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Reproductive Sciences, 2013 Human chorionic gonadotropin (hCG) is produced by trophoblast cells throughout pregnancy, and gene expression studies have indicated that hCG-beta subunit (hCGβ) expression is active at the 2 blastomere stage.
Stephen A Butler, M Freire, Ray K Iles
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Immunochemical Mapping Of Hcg and Hcg-Related Molecules
Scandinavian Journal of Clinical and Laboratory Investigation, 1993The general observations and experiences of three laboratory groups that have studied the immunochemistry of hCG are summarized. A basic model of the types of antibodies which are most frequently observed has been constructed using the information gathered.
J M, Bidart +3 more
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Secretion of hCG-α subunit and hCG by HeLa strains
Nature, 1977IN recent letters1,2, we have independently reported seemingly different secretion patterns of human chorionic gonadotropin (hCG) and its alpha (hCG-α) and beta (hCG-β) subunits by certain HeLa strains. These letters were further discussed in an article in News and Views3.
J M, Lieblich +4 more
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Treatment of Asthenozoospermia with HCG
Andrologia, 200930 patients with isolated asthenozoospermia received a treatment with 5000 I.U. Human-Chorionic-Gonadotropin (HCG) a week intramuscularly for twelve weeks. Pretreatment basal levels of FSH, LH and testosterone were in normal or low normal range. 16 males responded to therapy, the total motility of spermatozoa increased significantly from 34% to 40%. In
H H, Pusch, P, Pürstner, J, Haas
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Human Reproduction, 1994
The possibility of using the immune system to provide protection against an unwanted pregnancy has been postulated since the very early days of modern immunology. During the past two decades or more, a major goal-directed research effort, involving several independent groups of investigators, has been underway with the objective of developing birth ...
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The possibility of using the immune system to provide protection against an unwanted pregnancy has been postulated since the very early days of modern immunology. During the past two decades or more, a major goal-directed research effort, involving several independent groups of investigators, has been underway with the objective of developing birth ...
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Clinical Obstetrics & Gynecology, 2012
Ectopic pregnancies remain an important cause of morbidity and mortality in women of reproductive age. Management of these pregnancies has changed dramatically over the years. Human chorionic gonadotropin (hCG) is a glycoprotein hormone composed of 2 dissimilar subunits, alpha and beta, joined non-covalently.
Kevin, Visconti, Nikki, Zite
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Ectopic pregnancies remain an important cause of morbidity and mortality in women of reproductive age. Management of these pregnancies has changed dramatically over the years. Human chorionic gonadotropin (hCG) is a glycoprotein hormone composed of 2 dissimilar subunits, alpha and beta, joined non-covalently.
Kevin, Visconti, Nikki, Zite
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The Journal of Clinical Endocrinology & Metabolism, 1969
ABSTRACT The metabolic clearance rate (MCR) of human chorionic gonadotropin (HCG) was determined in normal male and female subjects following the intravenous and intramuscular administration of 10,000 IU of HCG. The mean MCR (I/day) in the iv experiments was 3.38 for men and 3.86 for women.
T, Rizkallah +2 more
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ABSTRACT The metabolic clearance rate (MCR) of human chorionic gonadotropin (HCG) was determined in normal male and female subjects following the intravenous and intramuscular administration of 10,000 IU of HCG. The mean MCR (I/day) in the iv experiments was 3.38 for men and 3.86 for women.
T, Rizkallah +2 more
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hCG and hyperglycosylated hCG in the establishment and evolution of hemochorial placentation
Journal of Reproductive Immunology, 2009The evolution of regular chorionic gonadotropin (CG) and hyperglycosylated CG are linked with the evolution of hemochorial placentation in primates. Recent research with humans shows that regular CG promotes spiral artery angiogenesis and hyperglycosylated CG controls invasion by implanting trophoblast cells.
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Effect of Conformation of hCG-β on Generation of hCG-Specific Antibody
Endocrine Research Communications, 1978Most antisera generated to isolated highly purified beta subunits of human glycoprotein hormones are not sufficiently sensitive to detect physiologic blood levels of the native hormone. In the dissociated state, beta subunits assume a conformation different from that in the native hormone.
A C, Lerario +2 more
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Clinical use of HCG and hCG beta determinations.
Scandinavian journal of clinical and laboratory investigation. Supplementum, 1993Recent advances in our understanding of hCG/hCG beta synthesis by trophoblastic and nontrophoblastic tissues together with improved techniques for measuring hCG have helped to define the role of hCG as a clinical marker. HCG determination by sensitive immunometric assay enables detection of hCG immunoreactivity in normal men and women.
K, Mann, B, Saller, R, Hoermann
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