Results 81 to 90 of about 236,151 (302)

WED-346 Single-cell profiling reveals altered natural killer cell composition and transcriptional programs in MASLD-related HCC

Background and aims: Liver cancer is a leading cause of cancer death, and its incidence is expected to rise over the next 20 years. Hepatocellular carcinoma (HCC), comprising 85–90% of primary liver cancers, has a poor prognosis.
Team, HCC Multidisciplinary, Tebaldi, Toma, Mondelli, Mario Umberto, Oliviero, Barbara, Maestri, Marcello, Corallo, Salvatore, La Gaipa, Alessia, Busarello, Emma, Mantovani, Stefania   +8 more
core   +1 more source

Single‐Dose TACE‐Like Injection of Sustained‐Release Panobinostat/IL‐12 Polymeric Microparticles is Effective in Preclinical Liver Cancer Models

Advanced Science, EarlyView.
A novel PLGA/PBAE polymer microparticle platform revolutionizes intermediate‐stage liver cancer treatment by co‐delivering panobinostat and IL‐12 via a single TACE‐like injection. This sustained‐release system overcomes tumor immunosuppression, triggers robust innate and adaptive immune responses, and establishes tertiary lymphoid structures ...
Hongzhe Yu, Ling Li, Sachin S. Surwase, Xin Ming M. Zhou, Hongtao Qian, Joel C. Sunshine, Florin M. Selaru, Jordan J. Green   +7 more
wiley   +1 more source

HCC: What's the score [PDF]

Gut, 2002
Choosing a scoring system for staging hepatocellular carcinoma is a difficult task Primary hepatocellular carcinoma (HCC) is a common neoplasm in East Asia, Africa, and the Mediterranean countries, with an age adjusted incidence rate of up to 20–28 cases per 105 in men.
openaire   +2 more sources

HCC-specific pathways relative to up-regulated miRNAs.

HCC-specific pathways relative to up-regulated miRNAs.
Kayleigh Smith (17816667), Roger Silva (18404803), Gyorffy Balazs (18404806), Dan Beach (18404800), Francesca Salani (420546), Francesco Crea (1887346)   +5 more
core   +1 more source

Defect‐Engineered BiO2‐X Nanosheets Mediate Sono‐Thermomechanical ECM Remodeling for Hepatocellular Carcinoma Immunotherapy

Advanced Science, EarlyView.
Herein, an ultrasound‐responsive BiO2‐X/siFn1 nanoplatform is developed to overcome anti‐PD‐1 resistance in hepatocellular carcinoma. Upon ultrasound irradiation, the platform downregulates fibronectin expression, while its sonothermal effect softens the dense extracellular matrix and activates antitumor immunity in the tumor microenvironment, thereby ...
Huimin Tian, Shen Zhang, Bolin Wu, Yichi Chen, Haitao Shang, Haoyan Tan, Chunyue Wang, Weichen Xu, Huixiong Xu, Haohao Yin, Wen Cheng   +10 more
wiley   +1 more source

HCC- and pan-cancer driver genes among miRNA target genes.

HCC- and pan-cancer driver genes among miRNA target genes.
Kayleigh Smith (17816667), Roger Silva (18404803), Gyorffy Balazs (18404806), Dan Beach (18404800), Francesca Salani (420546), Francesco Crea (1887346)   +5 more
core   +1 more source

Autophagy Orchestrates Anti‐Tumor Immunity to Enhance Chemosensitivity via the FBXW2/C/EBPβ/TIMP‐2 Axis in Colorectal Cancer

Advanced Science, EarlyView.
Chemotherapy leverages tumor‐cell autophagy to reshape the colorectal cancer immune microenvironment. Autophagy degrades FBXW2 to promote C/EBPβ‐mediated TIMP‐2 transcription and MMP‐9 suppression, driving intra‐tumoral CD8+ T‐cell infiltration. Targeting MMP‐2/9 or restoring TIMP‐2 overcomes chemo‐resistance in autophagy‐deficient tumors. ABSTRACT The
Bing Cheng, Chaoying Wei, Zhitong Niu, Jinxin Chen, Guojie Long, Yingzhen Weng, Qiufeng Liu, Yue Jiang, Panpan Wang, Ronghua Zhang, Qiang Yu, Xiaojian Wu, Wenyu Wang   +12 more
wiley   +1 more source

Synergistic Interactions between Sorafenib and Bortezomib in Hepatocellular Carcinoma Involve Pp2a-Dependent Akt Inactivation

, 2011
Background & Aims: Previously we reported that Akt inactivation determines the sensitivity of hepatocellular carcinoma (HCC) cells to bortezomib. Here we report that combined treatment with sorafenib and bortezomib shows synergistic effects in HCC ...
CHEN, KUEN-FENG;LEE, SHOEI-SHENG;CHEN, PEI-JER;CHENG, ANN-LII, 陳昆鋒;李水盛;陳培哲;鄭安理   +1 more
core   +1 more source

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, EarlyView.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

Role of transarterial chemoembolization as neoadjuvant treatment in T2 stage patients waiting for liver transplantation [PDF]

, 2012
RIASSUNTO Scopo: Valutare retrospettivamente i risultati clinici a lungo termine di pazienti cirrotici con HCC allo stadio T2 sottoposti a trapianto ortotopico di fegato (TOF) dopo chemioembolizzazione intraarteriosa (TACE), rispetto ai risultati ...
BARATTINI, MATTEO
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