Results 41 to 50 of about 321,381 (359)

HCV-related burden of disease in Europe : a systematic assessment of incidence, prevalence, morbidity, and mortality [PDF]

, 2009
Background Hepatitis C virus (HCV) is a leading cause of chronic liver disease, end-stage cirrhosis, and liver cancer, but little is known about the burden of disease caused by the virus.
Mühlberger, Nikolai, Uwe Siebert, Nikolai Mühlberger, Stefan Zeuzem, Sroczynski, Gaby, Ruth Schwarzer, Siebert, Uwe, Lettmeier, Beate, Schwarzer, Ruth, Gaby Sroczynski, Zeuzem, Stefan, Beate Lettmeier   +11 more
core   +1 more source

Gender as a factor affecting NK cell activity in patients successfully treated for chronic hepatitis C with direct-acting antivirals

Central European Journal of Immunology, 2021
Chronic hepatitis C (CHC) affects the activity of natural killer (NK) cells, but successful interferon- free treatment partially restores it. The goal of this study was to assess whether gender influences NK functionality.
Agata Zientarska, Justyna Mikuła-Pietrasik, Mariusz Kaczmarek, Aleksandra Witkowska, Błażej Rozpłochowski, Arleta Kowala-Piaskowska, Krzysztof Książek, Jan Żeromski, Iwona Mozer-Lisewska   +8 more
doaj   +1 more source

A multi-variant, viral dynamic model of genotype 1 HCV to assess the in vivo evolution of protease-inhibitor resistant variants [PDF]

, 2010
Variants resistant to compounds specifically targeting HCV are observed in clinical trials. A multi-variant viral dynamic model was developed to quantify the evolution and in vivo fitness of variants in subjects dosed with monotherapy of an HCV protease ...
Stefan Zeuzem, Randle, John C. R., Randle John C. R., Lin, Chao, Kwong Ann D., Bambang S Adiwijaya, John C. R. Randle, Sarrazin, Christoph, Paul R. Caron, Herrmann Eva, Zeuzem Stefan, Christoph Sarrazin, Garg Varun, Kieffer, Tara, Brian Hare, Hare, Brian, Varun Garg, Lin Chao, Kieffer Tara, Herrmann, Eva, Caron, Paul R., Kwong, Ann D., Tara Kieffer, Ann D Kwong, Sarrazin Christoph, Chao Lin, Bambang S. Adiwijaya, Adiwijaya, Bambang S., Hare Brian, Paul R Caron, Caron Paul R., Garg, Varun, Eva Herrmann, Ann D. Kwong, John C R Randle, Adiwijaya Bambang S., Zeuzem, Stefan   +36 more
core   +1 more source

Antiviral therapy of chronic hepatitis C: 30 years success story [PDF]

Терапевтический архив, 2019
Exactly 30 years ago, hepatitis C virus was identified. Over the years, tremendous success has been achieved in the treatment of hepatitis C, which is currently considered to be an almost completely curable disease. The review presents the main stages in
D T Abdurakhmanov, T P Rozina, E N Nikulkina, E Z Burnevich, E L Tanashuk, M V Severov, A L Filatova, S Yu Milovanova, V V Karpov, S V Moiseev   +9 more
doaj   +1 more source

Mitochondrial stress in advanced fibrosis and cirrhosis associated with chronic hepatitis B, chronic hepatitis C, or nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Adaptive mitochondrial mechanisms allow mitochondrial resilience and prevent the worsening of fibrosis, while deregulation of these mechanisms promotes the progression from no/minimal‐mild (F0‐F2) fibrosis to advanced fibrosis and cirrhosis (F3‐F4). Abstract Background and Aims Hepatitis B virus (HBV) infection causes oxidative stress (OS) and alters ...
Dimitri Loureiro, Issam Tout, Stéphanie Narguet, Cheikh Mohamed Bed, Morgane Roinard, Ahmad Sleiman, Nathalie Boyer, Nathalie Pons‐Kerjean, Corinne Castelnau, Nathalie Giuly, Dorothy Tonui, Vassili Soumelis, Jamel El Benna, Patrick Soussan, Richard Moreau, Valérie Paradis, Abdellah Mansouri, Tarik Asselah   +17 more
wiley   +1 more source

Attacking the public health crisis of hepatocellular carcinoma at its roots

Hepatology, EarlyView., 2022
Abstract As the third most common cause of cancer‐related death worldwide with significant mortality rates in the United States, hepatocellular carcinoma has strong association with cirrhosis and chronic hepatitis B virus (HBV) with a growing at‐risk population from the rise in chronic liver disease from alcohol use and nonalcoholic fatty liver disease.
Hannah M. Lee, Steven D. Lidofsky, Tamar H. Taddei, Lisa J. Townshend‐Bulson   +3 more
wiley   +1 more source

OE-Abiodun/HIV-HCV-COINFECTION-SIM-CODE: HIV-HCV Co-infection [PDF]

, 2022
MAPLE SIMULATION CODE FOR HIV-HCV MODEL.zip Full Changelog: https://github.com/OE-Abiodun/HIV-HCV-COINFECTION-SIM-CODE/commits/v3.0.
Oluwakemi Elizabeth Abiodun
core   +1 more source

Association Between DEPDC5 and PNPLA3 Variants and the Risk of Hepatocellular Carcinoma in HCV-Infected Patients in Egypt [PDF]

Journal of Bioscience and Applied Research
Hepatocellular carcinoma (HCC) is the most prevalent and life-threatening form of liver cancer worldwide. In Egypt, HCC ranks as the second most common cancer in men and the sixth most common in women.
Osama Roshdy, Mai El-Daly, Mohamed Mohamed, Mohamed Abdel-Hamid, Mohamed Zanaty   +4 more
doaj   +1 more source

Accelerated cardiovascular risk after viral clearance in hepatitis C patients with the NAMPT-rs61330082 TT genotype: An 8-year prospective cohort study

Virulence, 2021
Involvement of extracellular nicotinamide phosphoribosyltransferase (eNAMPT, i.e., visfatin or pre-B-cell colony-enhancing factor), a cancer metabokine, in chronically hepatitis C virus (HCV)-infected (CHC) patients with sustained virological responses ...
Ming-Ling Chang, Yu-Sheng Lin, Ming-Yu Chang, Chia-Lin Hsu, Rong-Nan Chien, Cathy SJ Fann   +5 more
doaj   +1 more source

Boceprevir for Previously Treated Chronic HCV Genotype 1 Infection

New England Journal of Medicine, 2011
BACKGROUND In patients with chronic infection with hepatitis C virus (HCV) genotype 1 who do not have a sustained response to therapy with peginterferon–ribavirin, outcomes after retreatment are suboptimal.
B. Bacon, S. Gordon, E. Lawitz, P. Marcellin, J. Vierling, S. Zeuzem, F. Poordad, Z. Goodman, H. Sings, N. Boparai, M. Burroughs, C. Brass, J. Albrecht, R. Esteban   +13 more
semanticscholar   +1 more source