Results 31 to 40 of about 219,068 (308)

Anti-angiogenesis in hepatocellular carcinoma treatment : current evidence and future perspectives

, 2011
Hepatocellular carcinoma (HCC) is among the most common cancer diseases worldwide. Arterial hypervascularisation is an essential step for HCC tumorigenesis and can be targeted by transarterial chemoembolization (TACE).
Trojan, Jörg, Welker, Martin-Walter
core   +1 more source

Functional microRNA high throughput screening reveals miR-9 as a central regulator of liver oncogenesis by affecting the PPARA-CDH1 pathway [PDF]

, 2015
Background: Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths, reflecting the aggressiveness of this type of cancer and the absence of effective therapeutic regimens.
Drakaki, A, Dimitrios Iliopoulos, Drakaki, Alexandra, Maria Hatziapostolou, Iliopoulos, Dimitrios, Georgoulias, V, Vassilis Georgoulias, Hatziapostolou, M, Alexandra Drakaki, Christos Polytarchou, Vorvis, Christina, Polytarchou, Christos, John Souglakos, Georgoulias, Vassilis, Poultsides, George A, Poultsides, GA, Iliopoulos, D, Hatziapostolou, Maria, George A. Poultsides, Souglakos, J, Vorvis, C, Souglakos, John, Christina Vorvis, Polytarchou, C   +23 more
core   +1 more source

Hepatitis B viral load and risk for liver cirrhosis and hepatocellular carcinoma in The Gambia, West Africa. [PDF]

, 2010
The main objectives of this study were to define the occurrence and levels of hepatitis B virus (HBV) DNA in asymptomatic HBV carriers, cirrhosis patients and hepatocellular carcinoma (HCC) cases from The Gambia, and to evaluate the risk for cirrhosis or
Whittle, H, T. Welzel, S. Rowland-Jones, Kuniholm, MH, P. Hainaut, G. D. Kirk, McConkey, S, A. J. Hall, Mendy, ME, Kaye, S, S. Kaye, M. H. Kuniholm, Kirk, GD, Hainaut, P, J. J. Goedert, M. E. Mendy, Welzel, T, Hall, AJ, S. McConkey, O. A. Lesi, H. Whittle, Goedert, JJ, Rowland-Jones, S, Lesi, OA   +23 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, Volume 20, Issue 6, Page 1591-1611, June 2026.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

From Gretel to Strudelcity: Empowering Teachers Regarding Generative AI for Enhanced AI Literacy with CollectiveGPT

Education Sciences
In the era of transformative technologies, generative artificial intelligence (genAI) offers profound opportunities and challenges for education. This study explores the development and execution of an interactive workshop designed to equip educators ...
Benedikt Brünner, Sandra Schön, Martin Ebner   +2 more
doaj   +1 more source

Actual therapeutic efficacy of pre-transplant treatment on hepatocellular carcinoma and its impact on survival after salvage living donor liver transplantation. [PDF]

, 2009
BACKGROUND: The exact efficacy of pre-liver transplant (LT) therapy for hepatocellular carcinoma (HCC) and the impact on survival after LT remain controversial in regard to salvage LT.
Hidaka, Masaaki, Takatsuki, Mitsuhisa, Tomonaga, Tetsuo, Okudaira, Sadayuki, Yamanouchi, Kosho, Ichikawa, Tatsuki, Tajima, Yoshitsugu, Miyazaki, Kensuke, Miyaaki, Hisamitsu, Inokuma, Takamitsu, Kanematsu, Takashi, Eguchi, Susumu   +11 more
core   +1 more source

Mst Out and HCC In [PDF]

Cancer Cell, 2009
Mst1 and Mst2 are key components of the Hippo tumor suppressor pathway. In this issue, Zhou et al. (2009) reported that Mst1/2 ablation leads to hepatocellular carcinomas. Unexpectedly, Mst1/2 may activate another kinase besides Lats1 and Lats2 to phosphorylate YAP, and the role of Mst1/2 in YAP regulation is cell type dependent.
Zhao, Bin, Lei, Qunying, Guan, Kun-Liang
openaire   +2 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, Volume 20, Issue 6, Page 1494-1512, June 2026.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Maturity Assessment for Integrated Care during Health Transformation Using SCIROCCO Tool

The International Journal of Frontier Sciences
Integrated health care has the ability to provide adequate care system in different modalities of medical care. Saudi Arabia is going through major transformation in its health care services in order to provide sufficient resources.
Khalid I. Alqumaizi, Manal Aledaili, Khalid M. Aladaili, Ibrahim Z. Bin-Hussain, Sami A. Alshammari, Shahad A. Alqahtani   +5 more
doaj   +1 more source

EFFECT OF GROUNDWATER SALINITY LEVEL ON SOIL USING REMOTE SENSING AND GIS TECHNIQUES: CASE STUDY OF SOUTHWEST OF BASRA PROVINCE [PDF]

Journal of Engineering Science and Technology, 2018
Groundwater salinity level is one of the most important considerations for monitoring soil degradation that threat some regions in the southwest of Basra Province, Iraq. The aim of this research is to assign the appropriate and effective image processing
MUSHTAK T. JABBAR, AMMAR S. DAWOOD, HAYFAA J. AL-TAMEEMI   +2 more
doaj