of the Family Economic Security Program [PDF]

, 2016
In 2008, the Fund for Women & Girls of Fairfield County's Community Foundation created the Family Economic Security Program (FESP). The goal of the program is to assist low- and moderate-income working students – particularly women who are single parents

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