Results 61 to 70 of about 219,068 (308)

Expression of Mina53 and CBX8 in Hepatocellular Carcinoma and Their Correlation with Clinicopathological Features and Prognosis

Zhongliu Fangzhi Yanjiu, 2020
Objective To investigate the expressions of Mina53 and CBX8 in hepatocellular carcinoma (HCC), and to analyze their correlation with the clinicopathological features and prognosis of HCC patients.
YE Dongxue, LIU Fen, YANG Qian, FU Haiyang, ZHOU Xuan, XIANG Fenggang   +5 more
doaj   +1 more source

Macrophages as a source of fibrosis biomarkers for non-alcoholic fatty liver disease

Immunological Medicine, 2021
Non-alcoholic fatty liver disease/steatohepatitis (NAFLD/NASH) are becoming major liver diseases worldwide. Liver fibrosis and cirrhosis are among the most significant risk factors of hepatocellular carcinoma (HCC) and associated with the long-term ...
Sachiyo Yoshio, Tatsuya Kanto
doaj   +1 more source

Combating VEGFA‐siRNA‐Induced Metabolic Reprogramming via Glucose Utilization Deprivation

Advanced Science, EarlyView.
An ionizable lipid nanoparticle co‐delivers VEGFA siRNA and glucose oxidase to tumors to counteract VEGFA knockdown‐induced, glutamine‐driven metabolic compensation. Enzymatic glucose consumption reverses the adaptive pathways and restores metabolism toward baseline, thereby sensitizing tumors to therapy.
Lulu Zheng, Shuai Guo, Yingjixing Luo, Pengfei Wu, Haiyin Yang, Yingqiu Xie, Yuchuan Fan, Qing Liu, Bo Hu, Jia Huang, Yuanyu Huang   +10 more
wiley   +1 more source

Monocytes/Macrophages promote vascular CXCR4 expression via the ERK pathway in hepatocellular carcinoma

OncoImmunology, 2018
We recently identified CXCR4 as a novel vascular marker for vessel sprouting in hepatocellular carcinoma (HCC) tissues. Thus, CXCR4+ endothelial cells (ECs) could serve as a potential predictor for patients who may benefit from sorafenib treatment ...
Ya-Ming Meng, Jing Liang, Chong Wu, Jing Xu, Dan-Ni Zeng, Xing-Juan Yu, Huiheng Ning, Li Xu, Limin Zheng   +8 more
doaj   +1 more source

NUP85 Mediates Endoplasmic Reticulum Stress through the USP47/ASK1 Signaling Pathway to Regulate the Progression of Liver Fibrosis

Advanced Science, EarlyView.
In the present study, we have demonstrated that the NUP85‐USP47‐ASK1 signaling pathway may have regulated the progression of liver fibrosis through modulating ERS. Additionally, we have developed a CREKA‐coupled liposome to target delivery of MV, a pharmacological inhibitor of NUP85, to activated HSCs, thereby attenuating liver fibrosis. ABSTRACT Liver
Dashuai Yang, Haoran Yang, Linxin Pan, Chang Tian, Fucheng Zuo, Shilei Huang, Xianrui Li, Ming Chen, Cheng Qian, Jie Wang, Zhaolin Chen, Tao Xu   +11 more
wiley   +1 more source

Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

Advanced Science, EarlyView.
ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei, Chunning Li, Lei Zhan, Xiaoyan Li, Yan Hui, Yue Jin, Jing Zhang, Lu Yang, Xin Sun, Xiaoxi Li, Qian Dong, Jingdong Zhang   +11 more
wiley   +1 more source

CENPO is Associated with Immune Cell Infiltration and is a Potential Diagnostic and Prognostic Marker for Hepatocellular Carcinoma

International Journal of General Medicine, 2022
Kun He,1 Mengyi Xie,1 Jingdong Li,1 Yi He,2 Yaolin Yin2 1Institute of Hepato-Biliary-Pancreatic-Intestinal disease, North Sichuan Medical College, Nanchong, People’s Republic of China; 2Department of Hepatobiliary Surgery, Affiliated Hospital of North ...
He K, Xie M, Li J, He Y, Yin Y
doaj  

HCC-specific pathways relative to up-regulated miRNAs.

HCC-specific pathways relative to up-regulated miRNAs.
Kayleigh Smith (17816667), Roger Silva (18404803), Gyorffy Balazs (18404806), Dan Beach (18404800), Francesca Salani (420546), Francesco Crea (1887346)   +5 more
core   +1 more source

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

HCC-specific pathways relative to down-regulated miRNAs.

HCC-specific pathways relative to down-regulated miRNAs.
Kayleigh Smith (17816667), Roger Silva (18404803), Gyorffy Balazs (18404806), Dan Beach (18404800), Francesca Salani (420546), Francesco Crea (1887346)   +5 more
core   +1 more source