Results 41 to 50 of about 219,068 (308)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

A PDCD1 Role in the Genetic Predisposition to NAFLD-HCC? [PDF]

, 2021
Obesity and non-alcoholic fatty liver disease (NAFLD) are contributing to the global rise in deaths from hepatocellular carcinoma (HCC). The pathogenesis of NAFLD-HCC is not well understood. The severity of hepatic steatosis, steatohepatitis and fibrosis
Burt, Alastair D, Yang Lin Liu, Misti Vanette McCain, João P. Maurício, Ruchi Shukla, Marco Y. W. Zaki, Ann K. Daly, Fawzy, Michael Atef, Moustafa Fathy, Quentin M. Anstee, Nardeen Eldafashi, Burt, Alastair D., Cristiana Bianco, Cordell, Heather J, Darlay, Rebecca, McCain, Misti Vanette, Shukla, Ruchi, Daly, Ann K, Fathy, Moustafa, Bianco, Cristiana, Rebecca Darlay, Jean-François Dufour, Anstee, Quentin M, Reeves, Helen L, Anstee, Quentin M., Helen L. Reeves, Zaki, Marco Y. W., Dufour, Jean-François, Heather J. Cordell, Haugk, Beate, Maurício, João P, Michael Atef Fawzy, Zaki, Marco Y W, Daly, Ann K., Alastair D. Burt, Maurício, João P., Beate Haugk, Liu, Yang Lin, Reeves, Helen L., Watson, Robyn, Valenti, Luca, Luca Valenti, McStraw, Nikki, Eldafashi, Nardeen, Cordell, Heather J., Robyn Watson, Nikki McStraw   +46 more
core   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Importancia del anestesiólogo en la prevención del dolor crónico [PDF]

Revista Chilena de Anestesia, 2021
Marcos Bolívar, Marcos Bolívar (Jr), María Seijas, Martín Toro, Amalia Bolívar   +4 more
doaj   +1 more source

Layered Nanoporous Platforms for SERS Sensing

Advanced Materials Interfaces, EarlyView.
Here, we present a detailed investigation of the SERS performance of layered nanoporous metals. The controlled deposition of well‐defined, stacked porous layers enabled a systematic analysis of the effects of multimetallic systems in SERS experiments. Numerical models are also used to support the experimental findings.
Yanqiu Zou, Anastasiia Sapunova, Tommaso Giovannini, Chen Wang, Huaizhou Jin, Vincenzo Caligiuri, Sergio Marras, Andrea Schirato, Luca Bursi, Alessandro Alabastri, Shukun Weng, Ali Douaki, German Lanzavecchia, Ivan Marri, Roman Krahne, Nicolò Maccaferri, Zhenrong Zheng, Shangzhong Jin, Denis Garoli   +18 more
wiley   +1 more source

Cancer-cell derived S100A11 promotes macrophage recruitment in ER+ breast cancer

OncoImmunology
Macrophages are pivotal in driving breast tumor development, progression, and resistance to treatment, particularly in estrogen receptor-positive (ER+) tumors, where they infiltrate the tumor microenvironment (TME) influenced by cancer cell-secreted ...
Sanghoon Lee, Youngbin Cho, Yiting Li, Ruxuan Li, Angela Wong Lau, Matthew S. Laird, Daniel Brown, Priscilla McAuliffe, Adrian V. Lee, Steffi Oesterreich, Ioannis K. Zervantonakis, Hatice Ulku Osmanbeyoglu   +11 more
doaj   +1 more source

Co-Administration of iRGD with Sorafenib-Loaded Iron-Based Metal-Organic Framework as a Targeted Ferroptosis Agent for Liver Cancer Therapy

International Journal of Nanomedicine, 2021
Xianchuang Liu,1 Xinyang Zhu,1 Xun Qi,1 Xianwei Meng,2 Ke Xu1 1Department of Radiology and Key Laboratory of Diagnostic Imaging and Interventional Radiology of Liaoning Province, The First Affiliated Hospital of China Medical University, Shenyang ...
Liu X, Zhu X, Qi X, Meng X, Xu K
doaj  

Reversion of tumor hepatocytes to normal hepatocytes during liver tumor regression in an oncogene-expressing transgenic zebrafish model

Disease Models & Mechanisms, 2019
Tumors are frequently dependent on primary oncogenes to maintain their malignant properties (known as ‘oncogene addiction’). We have previously established several inducible hepatocellular carcinoma (HCC) models in zebrafish by transgenic expression of ...
Yan Li, Ira Agrawal, Zhiyuan Gong
doaj   +1 more source

Fibrates Inhibit PLTP‐induced M2 Macrophage Infiltration and Increase the Sensitivity of Hepatocellular Carcinoma to ICIs

Advanced Science, EarlyView.
Phospholipid transfer protein(PLTP) plays a critical role in forming a complex with kinase A (AURKA) and P65. This interaction facilitates phosphorylation of P65 at Ser536, leading to the activation of the NF‐κB signaling pathway. Ultimately, this leads to the upregulation of downstream cytokines, including IL‐6, IL‐8, and CSF‐1, which promotes M2 ...
Xinyue Liang, Yaning Li, Jianxun Cai, Lisi Luo, Pengfei Yang, Yutong Chen, Jiancong Zhou, Yan Zeng, Jiaping Yu, Weiyu Zhang, Wenzheng Pang, Yufang Li, Chunhua Wen, Jian Li, Linjuan Zeng   +14 more
wiley   +1 more source